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Tezepelumab
go.drugbank.com/drugs/DB15090ApprovedInvestigationalAsthma is a heterogeneous chronic obstructive respiratory disease with both "type 2" (T2) and T2-low endotypes characterized by reduced airflow, chronic inflammation, and airway remodelling. … It was granted FDA approval on December 17, 2021, and is currently marketed under the trademark TEZSPIRE by Amgen/AstraZeneca.
Categories: Amino Acids, Peptides, and ProteinsLiothyronine
go.drugbank.com/drugs/DB00279ApprovedInvestigationalVet approved[T457] The exogenous liothyronine product was developed by King Pharmaceuticals and FDA approved in 1956.[L5578] … Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine with bound iodine.
Mixtures: Levothyroxine and Liothyronine Thyroid, Levothyroxine and Liothyronine ThyroidCategories: Sex Hormones and Insulins, combinations of levothyroxine and liothyronineNeoplasms
go.drugbank.com/conditions/DBCOND0027948Synonyms: Neoplasms benign, malignant and unspecified (incl cysts and polyps)Cerivastatin
go.drugbank.com/drugs/DB00439ApprovedWithdrawnFood and Drug Administration (FDA) announced that Bayer Pharmaceutical Division voluntarily withdrew Baycol from the U.S. market, due to reports of fatal rhabdomyolysis, a severe adverse reaction from … It has also been withdrawn from the Canadian market.[A669,L43942]
Sulfasalazine
go.drugbank.com/drugs/DB00795ApprovedInvestigational[A255582] Sulfasalazine fell out of favor as the drug of choice for RA due to poorly designed clinical trials in 1950 but regained interest from the clinical community in the late 1970. … Sulfasalazine is an anti-inflammatory drug structurally related to salicylates and other non-steroidal anti-inflammatory drugs.
Categories: Alimentary Tract and MetabolismAlpha-2-macroglobulin
go.drugbank.com/bio_entities/BE0000910TargetCarrierHumansFollowing cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase
Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1
go.drugbank.com/bio_entities/BE0000931TargetHumansHas ADP-ribosyltransferase activity toward GLP1R
Synonyms: ADP-ribosyltransferase C2 and C3 toxin-like 1Lanadelumab
go.drugbank.com/drugs/DB14597ApprovedInvestigational[A38676] Lanadelumab was approved for use in patients with hereditary angioedema by the FDA in August 2018,[L4537] followed by Health Canada in October 2018[L49226] and the EMA in November 2018. … [L4538] It is a fully human immunoglobulin, k-light-chain made in recombinant Chinese Hamster Ovary cells.
Categories: Blood and Blood Forming Organs, Amino Acids, Peptides, and ProteinsRespiratory Infection
go.drugbank.com/conditions/DBCOND0034122Synonyms: Recurrent Upper and Lower Respiratory Tract Infections (RTIs)Belinostat
go.drugbank.com/drugs/DB05015ApprovedInvestigationalIt was developed as an orphan drug to target hematological malignancies and solid tumors by TopoTarget. … It was US-approved in July 2014 as a therapeutic agent for relapsed or refractory peripheral T-cell lymphoma.
Categories: Antineoplastic and Immunomodulating Agents