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Levobunolol Action Pathway
smpdb.ca/view/SMP0000666Drug actionLevobunolol bind to beta1-adrenergic and beta2-adrenergic receptors in heart and vascular smooth muscle to block the binding of other adrenergic neurotransmitters such as norepinephrine, which lead to
Practolol Action Pathway
smpdb.ca/view/SMP0000669Drug actionPractolol bind to beta1-adrenergic receptors in heart and vascular smooth muscle to block the binding of other adrenergic neurotransmitters such as norepinephrine, which lead to decreased blood pressure
Dobutamine Action Pathway (New)
smpdb.ca/view/SMP0123129Drug actionUnlike dopamine, dobutamine does not cause release of endogenous norepinephrine. Instead, it acts as a cardiac stimulant and stimulates adrenergic receptors to increase force of contraction.
Prazosin Action Pathway
smpdb.ca/view/SMP0125086Drug actionThis inhibition blocks the vasoconstricting (narrowing) effect of catecholamines (epinephrine and norepinephrine) on the vessels, leading to peripheral blood vessel dilation.
Caffeine Vasodilation Action Pathway
smpdb.ca/view/SMP0125283Drug actionThe antagonism of adenosine A1 receptors allows more norepinephrine to be released into the synapse where it causes contractions of the heart muscles through the norepinephrine subpathway. … Adenosine A1 receptors inhibit the release of catecholamines like norepinephrine from neurons that innervate the heart muscles.
Milnacipran SNRI - Serotonin reuptake Inhibition Action Pathway
smpdb.ca/view/SMP0126399Drug actionMilnacipran is a serotonin and norepinephrine reuptake inhibitor (SNRI). … Such NE pain mitigation is consequently also enhanced by milnacipran's ability to enhance the presence of NE by inhibiting its reuptake via norepinephrine transporters at synaptic clefts
Fluvoxamine Mechanism of Action Action Pathway New
smpdb.ca/view/SMP0126511Drug actionAs with other SSRIs, it showed weak effects on norepinephrine and dopamine neuronal reuptake.
Cocaine Dopamine-reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0126543Drug actionIt primarily acts on sensory neurons in the nasal cavity, but also inhibits dopamine, serotonin, and norepinephrine re-uptake channels.
Amitriptyline Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126617Drug actionAmitriptyline by blocking the reuptake of both serotonin and norepinephrine neurotransmitters. In serotonergic neurons, serotonin is synthesized from tryptophan and stored in synaptic vesicles. … The monoamine hypothesis in depression, one of the oldest hypotheses, postulates that deficiencies of serotonin (5-HT) and/or norepinephrine (NE) neurotransmission in the brain lead to depressive effects
Galantamine Action Pathway (new, revision)
smpdb.ca/view/SMP0126671Drug actionIt also acts as an allosteric modulator for the neuronal acetylcholine receptor, helping control the release of neurotransmitters like acetylcholine, GABA, glutamate, dopamine, serotonin and norepinephrine