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Displaying results 191 - 200 of 2175 in total
  1. Pathway

    Eumelanin Biosynthesis

    smpdb.ca/view/SMP0121124
    Metabolic

    Melanin is the term used for multiple pigments found in many organisms, and specifically our skin, hair and iris tissues. There are three types of melanin, eumelanin, pheomelanin and neuromelanin. … Eumelanin is the most common, and can be brown or black.

    Drugs: Zinc
  2. Pathway

    Galactosemia III

    smpdb.ca/view/SMP0000496
    Disease

    Galactosemia III also called GALE deficiency or UDP-Galactose-4-Epimerase deficiency, is a rare inborn error of metabolism (IEM) and autosomal recessive disorder caused by either a homozygous or compound … Symptoms are similar to classic galactosemia, including jaundice, vomiting, hypotonia, failure to thrive, hepatomegaly, moderate generalized amino aciduria and marked galactosuria.

    Drugs: NADH · ATP · Magnesium cation · Iron · Zinc · Uridine diphosphate glucose +2 more
  3. Pathway

    Galactosemia III

    smpdb.ca/view/SMP0125607
    Disease

    Galactosemia III also called GALE deficiency or UDP-Galactose-4-Epimerase deficiency, is a rare inborn error of metabolism (IEM) and autosomal recessive disorder caused by either a homozygous or compound … Symptoms are similar to classic galactosemia, including jaundice, vomiting, hypotonia, failure to thrive, hepatomegaly, moderate generalized amino aciduria and marked galactosuria.

    Drugs: NADH · ATP · Magnesium cation · Iron · Zinc · Uridine diphosphate glucose +2 more
  4. Pathway

    Dalfampridine Action Pathway

    smpdb.ca/view/SMP0126397
    Drug action

    Dalfampridine, also known as Ampyra (USA) and Fampyra (Canada and Australia), is a potassium channel blocker. … Dalfampridine is a board-spectrum lipophilic potassium channel blocker and binds favorably to the open state of the potassium channel in the CNS and in the neuromuscular junctions.

    Drugs: Choline · ATP · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate +3 more
    Enzymes: Voltage-dependent L-type calcium channel subunit beta-1, Voltage-dependent calcium channel subunit alpha-2/delta-1
  5. Pathway

    Methyldopa Action Pathway

    smpdb.ca/view/SMP0125087
    Drug action

    Calcium binds to calmodulin and activates myosin light chain kinase. Myosin light chain kinase is responsicle for phosphorylating myosin light chain. … Two types of alpha receptors, alpha 1 and alpha 2, both play a role in regulating blood pressure.

    Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Sapropterin · Norepinephrine · Dopamine +5 more
    Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1
  6. Pathway

    Kidney Function- Proximal Convoluted Tubule

    smpdb.ca/view/SMP0121001
    Physiological

    The proximal convoluted tubule is part of the nephron between the Bowman's capsule and the loop of Henle. The proximal convoluted tubule functions to reabsorb sodium, water, and other ions. … All the cation and anion transport creates a gradient favourable for ion and water reabsorption, leading to an increase in blood pressure.

    Drugs: Cysteine · Potassium cation · Zinc · Urea
    Enzymes: Neutral and basic amino acid transport protein rBAT, Sodium- and chloride-dependent transporter XTRP3
  7. Pathway

    Vitamin B6 Metabolism

    smpdb.ca/view/SMP0000017
    Metabolic

    Others include,include pyridoxal, pyridoxamine, and pyridoxine. … PLP serves as cofactor in a variety of reactions including from amino acid metabolism, (in particular in reactions such as transamination, deamination, and decarboxylation).

    Drugs: Pyridoxal phosphate · Pyridoxal · Pyridoxine · Magnesium cation · Zinc · Pyridoxamine-5'-Phosphate +3 more
  8. Pathway

    Hypophosphatasia

    smpdb.ca/view/SMP0000503
    Disease

    Infantile hypophosphatasia, also called I-HPP, is a severe, rare and fatal metabolic bone disease and an inborn error of metabolism. … Early symptoms of the disorder include poor feeding, irritability, hypotonia (state of low muscle tone), failure to thrive and seizures..

    Drugs: Pyridoxal phosphate · Pyridoxal · Pyridoxine · Magnesium cation · Zinc · Pyridoxamine-5'-Phosphate +3 more
  9. Pathway

    Dopamine Action Pathway

    smpdb.ca/view/SMP0125137
    Drug action

    Protein kinase activates calcium channels in the membrane, causing the channels to open and allow Ca2+ into the cell. … Dopamine is a neurotransmitter that can be taken as a tablet for hemodynamic imbalances caused by many heart problems and diseases.

    Drugs: Ascorbic acid · ATP · Norepinephrine · Dopamine · Calcium · Pyrroloquinoline Quinone
    Enzymes: Sodium/calcium exchanger 1, Voltage-dependent P/Q-type calcium channel subunit alpha-1A
  10. Pathway

    Dopamine Action Pathway

    smpdb.ca/view/SMP0127069
    Physiological

    Protein kinase activates calcium channels in the membrane, causing the channels to open and allow Ca2+ into the cell. … Dopamine is a neurotransmitter that can be taken as a tablet for hemodynamic imbalances caused by many heart problems and diseases.

    Drugs: Ascorbic acid · ATP · Norepinephrine · Dopamine · Calcium · Pyrroloquinoline Quinone
    Enzymes: Sodium/calcium exchanger 1, Voltage-dependent P/Q-type calcium channel subunit alpha-1A