Search
Monoamine Oxidase-A Deficiency (MAO-A)
smpdb.ca/view/SMP0125595DiseaseWith the inactivation of MAO-A, 3-methoxytyramine builds up as there are no reactions that use it, and both of these paths lead to a decrease in the concentration of homovanillic acid, as there are no … and other effects.
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 moreEnzymes: Aromatic-L-amino-acid decarboxylaseTyrosinemia, Transient, of the Newborn
smpdb.ca/view/SMP0125592DiseaseThe enzymatic basis of neonatal tyrosinemia is complex and involves the susceptibility of p-hydroxyphenylpyruvic acid oxidase to inhibition in the presence of its substrate, p-hydroxyphenylpyruvic acid … The inhibition is reversible by removal of excess substrate and by reducing agents such as ascorbic acid, 2, 6-dichiorophenolindophenol, and a number of hydroquinone and phenylenediamine compounds.
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 moreEnzymes: Aromatic-L-amino-acid decarboxylasePseudoephedrine Action Pathway
smpdb.ca/view/SMP0125255Drug actionPseudophedrine also activates on beta receptors, and it inhibits sodium dependent dopamine and serotonin transporters, however not to the same effect or degree as it affects alpha receptors and the norepinephrine … Pseudoephedrine is alpha and beta agonist used to treat nasal and sinus congestion as well as allergic rhinitis. It is in many cold and sinus medicines as well as allergy medicine.
Drugs: Ascorbic acid · Norepinephrine · Pseudoephedrine · Dopamine · Calcium · Magnesium cation +1 moreEnzymes: Sodium-dependent noradrenaline transporterDopamine beta-Hydroxylase Deficiency
smpdb.ca/view/SMP0000498DiseaseNoradrenaline and adrenaline are generally not detectable in plasma, urine, and cerebrospinal fluid, but dopamine is increased 7- to 12-fold in plasma, 4-fold in urine, and 20-fold in CSF. … Treatment with dihydroxyphenylserine has been shown to reduce symptoms and signs of postural hypotension and increase plasma levels of noradrenaline.
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 moreEnzymes: Aromatic-L-amino-acid decarboxylaseDopamine beta-Hydroxylase Deficiency
smpdb.ca/view/SMP0125594DiseaseNoradrenaline and adrenaline are generally not detectable in plasma, urine, and cerebrospinal fluid, but dopamine is increased 7- to 12-fold in plasma, 4-fold in urine, and 20-fold in CSF. … Treatment with dihydroxyphenylserine has been shown to reduce symptoms and signs of postural hypotension and increase plasma levels of noradrenaline.
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 moreEnzymes: Aromatic-L-amino-acid decarboxylaseDisulfiram Action Pathway
smpdb.ca/view/SMP0000429Drug actionDisulfiram is a drug used in the treatment of cocaine addiction and chronic alcoholism. … This causes more dopamine to accumulate in the axon terminal and more dopamine is released.
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Adenosine phosphate · Tyrosine +27 moreEnzymes: Aromatic-L-amino-acid decarboxylaseCaffeine Cardiac Contraction Action Pathway
smpdb.ca/view/SMP0126520Drug actionCaffeine is a stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. … This means that much of the research is not well understood, and there is much conflicting data on caffeine.
Enzymes: Sodium/calcium exchanger 1