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Bromocriptine Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126674Drug actionBromocriptine is an ergot alkaloid derivative in the dopamine D2 agonist class of drugs. Prolactin release-inhibiting hormone (PRIH) is the catecholamine neurotransmitter dopamine. Bromocriptine is an FDA-approved medication indicated fo...
Enzymes: Sodium-dependent dopamine transporterVilazodone mechanism of Action Action Pathway
smpdb.ca/view/SMP0126404Drug actionVilazodone selectively inhibits serotonin reuptake in the central nervous system as well as acting as a partial agonist of 5HT-1A receptors. The exact mechanism for how these effects translate to its antidepressant effects are not known ...
Enzymes: Sodium-dependent serotonin transporterZiprasidone Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126472Drug actionZiprasidone is an atypical antipsychotic used to treat schizophrenia, bipolar mania, and acute agitation in schizophrenic patients. It also indicated improvement on the manic syndrome subscale that measures symptoms of mania such as mood...
Enzymes: Sodium-dependent dopamine transporterThiethylperazine Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126476Drug actionThiethylperazine is in the class of the piperazine - phenothiazines which are a class of first generation antipsychotic medications. Phenothiazines are generally dopamine receptor antagonists. Thiethylperazine' s antipsychotic effect is ...
Drugs: Pyridoxal phosphate · Tyrosine · Sapropterin · Thiethylperazine · Dopamine · Levodopa +2 moreEnzymes: Sodium-dependent dopamine transporterAripiprazole Dopamine agonist Action Pathway
smpdb.ca/view/SMP0126454Drug actionAripiprazole is an atypical antipsychotic used in the treatment of a wide variety of mood and psychotic disorders, such as schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's syndrome....
Enzymes: Sodium-dependent dopamine transporterPseudoephedrine Action Pathway
smpdb.ca/view/SMP0125255Drug actionPseudoephedrine also inhibits sodium dependent noradrenaline receptors which prevents the reuptake of norepinephrine into the presynaptic neuron. … Pseudophedrine also activates on beta receptors, and it inhibits sodium dependent dopamine and serotonin transporters, however not to the same effect or degree as it affects alpha receptors and the norepinephrine
Drugs: Ascorbic acid · Norepinephrine · Pseudoephedrine · Dopamine · Calcium · Magnesium cation +1 moreEnzymes: Sodium-dependent noradrenaline transporterMethyldopa Action Pathway
smpdb.ca/view/SMP0125087Drug actionMethyldopa is a centrally-acting alpha-2 adrenergic agonist used to manage hypertension alone or in combination with hydrochlorothiazide, and to treat hypertensive crises. Alpha-adrenergic receptors are essential for the regulation of bl...
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Sapropterin · Norepinephrine · Dopamine +5 moreEnzymes: Sodium-dependent noradrenaline transporterMNGIE (Mitochondrial Neurogastrointestinal Encephalopathy)
smpdb.ca/view/SMP0125720DiseaseMyoneurogastrointestinal encephalopathy, or mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE), is a multisystem disorder caused by mutations in the gene encoding thymidine phosphorylase, which normally uses thymidine an...
Enzymes: Sodium/nucleoside cotransporter 1Duloxetine SNRI - Dopamine Norepinephrine Inhibition Action Pathway
smpdb.ca/view/SMP0126450Drug actionIt blocks both sodium dependent serotonin and sodium dependent norepinephrine transporters from removing serotonin and norepinephrine respectively from the synaptic cleft.
Enzymes: Sodium-dependent noradrenaline transporterMethylphenidate Norepinephrine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0126572Drug actionMethylphenidate binds and blocks the sodium-dependent noradrenaline transporter which prevents the synaptic norepinephrine from re-entering the presynaptic neuron.
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · ATP · Norepinephrine · Methylphenidate +7 moreEnzymes: Sodium-dependent noradrenaline transporter