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Sphingolipid Signaling (Receptor)
smpdb.ca/view/SMP0524344SignalingSphingosine‑1‑phosphate (S1P) is a potent bioactive lipid mediator synthesized intracellularly by the phosphorylation of sphingosine by sphingosine kinases SphK1 and SphK2 at the plasma membrane and is then exported via spinster 2 (SPNS2...
Enzymes: Nitric oxide synthase, endothelialVEGF Signaling
smpdb.ca/view/SMP0524112SignalingCalcium activates NOS3 to produce nitric oxide, which helps with vasodilation, and also activates NFAT and Cytosolic phospholipase A2, leading to the synthesis of Prostaglandin I2 (PGI2), which aids in
Enzymes: Nitric oxide synthase, endothelialNitroglycerin Action Pathway
smpdb.ca/view/SMP0124692Drug actionNitroglycerin is converted by mitochondrial aldehyde dehydrogenase (mtALDH) to nitric oxide (NO). NO activates the enzyme guanylate cyclase.
Sildenafil Action Pathway
smpdb.ca/view/SMP0124685Drug actionSexual stimulation causes the release of nitric oxide (NO) from nerves and endothelial cells into the penis.
Metabolism and Phsyiological Effects of Asymmetric dimethylarginine (ADMA)
smpdb.ca/view/SMP0124747MetabolicADMA inhibits nitric oxide synthase, preventing the formation of nitric oxide.
Enzymes: Nitric oxide synthase, endothelialIsosorbide Mononitrate Action Pathway
smpdb.ca/view/SMP0125275Drug actionIt is then metabolized in the cytosol into nitric oxide by P450 enzymes, xanthine oxidoreductase (XO), glutathione-S-transferase (GST), or cytosolic aldehyde dehydrogenase isoforms. … Nitric oxide activates Guanylate cyclase which catalyzes GTP into cGMP. cGMP activates cGMP-dependent protein kinase. Activated protein kinase has many interactions within the myocyte.
Anti-inflammatory pathway
smpdb.ca/view/SMP0125485DiseaseAs the bacteria are cleared, tryptophan levels continue to drop as the indole dioxygenase (IDO) enzyme becomes more active. IDO activation results in the generation (from tryptophan) of kynurenine (and its other metabolites) through a se...
Nicotine Metabolism Pathway
smpdb.ca/view/SMP0000628Drug metabolismNicotine is a stimulant drug that acts as an agonist at nicotinic acetylcholine receptors. These are ionotropic receptors composed of five homomeric or heteromeric subunits. In the brain, nicotine binds to nicotinic acetylcholine recepto...
Drugs: NADH · Nicotine · Mesoheme · Flavin adenine dinucleotide · Uridine-5'-Diphosphate · FormaldehydeEnzymes: Dimethylaniline monooxygenase [N-oxide-forming] 3Streptomycin Tuberculosis Action Pathway
smpdb.ca/view/SMP0718084Drug actionThis pathway illustrates the multifaceted interactions between streptomycin—an aminoglycoside antibiotic—and Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), highlighting its antibacterial mechanism, molecular targets, and downstr...
Enzymes: Nitric oxide synthase, inducibleMethylnaltrexone Opioid Antagonist Action Pathway
smpdb.ca/view/SMP0126308Drug actionThe nitric oxide diffuses into the myocyte and causes muscle relaxation. The rythmic action of the neurotransmitters creates the peristalsis and the good GI transit.
Drugs: ATP · Nitric Oxide · Calcium · Magnesium cation · Cyclic adenosine monophosphate · Acetylcholine +2 more