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Displaying results 181 - 190 of 359 in total
  1. Drug

    Practolol

    go.drugbank.com/drugs/DB01297
    Approved

    A beta-adrenergic antagonist that has been used in the emergency treatment of cardiac arrhythmias.

  2. Drug

    Methadone

    go.drugbank.com/drugs/DB00333
    ApprovedInvestigational

    gold standard reference opioid, methadone also acts as an agonist of κ- and σ-opioid receptors, as an antagonist of the N-methyl-D-aspartate (NMDA) receptor, and as an inhibitor of serotonin and norepinephrine

  3. Pathway

    Nicotine Action Pathway

    smpdb.ca/view/SMP0000431
    Drug action

    Nicotine is a stimulant drug that acts as an agonist at nicotinic acetylcholine receptors. These are ionotropic receptors composed of five homomeric or heteromeric subunits. In the brain, nicotine binds to nicotinic acetylcholine recepto...

    Drugs: NADH · ATP · Nicotine · Norepinephrine · Dopamine · Potassium cation +5 more
  4. Drug

    Nicergoline

    go.drugbank.com/drugs/DB00699
    Approved

    An ergot derivative that has been used as a cerebral vasodilator and in peripheral vascular disease. It has been suggested to ameliorate cognitive deficits in cerebrovascular disease.

  5. Pathway

    Regulation of Lipolysis

    smpdb.ca/view/SMP0573273
    Signaling

    By contrast, during fasting or cold exposure sympathetic nerves release norepinephrine, which binds β‑adrenergic receptors on adipocytes to activate Gs proteins and adenylyl cyclase, raising cAMP levels

    Drugs: Adenosine phosphate · ATP · Norepinephrine · Adenosine · Epinephrine · Dinoprostone +6 more
  6. Pathway

    Clomipramine Action Pathway (New)

    smpdb.ca/view/SMP0126354
    Drug action

    It blocks both sodium-dependent serotonin and sodium-dependent norepinephrine transporters from removing serotonin and norepinephrine respectively from the synaptic clefts in the brain.

    Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Tryptophan · NADH · Sapropterin +10 more
  7. Drug

    DL-Methylephedrine

    go.drugbank.com/drugs/DB11278
    Approved

    Methylephedrine is a sympathomimetic amine that appears in various over-the-counter cough and cold medications throughout the world , , . The abuse of methylephedrine-containing medications has been reported in Japan. Methylephedrine is ...

  8. Pathway

    Phentermine Action Pathway

    smpdb.ca/view/SMP0125178
    Drug action

    In these synaptic vesicles, phentermine displaces the norepinephrine stored, and stimulates VMAT2 to spew out the stored norepinephrine into the cytosol. … The norepinephrine in the synapse activates beta-2 and alpha-1 adrenergic receptors on post-synaptic neurons.

    Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Tyrosine · NADH · Phentermine +8 more
  9. Pathway

    Pargyline Action Pathway

    smpdb.ca/view/SMP0126708
    Drug action

    The first one is found in cells located in the periphery and breakdown serotonin, norepinephrine, epinephrine, dopamine, and tyramine. … The second one, the B isoform, breakdowns phenylethylamine, norepinephrine, epinephrine, dopamine, and tyramine. This isoform is found in the extracellular tissues and mainly in the brain.

    Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Tyrosine · NADH · Sapropterin +8 more
  10. Drug

    Bretylium

    go.drugbank.com/drugs/DB01158
    Approved

    Bretylium blocks the release of noradrenaline from the peripheral sympathetic nervous system, and is used in emergency medicine, cardiology, and other specialties for the acute management of ventricular tachycardia and ventricular fibril...