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Displaying results 11 - 20 of 2757 in total
  1. Target

    Vitamin K-dependent protein C

    go.drugbank.com/bio_entities/BE0000380
    TargetEnzymeHumans

    Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (PubMed:25618265, PubMed:39880037

    Polypeptides: Vitamin K-dependent protein CSynonyms: Anticoagulant protein C
  2. Target

    Protein kinase C iota type

    go.drugbank.com/bio_entities/BE0003889
    TargetHumans

    Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. … In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step.

    Polypeptides: Protein kinase C iota typeSynonyms: Atypical protein kinase C-lambda/iota
  3. Target

    Protein kinase C delta type

    go.drugbank.com/bio_entities/BE0002417
    TargetHumans

    Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein … The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (By similarity).

    Polypeptides: Protein kinase C delta typeSynonyms: Tyrosine-protein kinase PRKCD
  4. Target

    Protein kinase C zeta type

    go.drugbank.com/bio_entities/BE0009589
    TargetHumans

    Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved … Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231)

    Polypeptides: Protein kinase C zeta type
  5. Target

    Protein kinase C gamma type

    go.drugbank.com/bio_entities/BE0009588
    TargetHumans

    Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). … Acts as a regulator of dopamine signaling by mediating constitutive phosphorylation of dopamine receptor DRD1, inhibiting G protein-coupled receptor signaling (PubMed:20969574)

    Polypeptides: Protein kinase C gamma type
  6. Target

    Protein kinase C theta type

    go.drugbank.com/bio_entities/BE0001385
    TargetHumans

    Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231) … Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation

    Polypeptides: Protein kinase C theta type
  7. Target

    Protein kinase C beta type

    go.drugbank.com/bio_entities/BE0000872
    TargetHumans

    Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231). … Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative

    Polypeptides: Protein kinase C beta type
  8. Target

    Protein kinase C alpha type

    go.drugbank.com/bio_entities/BE0001132
    TargetHumans

    synthesis, protein-DNA ratio and cell surface area. … Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (PubMed:36040231).

    Polypeptides: Protein kinase C alpha type
  9. Target

    Myosin-binding protein C, cardiac-type

    go.drugbank.com/bio_entities/BE0014590
    TargetHumans

    Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands.

    Polypeptides: Myosin-binding protein C, cardiac-typeSynonyms: C-protein, cardiac muscle isoform, Cardiac MyBP-C
  10. Target

    Ubiquitin-conjugating enzyme E2 C

    go.drugbank.com/bio_entities/BE0010756
    TargetHumans

    Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. … Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit

    Polypeptides: Ubiquitin-conjugating enzyme E2 CSynonyms: Ubiquitin-protein ligase C, Ubiquitin carrier protein C