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Dopamine beta-Hydroxylase Deficiency
smpdb.ca/view/SMP0000498DiseaseNoradrenaline and adrenaline are generally not detectable in plasma, urine, and cerebrospinal fluid, but dopamine is increased 7- to 12-fold in plasma, 4-fold in urine, and 20-fold in CSF. … Treatment with dihydroxyphenylserine has been shown to reduce symptoms and signs of postural hypotension and increase plasma levels of noradrenaline.
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 moreSalicylic Acid Action Pathway
smpdb.ca/view/SMP0000709Drug actionProstaglandin G/H synthase 1 and 2 catalyze the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 to prostaglandin H2 in the metabolism pathway. … Salicylic acid can block prostaglandin synthesis by the action of inhibition of prostaglandin G/H synthase 1 and 2.
Drugs: Glutamic acid · Glutathione · Dinoprostone · Salicylic acid · Calcium · Magnesium cation +5 moreDopamine Action Pathway
smpdb.ca/view/SMP0125137Drug actionLow doses of dopamine cause vasodilation while can help with renal failure and related conditions. … Dopamine is a neurotransmitter that can be taken as a tablet for hemodynamic imbalances caused by many heart problems and diseases.
Amitriptyline Norepinephrine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0125187Drug actionThe norepinephrine is released into the synapse and acts on α1, β1 and β2receptors which contribute to mood improvements. … Amitriptyline by blocking the reuptake of both serotonin and norepinephrine neurotransmitters. In adrenergic neurons, norepinephrine is synthesized from tyrosine and stored in synaptic vesicles.
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Amitriptyline · Sapropterin · Norepinephrine +5 moreMethamphetamine Dopamine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0125231Drug actionMethamphetamine (metamfetamine) is a psychostimulant and sympathomimetic drug. It is mainly taken recreationally but can be taken for ADHD and exogenous obesity in the form of a drug called Desoxyn. … Methamphetamine induces effects of euphoria and affects heart rate, body temperature, blood pressure, appetite, attention, mood, and responses associated with alertness or alarm conditions.
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Tyrosine · Tryptophan · Sapropterin +9 moreBupropion Action Pathway
smpdb.ca/view/SMP0125268Drug actionThis helps regulate mood and behaviour in the brain as well as activating the reward system. Norepinephrine's effects on MDD is less studied and less understood than dopamine. … Norepinephrine activates Alpha-1A adrenergic receptors in the brain, which are desensitized in the brains of depressed patients and implicated in the limbic system for regulating behaviour and mood.
Tyrosinemia, Transient, of the Newborn
smpdb.ca/view/SMP0125592Diseaseand derivatives. … The inhibition is reversible by removal of excess substrate and by reducing agents such as ascorbic acid, 2, 6-dichiorophenolindophenol, and a number of hydroquinone and phenylenediamine compounds.
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 moreDopamine beta-Hydroxylase Deficiency
smpdb.ca/view/SMP0125594DiseaseNoradrenaline and adrenaline are generally not detectable in plasma, urine, and cerebrospinal fluid, but dopamine is increased 7- to 12-fold in plasma, 4-fold in urine, and 20-fold in CSF. … Treatment with dihydroxyphenylserine has been shown to reduce symptoms and signs of postural hypotension and increase plasma levels of noradrenaline.
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 moreDroxidopa B1-Adrenergic Cardiac Muscle Contraction Action Pathway
smpdb.ca/view/SMP0126078Drug actionassociated symptoms of lightheadedness, dizziness, blurred vision, and syncope through the induction of tachycardia (increased heart rate) and hypertension. … Some side effects of using droxidopa may include headache, dizziness, nausea, high blood pressure, and fainting.
Imipramine Action Pathway (New)
smpdb.ca/view/SMP0126359Drug action, and hallucinations. … schizophrenia, for the treatment of acute stress disorder and posttraumatic stress disorder, and for symptomatic treatment of postherpetic neuralgia and painful diabetic neuropathy.
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Tryptophan · Sapropterin · Norepinephrine +7 more