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Metabolism and Physiological Effects of Indolelacetyl glutamine
smpdb.ca/view/SMP0126755MetabolicSeveral intestinal bacteria, such as Bacteroides, Clostridia, and E. coli, can catabolize Trp to tryptamine and indole pyruvic acid, which are then converted to indole-3-acetic acid, indole propionic acid … , and indole lactic acid.
Metabolism and Physiological Effects of 3-Methylhistidine
smpdb.ca/view/SMP0126757Metabolicacid. … synthesized only in the muscle by the methylation of one histidine residue in actin and in varying amounts in myosin depending on the type of muscle.
Metabolism and Physiological Effects of O-Sulfotyrosine
smpdb.ca/view/SMP0126811MetabolicO-Sulfotyrosine belongs to the class of organic compounds known as phenylalanine and derivatives. … Secreted proteins and extracellular parts of membrane proteins that pass through the Golgi apparatus may be sulfated.
Metabolism and Physiological Effects of S-Adenosylhomocysteine
smpdb.ca/view/SMP0127690MetabolicIt is toxic to immature lymphocytes and can lead to immunosuppression. … Methionine can be obtained from foods such as meat, eggs, dairy products, and nuts and is converted to adenosylmethionine which is then further converted to adenosylhomocysteine in the hepatocytes of the
Enzymes: Large neutral amino acids transporter small subunit 1Congenital Bile Acid Synthesis Defect Type II
smpdb.ca/view/SMP0000314DiseaseChenodeoxycholic acid and cholic acid are decreased in plasma and urine. … Symptoms of this disease include cholestatic jaundice, atypical oxo and allo bile acids in urine and serum, liver failure, and steatosis.
Congenital Bile Acid Synthesis Defect Type III
smpdb.ca/view/SMP0000318DiseaseThe synthesis of primary bile acids from cholesterol occurs via two pathways: the classic neutral pathway involving cholesterol 7-alpha-hydroxylase (CYP7A1), and the acidic pathway involving a distinct … CBASIII is characterized by accumulation of bile acids in the urine. Symptoms include severe cholestasis, cirrhosis, and liver failure.
Congenital Bile Acid Synthesis Defect Type II
smpdb.ca/view/SMP0125689DiseaseChenodeoxycholic acid and cholic acid are decreased in plasma and urine. … Symptoms of this disease include cholestatic jaundice, atypical oxo and allo bile acids in urine and serum, liver failure, and steatosis.
Salla Disease/Infantile Sialic Acid Storage Disease
smpdb.ca/view/SMP0125714DiseaseThere are three forms of Salla disease: infantile free sialic acid storage disease (ISSD), Salla disease, and intermediate severe Salla disease. … Salla disease, also called sialic acid storage disease, is a rare inborn error of metabolism (IEM) and autosomal recessive disorder of lysosomal storage caused by a defective SLC17A5 gene.
Enzymes: Sialic acid synthase, N-acetyl-D-glucosamine kinaseSalla Disease/Infantile Sialic Acid Storage Disease
smpdb.ca/view/SMP0000240DiseaseThere are three forms of Salla disease: infantile free sialic acid storage disease (ISSD), Salla disease, and intermediate severe Salla disease. … Salla disease, also called sialic acid storage disease, is a rare inborn error of metabolism (IEM) and autosomal recessive disorder of lysosomal storage caused by a defective SLC17A5 gene.
Enzymes: Sialic acid synthase, N-acetyl-D-glucosamine kinaseMetabolism and Physiological Effects of 3-Deoxyglucosone
smpdb.ca/view/SMP0125516MetabolicAn amino acid like arginine or lysine are combined with glucose to make a schiff base and water. The schiff base is unstable so it becomes the stable amadori product. … It normally is synthesized and accumulates with high serum glucose due to diabetes. 3-deoxyglucosone causes cell apoptosis and neurotoxicity.