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Hydrocortisone Action Pathway
smpdb.ca/view/SMP0126250Drug actionHydrocortisone, also known as Cortisol, is a glucocorticoid used to treat corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders. It is naturally secreted by the adrenal cortex. Hydrocortison...
Triamcinolone Action Pathway
smpdb.ca/view/SMP0126251Drug actionTriamcinolone is a glucocorticoid used to treat a wide variety of inflammatory conditions. As this drug is a glucocorticoid, its mechanism of action is that of the glucocorticoid response element (GRE) influencing COX-2/prostaglandin G/H...
Hyaluronic acid Drug Metabolism
smpdb.ca/view/SMP0130655MetabolicHyaluronic acid is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Hyaluronic acid passes through the liver and is then excreted from the body mainly through the kidney.
Drugs: Hyaluronic acidVitamin A Deficiency
smpdb.ca/view/SMP0000336DiseaseVitamin A deficiency can be caused by many causes. A defect in the BCMO1 gene which codes for beta,beta-carotene 15,15’-monooxygenase is one of them. Beta,beta-carotene 15,15’-monooxygenase catalyzes the chemical reaction where the two s...
Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency
smpdb.ca/view/SMP0000372DiseaseAdrenal hyperplasia type 5 (AH5) also known as Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency is a rare inborn error of metabolism (IEM) and autosomal recessive disorder of cortisol and sex steroids synthesis cause...
Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency
smpdb.ca/view/SMP0000373DiseaseAdrenal hyperplasia type 3, also called Congenital adrenal hyperplasia due to 21-hydroxylase deficiency, is caused by a defect in the CYP21A2 gene which codes for Steroid 21-hydroxylase (21-hydroxylase). Steroid 21-hydroxylase catalyzes ...
Tyrosinemia, Transient, of the Newborn
smpdb.ca/view/SMP0000494DiseaseThe inhibition is reversible by removal of excess substrate and by reducing agents such as ascorbic acid, 2, 6-dichiorophenolindophenol, and a number of hydroquinone and phenylenediamine compounds.
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 more11-beta-Hydroxylase Deficiency (CYP11B1)
smpdb.ca/view/SMP0000575Disease11-beta-Hydroxylase Deficiency, also called congenital adrenal hyperplasia (CAH), is an autosomal recessive disorder and caused by a defective 11-beta-hydroxylase. 11-beta-hydroxylase catalyzes the conversion of cortexolone into cortisol...
21-Hydroxylase Deficiency (CYP21)
smpdb.ca/view/SMP0000576DiseaseCongenital adrenal hyperplasia (CAH) refers to any of several autosomal recessive diseases resulting from mutations of genes for enzymes mediating the steps of biosynthesis of cortisol from cholesterol in the adrenal glands, also known a...
Corticosterone Methyl Oxidase II Deficiency (CMO II)
smpdb.ca/view/SMP0000578DiseaseCorticosterone methyloxidase type II (CMO-II) deficiency, also called 18-oxidase defiency or aldosterone deficiency II among other names, is a genetic disorder that is autosomally linked. It is caused by a mutation in the cytochrome P450...