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Displaying results 11 - 20 of 2625 in total
  1. Pathway

    Epinastine H1-Antihistamine Action

    smpdb.ca/view/SMP0061191
    Drug action

    Reducing the activity of the NF-κB immune response transcription factor through the phospholipase C and the phosphatidylinositol (PIP2) signalling pathways also decreases antigen presentation and the expression

    Drugs: Epinastine · Calcium
    Enzymes: Protein kinase C beta type, Guanine nucleotide-binding protein G(q) subunit alpha
  2. Pathway

    Mirtazapine H1-Antihistamine Action

    smpdb.ca/view/SMP0062885
    Drug action

    Reducing the activity of the NF-κB immune response transcription factor through the phospholipase C and the phosphatidylinositol (PIP2) signalling pathways also decreases antigen presentation and the expression

    Drugs: Mirtazapine · Calcium
    Enzymes: Protein kinase C beta type, Guanine nucleotide-binding protein G(q) subunit alpha
  3. Pathway

    Mitochondrial Electron Transport Chain

    smpdb.ca/view/SMP0000355
    Metabolic

    Phosphate is able to enter the mitochondrial matrix via the glucose-6-phosphate translocase, and ADP is able to enter the matrix as ATP leaves it via the ADP/ATP translocase 1 protein. … However, the inner membrane is only permeable to water, oxygen and carbon dioxide, and all other molecules, including protons, require transport proteins.

    Drugs: Succinic acid · NADH · ATP · D-glyceraldehyde 3-phosphate · sn-glycerol 3-phosphate · Mesoheme +3 more
    Enzymes: Cytochrome c1, heme protein, mitochondrial, ATP synthase lipid-binding protein, mitochondrial
  4. Pathway

    Pseudoephedrine Action Pathway

    smpdb.ca/view/SMP0125255
    Drug action

    These receptors then activate the Gq protein cascade. This activates Phospolipase C which catalyzes Phosphatidylinositol 4,5-bisphosphate into Inositol 1,4,5-trisphosphate and Diacylglycerol. … Diacylglycerol activates protain kinase C which activates the voltage-dependent calcium channel, allowing calcium to enter the cell.

    Drugs: Ascorbic acid · Norepinephrine · Pseudoephedrine · Dopamine · Calcium · Magnesium cation +1 more
    Enzymes: Protein kinase C alpha type, Guanine nucleotide-binding protein G(q) subunit alpha
  5. Pathway

    Esmirtazapine H1 Antihistamine Smooth Muscle Relaxation Action Pathway

    smpdb.ca/view/SMP0174952
    Drug action

    This normally activates the Gq signalling cascade which activates phospholipase C which catalyzes the production of Inositol 1,4,5-trisphosphate (IP3) and Diacylglycerol (DAG).

    Drugs: Calcium · Magnesium cation · Esmirtazapine
    Enzymes: Protein kinase C alpha type, Guanine nucleotide-binding protein G(q) subunit alpha
  6. Pathway

    Mianserin H1 Antihistamine Smooth Muscle Relaxation Action Pathway

    smpdb.ca/view/SMP0174951
    Drug action

    This normally activates the Gq signalling cascade which activates phospholipase C which catalyzes the production of Inositol 1,4,5-trisphosphate (IP3) and Diacylglycerol (DAG).

    Drugs: Calcium · Magnesium cation · Mianserin
    Enzymes: Protein kinase C alpha type, Guanine nucleotide-binding protein G(q) subunit alpha
  7. Pathway

    Mirtazapine H1 Antihistamine Smooth Muscle Relaxation Action Pathway

    smpdb.ca/view/SMP0174888
    Drug action

    This normally activates the Gq signalling cascade which activates phospholipase C which catalyzes the production of Inositol 1,4,5-trisphosphate (IP3) and Diacylglycerol (DAG).

    Drugs: Mirtazapine · Calcium · Magnesium cation
    Enzymes: Protein kinase C alpha type, Guanine nucleotide-binding protein G(q) subunit alpha
  8. Pathway

    Dexbrompheniramine H1-Antihistamine Immune Response Action Pathway

    smpdb.ca/view/SMP0175073
    Drug action

    Reducing the activity of the NF-κB immune response transcription factor through the phospholipase C and the phosphatidylinositol (PIP2) signalling pathways also decreases antigen presentation and the expression

    Drugs: Dexbrompheniramine · Calcium
    Enzymes: Protein kinase C beta type, Protein kinase C alpha type
  9. Pathway

    Epinastine H1 Antihistamine Smooth Muscle Relaxation Action Pathway

    smpdb.ca/view/SMP0174947
    Drug action

    This normally activates the Gq signalling cascade which activates phospholipase C which catalyzes the production of Inositol 1,4,5-trisphosphate (IP3) and Diacylglycerol (DAG).

    Drugs: Epinastine · Calcium · Magnesium cation
    Enzymes: Protein kinase C alpha type, Guanine nucleotide-binding protein G(q) subunit alpha
  10. Pathway

    Histamine H1 Receptor Activation

    smpdb.ca/view/SMP0063452
    Signaling

    Upon binding by histamine, the H1 receptor allosterically activates the G-protein by exchanging GDP for GTP at the G-protein's alpha subunit (Gαq). … Both calcium and DAG activate the kinase activity of protein kinase C beta (PKC). Among many other functions, PKC activates NF-κB.

    Drugs: Calcium
    Enzymes: Protein kinase C beta type, Guanine nucleotide-binding protein G(q) subunit alpha