Search
Ziprasidone Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126472Drug actionIt also indicated improvement on the manic syndrome subscale that measures symptoms of mania such as mood, insomnia, excessive energy and activity, and overall behavior and ideation. … The antagonization of both histaminergic and adrenergic (a1) receptors can induce somnolence and orthostatic hypotension.
Enzymes: Aromatic-L-amino-acid decarboxylase, D(2) dopamine receptorMethotrexate Action Pathway (new)
smpdb.ca/view/SMP0126242Drug actionMethotrexate is a chemotherapeutic drug and is a folic acid derivative that inhibits many enzymes involved in nucleotide synthesis. … Some overdose symptoms that can occur include nausea, vomiting, gastrointestinal issues and or complications with red blood cells, white blood cells and or platelets.
Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease
smpdb.ca/view/SMP0000374DiseaseA defect in this enzyme results in accumulation of glycogen in affected tissues, like liver and kidney; decreased glucose level; and accumulation of lactate. … Glucose-6-phosphatase hydrolyzes glucose-6-phosphate to glucose and is responsible for the regulation of blood glucose level.
Triosephosphate Isomerase Deficiency
smpdb.ca/view/SMP0125793DiseaseThis disorder causes anemia, movement problems and muscle weakness. … As a result of the lack of red blood cells to carry oxygen through the body, patients may experience fatigue and shortness of breath.
Steroid Biosynthesis
smpdb.ca/view/SMP0000023Metabolicvitamin D. … Cholesterol is an essential constituent of lipid bilayer membranes (where it forms cholesterol esters) and is the starting point for the biosynthesis of steroid hormones, bile acids and bile salts, and
Drugs: Cholecalciferol · ATP · Magnesium cation · Iron · Dimethylallyl Diphosphate · Formic acid +8 moreEnzymes: Lysosomal acid lipase/cholesteryl ester hydrolaseThiethylperazine Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126476Drug actionIt is a sedating antihistamine used as an antiemetic agent for the control of nausea and vomiting associated with surgical procedures. … Thiethylperazine' s antipsychotic effect is due to antagonism at dopamine and serotonin type 2 receptors, with greater activity at serotonin 5-HT2 receptors than at dopamine type-2 receptors.
Drugs: Pyridoxal phosphate · Tyrosine · Sapropterin · Thiethylperazine · Dopamine · Levodopa +2 moreEnzymes: Aromatic-L-amino-acid decarboxylase, D(2) dopamine receptorTriosephosphate Isomerase Deficiency
smpdb.ca/view/SMP0000563DiseaseThis disorder causes anemia, movement problems and muscle weakness. … As a result of the lack of red blood cells to carry oxygen through the body, patients may experience fatigue and shortness of breath.
Glycogenosis, Type IB
smpdb.ca/view/SMP0000573DiseaseSymptoms of the disorder include longer sleeping time through night, tiredness and seizures due to low blood sugar. Treatment with diet management is very effective. … Glycogenosis, Type IB, also called von Gierke disease or GSDI, is a rare inborn error of metabolism (IEM) and autosomal recessive disorder which caused by a defective glucose-6-phosphate translocase.
Glycogenosis, Type IC
smpdb.ca/view/SMP0000574DiseaseGlycogenosis, Type IC, a sub-category of glycogen storage disease type I, is a rare inborn error of metabolism (IEM) and caused by a defective glucose-6-phosphatase translocase. … Symptoms of the disorder include longer sleeping time through night, tiredness and seizures due to low blood sugar. Treatment with diet management is very effective.
Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease
smpdb.ca/view/SMP0125790DiseaseA defect in this enzyme results in accumulation of glycogen in affected tissues, like liver and kidney; decreased glucose level; and accumulation of lactate. … Glucose-6-phosphatase hydrolyzes glucose-6-phosphate to glucose and is responsible for the regulation of blood glucose level.