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Englumafusp alfa
go.drugbank.com/drugs/DB19341Investigationaland in Combination With Glofitamab Following a Pre-treatment Dose of Obinutuzumab in Participants With Relapsed/refractory B-cell Non-hodgkin's Lymphoma). … Englumafusp alfa is under investigation in clinical trial NCT04077723 (A Study to Evaluate the Safety, Pharmacokinetics and Preliminary Anti-tumor Activity of Englumafusp Alfa in Combination With Obinutuzumab
Synonyms: humanized immunoglobulin G1-kappa anti-(human B-lymphocyte antigen CD19) modified heterodimer where the heavy and light chain variable regions of one arm have been substituted by three subunits of humanBazlitoran
go.drugbank.com/drugs/DB14990InvestigationalBazlitoran is under investigation in clinical trial NCT02092909 (Phase 1/2 Dose Escalation Study in Patients With Relapsed or Refractory Waldenstrom's Macroglobulinemia).
Synonyms: Antagonist of the endosomal Toll-like receptors (TLRs) 7, 8, and 9Categories: Nucleic Acids, Nucleotides, and NucleosidesFazpilodemab
go.drugbank.com/drugs/DB18924InvestigationalFazpilodemab is under investigation in clinical trial NCT04171765 (A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of BFKB8488A Compared With Placebo in Participants With Non-alcoholic Steatohepatitis
Synonyms: immunoglobulin G1-kappa, anti-[Homo sapiens KLB (klotho beta, b-Klotho)] and anti-[Homo sapiens FGFR1 (fibroblast growth factor receptor 1, FLT2, KAL2)], monoclonal antibody, bispecific; gamma1 heavy chain, 410-valine], anti-(human β-Klotho protein) (human monoclonal HKLB4206 γ1-chain), disulfide with monoclonal HKLB4206 κ-chain, (229→225'),(232→228')-bis(disulfide) with immunoglobulin G1 [365-tryptophan] antEtevritamab
go.drugbank.com/drugs/DB17211InvestigationalSynonyms: IMMUNOGLOBULIN SCFV-SCFV, ANTI-(HOMO SAPIENS EGFR (EPIDERMAL GROWTH FACTOR RECEPTOR, RECEPTOR TYROSINE-PROTEIN KINASE ERBB-1, ERBB1, HER1, HER-1, ERBB) VARIANT III (EGFRVIII)) AND ANTI-(HOMO SAPIENS CD3EAcazicolcept
go.drugbank.com/drugs/DB18410InvestigationalSynonyms: Fc fusion protein of a human inducible T cell costimulator ligand variant immunoglobulin domain designed to inhibit simultaneously the CD28 and ICOS inflammation pathwaysCategories: Amino Acids, Peptides, and ProteinsPetrolatum
go.drugbank.com/drugs/DB11058ApprovedInvestigationalIt is used as an ointment base, topical protectant, and lubricant.
Mixtures: A and D Diaper Rash and Skin Protectant, A and D First AidCategories: Basic Ointments and ProtectantsDoxylamine
go.drugbank.com/drugs/DB00366ApprovedInvestigationalVet approvedIt is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism.
Mixtures: Up and Up Cold and Flu Relief, Daytime Cold and Flu and Nighttime Cold and FluProducts: Berkley and Jensen Sleep Aid, Up and Up Nighttime Sleep AidGlutaminolysis and Cancer
smpdb.ca/view/SMP0002298DiseaseThe transportation of glutamine in and out regulates mTOR activation to coordinate cell growth and proliferation. … Once it reaches malic acid, it is transported outside the mitochondria and transformed into pyruvic acid and lactate.
Drugs: Pyridoxal phosphate · Pyruvic acid · Biotin · Aspartic acid · L-Glutamine · Succinic acid +9 moreNicotinate and Nicotinamide Metabolism
smpdb.ca/view/SMP0000048MetabolicNicotinate (niacin) and nicotinamide - more commonly known as vitamin B3 - are precursors of the coenzymes nicotinamide-adenine dinucleotide (NAD+) and nicotinamide-adenine dinucleotide phosphate (NADP … The precursors are fed into the NAD+ biosynthetic pathwaythrough adenylation and phosphoribosylation reactions.
Fructose and Mannose Degradation
smpdb.ca/view/SMP0000064MetabolicFructose causes less of an insulin response compared to glucose and thus may be a preferred sugar for diabetics. … Fructose and mannose are monosaccharides that can be found in many foods. Fructose can join with glucose to form sucrose. Mannose can be converted to glucose. Both may be used as food sweeteners.