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Tryptophan Metabolism
smpdb.ca/view/SMP0000063MetabolicThis pathway depicts the metabolic reactions and pathways associated with tryptophan metabolism in animals. Tryptophan is an essential amino acid. This means that it cannot be synthesized by humans and other mammals and therefore must be...
Drugs: Pyridoxal phosphate · Ademetionine · Adenosine phosphate · Glutamic acid · Tryptophan · NADH +18 moreFructose and Mannose Degradation
smpdb.ca/view/SMP0000064MetabolicFructose and mannose are monosaccharides that can be found in many foods. Fructose can join with glucose to form sucrose. Mannose can be converted to glucose. Both may be used as food sweeteners. Fructose is well absorbed, especially in ...
Aspartate Metabolism
smpdb.ca/view/SMP0000067MetabolicAspartate is synthesized by transamination of oxaloacetate by aspartate aminotransferase or amino acid oxidase. Aspartyl-tRNA synthetase can then couple aspartate to aspartyl tRNA for protein synthesis. The aspartate content in human pro...
Drugs: Pyridoxal phosphate · Arginine · Aspartic acid · L-Glutamine · Adenosine phosphate · Glutamic acid +13 moreAndrogen and Estrogen Metabolism
smpdb.ca/view/SMP0000068MetabolicThis pathway describes the inactivation and catabolism of male (androgen) and female (estrogen) hormones. Many steroid hormones are transformed by sulfatases, dehydrogenases and glucuronide transferases to enhance their solubility and to...
Retinol Metabolism
smpdb.ca/view/SMP0000074MetabolicRetinol is part of the vitamin A family, and is known as vitamin A1, and in a dietary context it is a type of preformed vitamin A. As with other preformed vitamin A's, it can be obtained from animal sources, with the highest concentratio...
Piroxicam Action Pathway
smpdb.ca/view/SMP0000077Drug actionPiroxicam (also named Feldene or Piroxicamum) is a nonsteroidal anti-inflammatory drug. Piroxicam can block prostaglandin synthesis by the action of inhibition of prostaglandin G/H synthase 1 and 2. Prostaglandin G/H synthase 1 and 2 cat...
Etodolac Action Pathway
smpdb.ca/view/SMP0000084Drug actionEtodolac is a non-steroidal anti-inflammatory drug (NSAID) that can be used to treat rheumatoid arthritis and osteoarthritis. Most NSAIDs are non-selective prostaglandin G/H synthase (a.k.a. cyclooxygenase or COX) inhibitors that act on ...
Rofecoxib Action Pathway
smpdb.ca/view/SMP0000087Drug actionRofecoxib, a non-steroidal anti-inflammatory drug (NSAID), is a highly selective inhibitor of cyclooxygenase-2 (COX-2), also known as prostaglandin G/H synthase 2. Like other NSAIDs, rofecoxib exerts its effects by inhibiting the synthes...
Pravastatin Action Pathway
smpdb.ca/view/SMP0000089Drug actionPravastatin inhibits cholesterol synthesis via the mevalonate pathway by inhibiting 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase is the enzyme responsible for the conversion of HMG-CoA to mevalonic acid, t...
Drugs: Cholecalciferol · ATP · Pravastatin · Magnesium cation · Iron · Dimethylallyl Diphosphate +9 moreRosuvastatin Action Pathway
smpdb.ca/view/SMP0000092Drug actionRosuvastatin, sold as Crestor, Rosulip and Zuvamor, belongs to the class of drugs known as statins. It is taken orally to inhibit the endogenous production of cholesterol in the liver. Statins do this by inhibiting the enzyme 3-hydroxy-3...
Drugs: Cholecalciferol · ATP · Rosuvastatin · Magnesium cation · Iron · Dimethylallyl Diphosphate +9 more