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Displaying results 141 - 150 of 2873 in total
  1. Pathway

    Minaprine Acetylcholinesterase Antidepressant Action Pathway

    smpdb.ca/view/SMP0126689
    Drug action

    Minaprine is an amino-phenylpyridazine antidepressant. It is indicated in the treatment of various depressive states. Minaprine acts on many targets in the neurons. Firstly, this drug binds as an antagonist to the serotonin type 2 recept...

    Drugs: Choline · Minaprine · Calcium · Magnesium cation · Acetylcholine · Acetic acid
    Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit beta-1
  2. Pathway

    Metrifonate Action Pathway

    smpdb.ca/view/SMP0126725
    Drug action

    Metrifonate is an acetylcholinesterase inhibitor, a prodrug that is non-enzymatically converted into its active form Dichlorvos. While binding to acetylcholinesterase it prevents the breakdown of acetylcholine, allowing the neurotransmit...

    Drugs: Choline · Calcium · Magnesium cation · Acetylcholine · Acetic acid · Metrifonate
    Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit beta-1
  3. Pathway

    Amitriptyline Serotonin Antagonist Action Pathway

    smpdb.ca/view/SMP0126617
    Drug action

    Once an action potential arrives at the nerve terminal, calcium channels open, causing the influx of calcium in the cytosol. … Calcium then triggers the release of neurotransmitters stored in synaptic vesicles via exocytosis.

    Drugs: Pyridoxal phosphate · Tryptophan · Amitriptyline · Sapropterin · Calcium · Iron +1 more
    Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1
  4. Pathway

    Pancreas Function - Alpha Cell

    smpdb.ca/view/SMP0121029
    Physiological

    This causes an increase in action potentials and opens voltage gate calcium channels causing an increase of calcium into the cell. This triggers the exocytosis of glucagon from the cell. … The membrane depolarizes to a membrane potential that inactivates voltage dependent calcium channels. This results in decreased intracellular calcium and inhibits exocytosis of glucagon.

    Drugs: ATP · Potassium cation · Calcium
    Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1
  5. Pathway

    Bromocriptine Mechanism of Action Action Pathway

    smpdb.ca/view/SMP0126674
    Drug action

    Decreases in intracellular calcium levels may also be brought about via inhibition of calcium influx through voltage-gated calcium channels, rather than via inhibition of adenylyl cyclase. … Dopamine-stimulated growth hormone release from the pituitary gland is mediated by a decrease in intracellular calcium influx through voltage-gated calcium channels rather than via adenylyl cyclase inhibition

    Drugs: Pyridoxal phosphate · Tyrosine · Dopamine · Bromocriptine · Levodopa · Calcium +2 more
    Enzymes: Voltage-dependent calcium channel subunit alpha-2/delta-1, Voltage-dependent N-type calcium channel subunit alpha-1B
  6. Pathway

    Chlorpromazine - Dopamine Antagonist Action Pathway

    smpdb.ca/view/SMP0126485
    Drug action

    Prochlorperazine and chlorpromazine are examples of this class of Phenothiazines. Phenothiazines antagonize the D2 receptor, most notably in the area postrema in the brain. IV, PO, and rectal (PR) formulations are available. Side effects...

    Drugs: Pyridoxal phosphate · Tyrosine · Sapropterin · Chlorpromazine · Dopamine · Levodopa +2 more
    Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1
  7. Pathway

    Triflupromazine Mechanism of Action Action Pathway

    smpdb.ca/view/SMP0126491
    Drug action

    Triflupromazine is a member of a class of drugs called phenothiazines, which are dopamine D1/D2 receptor antagonists. Triflupromazine is used particularly to control violent behavior during acute episodes of psychotic disorders. It can a...

    Drugs: Pyridoxal phosphate · Tyrosine · Sapropterin · Triflupromazine · Dopamine · Levodopa +2 more
    Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1
  8. Pathway

    Fluphenazine Mechanism of Action Action Pathway

    smpdb.ca/view/SMP0126501
    Drug action

    Fluphenazine is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic disorders. Fluphenazine has not been shown effective in the management of behavioural complications in patients ...

    Drugs: Pyridoxal phosphate · Tyrosine · Sapropterin · Fluphenazine · Dopamine · Levodopa +2 more
    Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1
  9. Pathway

    Lurasidone Dopamine Antagonist Action Pathway

    smpdb.ca/view/SMP0126526
    Drug action

    Lurasidone is is a benzothiazol derivative and an atypical antipsychotic used to treat schizophrenia and depressive episodes associated with bipolar I disorder. Lurasidone is an atypical antipsychotic that is a D2 and 5-HT2A (mixed serot...

    Drugs: Pyridoxal phosphate · Tyrosine · Sapropterin · Dopamine · Levodopa · Calcium +2 more
    Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1
  10. Pathway

    Triflupromazine Serotonin Antagonist Action Pathway

    smpdb.ca/view/SMP0126551
    Drug action

    Triflupromazine is a member of a class of drugs called phenothiazines, which are dopamine D1/D2 receptor antagonists. Triflupromazine is used particularly to control violent behavior during acute episodes of psychotic disorders. It can a...

    Drugs: Pyridoxal phosphate · Tryptophan · Sapropterin · Triflupromazine · Calcium · Iron +1 more
    Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1