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Esketamine Action Pathway
smpdb.ca/view/SMP0126267Drug actionEsketamine, known by the brand name Spravato, is a NMDA receptor antagonist used for treatment-resistant depression. It is nasal sprayand the s-enantiomer of Ketamine. It is considered a central nervous system depressant agent that can c...
Levoleucovorin Action Pathway
smpdb.ca/view/SMP0126269Drug actionLevoleucovorin is a folate analog, used to counter the adverse effects of folic acid antagonists. Commonly used in combination with chemotherapy and 5-fluorouracil to treat patients with colorectal cancer. Folic acid is necessary in orde...
Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Serine · Glutamic acid · Glycine · Folic acid +1 morePralatrexate Action Pathway
smpdb.ca/view/SMP0126296Drug actionPralatrexate is a folate analog, used for the treatment of peripheral T-cell lymphoma. Administered intravenously it acts to inhibit dihydrofolate reductase, specifically in cancer cells that have an overexpression of a transporter known...
Raltitrexed Action Pathway
smpdb.ca/view/SMP0126304Drug actionRaltitrexed is a folate analog that is used in the treatment of colorectal cancer, that is an inhibitor of thymidylate synthase. Inhibiting thymidylate synthase stops the proliferation of cancer cells, as it stops the production and form...
Amantadine NMDA Antagonist Action Pathway
smpdb.ca/view/SMP0126484Drug actionAmantadine is a medication used to treat dyskinesia in Parkinson's patients who are recieving levodopa. It is also an antiviral medicine that is used to treat influenza A. The antiarkinsonic effects are not fully understood, but it appea...
Azathioprine Action Pathway (New)
smpdb.ca/view/SMP0126488Drug actionAzathioprine is an immunosuppressor prodrug. It is used to treat rheumatoid arthritis, Crohn's disease, and ulcerative colitis. Also, azathioprine is used in the prevention of renal transplant rejection. This molecule is the prodrug of 6...
Drugs: Tetrahydrofolic acid · Ademetionine · L-Glutamine · Adenosine phosphate · Glutamic acid · Glycine +13 moreParamethadione Action Pathway
smpdb.ca/view/SMP0126675Drug actionParamethadione is an anticonvulsant in the oxazolidinedione class. It is associated with fetal trimethadione syndrome, which is also known as paramethadione syndrome. It is used for the control of absence (petit mal) seizures that are re...
Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Paramethadione · Calcium · Magnesium cation +3 moreMethylphenobarbital Action Pathway
smpdb.ca/view/SMP0126819Drug actionMephobarbital, a barbiturate, undergoes metabolism into phenobarbital and has been employed for similar purposes, particularly in managing epilepsy; however, there exists no evidence supporting its superiority over phenobarbital. It serv...
Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Methylphenobarbital · Calcium · Magnesium cation +3 morePhenobarbital Action Pathway
smpdb.ca/view/SMP0126831Drug actionPhenobarbital, a prolonged-acting barbiturate with anticonvulsant attributes, is utilized to address all forms of seizures, excluding absent seizures. Functioning as a nonselective depressant of the central nervous system, it engages inh...
Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Phenobarbital · Calcium · Magnesium cation +3 moreZopiclone Action Pathway
smpdb.ca/view/SMP0126832Drug actionZopiclone, a nonbenzodiazepine hypnotic belonging to the pyrazolopyrimidine class, is employed for the short-term management of insomnia. Operating outside the benzodiazepine and barbiturate realms, it interacts with the gamma-aminobutyr...