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3-Hydroxyisobutyric Acid Dehydrogenase Deficiency
smpdb.ca/view/SMP0125673Diseaseacid. … This enzyme converts 2-methyl-3-oxopropanoate, CoA and water into propanoyl-CoA, using NAD+ as an oxidizing agent, and producing a hydrogen ion and hydrogencarbonate as byproducts.
Enzymes: Branched-chain-amino-acid aminotransferase, cytosolic, Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrialTiaprofenic acid Predicted Metabolism Pathway
smpdb.ca/view/SMP0174732MetabolicMetabolites of Tiaprofenic acid are predicted with biotransformer.
Tolfenamic acid Predicted Metabolism Pathway
smpdb.ca/view/SMP0174765MetabolicMetabolites of Tolfenamic acid are predicted with biotransformer.
Mycophenolic Acid Metabolism Pathway (old)
smpdb.ca/view/SMP0000652Drug metabolismMycophenolic Acid (MPA) is an immunosuppressive agent that acts as a noncompetitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). … After absorption, MMF is hydrolyzed to MPA and N-(2-carboxymethyl)- morpholine, N-(2-hydroxyethyl)-morpholine, and the N-oxide of N-(2-hydroxyethyl)-morpholine by the carboxylesterases CES-1 (in the liver
Tranexamic Acid Action Pathway (New)
smpdb.ca/view/SMP0124487Drug actionTranexamic acid competitively and reversibly inhibits the activation of plasminogen via binding at several distinct sites, including four or five low-affinity sites and one high-affinity site. … Tranexamic acid is a synthetic derivative of lysine used as an antifibrinolytic in the treatment and prevention of major bleeding. It targets plasminogen in blood vessels where these clots occur.
Mefenamic Acid NSAID Action Pathway
smpdb.ca/view/SMP0124586Drug actionMefenamic acid is an NSAID used to treat mild to moderate pain for no more than a week, and primary dysmenorrhea. It has analgesic, anti-inflammatory, and antipyretic properties. … Mefenamic acid inhibits the action of COX-1 and COX-2 on the endoplasmic reticulum membrane. This reduces the formation of prostaglandin H2 and therefore, prostaglandin E2 (PGE2).
Salicylic Acid COX Action Pathway
smpdb.ca/view/SMP0124590Drug actionSalicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. … Salicylic acid inhibits the action of COX-1 and COX-2 on the endoplasmic reticulum membrane. This reduces the formation of prostaglandin H2 and therefore, prostaglandin E2 (PGE2).
Tiaprofenic Acid Action Pathway (New)
smpdb.ca/view/SMP0124607Drug actionTiaprofenic acid is a nonsteroidal anti-inflammatory (NSAID) used to manage inflammation and analgesia associated with rheumatoid arthritis and osteoarthritis. … Tiaprofenic acid possess anti-inflammatory, analgesic and antipyretic activity.
Drugs: Glutathione · Dinoprostone · Calcium · Tiaprofenic acid · Mesoheme · Prostaglandin G2 +1 moreMycophenolic acid Predicted Metabolism Pathway
smpdb.ca/view/SMP0174716MetabolicMetabolites of Mycophenolic acid are predicted with biotransformer.
Fatty Acid Elongation in Mitochondria
smpdb.ca/view/SMP0000054MetabolicTo create longer, shorter, oxidized, reduced fatty acids, palmitic acid is subjected to enzymatic reactions by reductases, hydroxylases, elongases and mixed function oxidases. … In liver and kidney fatty acid elongation operates best in the presence of both NADH and NADPH, whereas in heart and skeletal muscle, only NADH is required.