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Coagulation
smpdb.ca/view/SMP0000586PhysiologicalFactors VII, IX, and X are vitamin-K-dependent proteins produced in the liver. … The TF-VIIa complex is the strongest known activator of the coagulation cascade, and converts factors IX and X to IXa and Xa, respectively.
Enzymes: Vitamin K-dependent gamma-carboxylase, Vitamin K epoxide reductase complex subunit 1Phenindione Action Pathway
smpdb.ca/view/SMP0000655Drug actionPhenindione works by thinning the blood, which is done through the antagonization of vitamin K. This antagonization is needed to create the factors that cause clotting in the liver. … It is used to treat a variety of conditions, including cerebral and pulmonary embolisms, as well as cardiomyopathy.
Enzymes: Vitamin K-dependent gamma-carboxylase, Vitamin K epoxide reductase complex subunit 1Heparin.
smpdb.ca/view/SMP0000274Drug actionActivated antithrombin III will inactive prothrombin and factor Xa (also other proteases). … Heparin (also named unfractionated heparin or Clexane) is an anticoagulant medication.
Enzymes: Vitamin K-dependent gamma-carboxylase, Vitamin K epoxide reductase complex subunit 1Folate Metabolism
smpdb.ca/view/SMP0000053MetabolicFolate, or folic acid, is a very important B-vitamin involved in cell creation and preservation, as well as the protection of DNA from mutations that can cause cancer. … Many countries around the world now fortify foods with folic acid to prevent such defects.
Hyper-IgD Syndrome
smpdb.ca/view/SMP0000509DiseaseHyperimmunoglobulinemia D syndrome, or HIDS, is a condition characterized by fevers that come and go, usually lasting 3-7 days, and other various symptoms such as rashes, vomiting, diarrhea and aphthous … These are usually noticed within the first year of a patient's life, and the highest frequency of HIDS usually occurs during childhood/adolescence.
Drugs: Cholecalciferol · ATP · Magnesium cation · Iron · Dimethylallyl Diphosphate · Formic acid +8 moreEnzymes: Lysosomal acid lipase/cholesteryl ester hydrolaseGluconeogenesis
smpdb.ca/view/SMP0000128MetabolicMany other compounds can also function as substrates for gluconeogenesis such as citric acid cycle intermediates (through conversion to oxaloacetate), amino acids other than lysine or leucine, and glycerol … Gluconeogenesis, which is essentially the reverse of glycolysis, results in the sythesis of glucose from non-carbohydrate substrates such as lactate, glycerol, and glucogenic amino acids.
Fructose-1,6-diphosphatase Deficiency
smpdb.ca/view/SMP0000562DiseaseFBP1D is characterized by hypoglycemia and acidosis after fasting, caused by the impairment of gluconeogenesis. Symptoms can also include hyperventilation. … It is estimated that FBP1D affects between 1 in 350,000 and 1 in 900,000 individuals.
Hyper-IgD Syndrome
smpdb.ca/view/SMP0125642DiseaseHyperimmunoglobulinemia D syndrome, or HIDS, is a condition characterized by fevers that come and go, usually lasting 3-7 days, and other various symptoms such as rashes, vomiting, diarrhea and aphthous … These are usually noticed within the first year of a patient's life, and the highest frequency of HIDS usually occurs during childhood/adolescence.
Drugs: Cholecalciferol · ATP · Magnesium cation · Iron · Dimethylallyl Diphosphate · Formic acid +8 moreEnzymes: Lysosomal acid lipase/cholesteryl ester hydrolaseGalactosemia
smpdb.ca/view/SMP0125710DiseaseSymptoms, which present at birth, include jaundice, enlarged liver, anemia, weight loss, and vomiting. Treatment includes galactose-free diet, antibiotics, and vitamin K. … A deficiency in this enzyme results in accumulation of D-galactose and galactitol in plasma and urine; bilirubin, chloride, and galactose-1-phosphate, and transaminases in serum.
Methadone Opioid Agonist Action Pathway
smpdb.ca/view/SMP0124670Drug actionSince it is similar to morphine and other opioids it also has similar risks with addiction, respiratory depression and constipation. … Due to it's NMDA antagonism it has improved analgesic effect and opioid tolerance.
Drugs: ATP · Methadone · Calcium · Magnesium cation · Cyclic adenosine monophosphate · gamma-Aminobutyric acid +2 moreEnzymes: Gamma-aminobutyric acid type B receptor subunit 2, Gamma-aminobutyric acid receptor subunit alpha-1