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Vitamin A Deficiency
smpdb.ca/view/SMP0000336DiseaseVitamin A deficiency can be caused by many causes. A defect in the BCMO1 gene which codes for beta,beta-carotene 15,15’-monooxygenase is one of them. Beta,beta-carotene 15,15’-monooxygenase catalyzes the chemical reaction where the two s...
Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency
smpdb.ca/view/SMP0000372DiseaseAdrenal hyperplasia type 5 (AH5) also known as Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency is a rare inborn error of metabolism (IEM) and autosomal recessive disorder of cortisol and sex steroids synthesis cause...
Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency
smpdb.ca/view/SMP0000373DiseaseAdrenal hyperplasia type 3, also called Congenital adrenal hyperplasia due to 21-hydroxylase deficiency, is caused by a defect in the CYP21A2 gene which codes for Steroid 21-hydroxylase (21-hydroxylase). Steroid 21-hydroxylase catalyzes ...
11-beta-Hydroxylase Deficiency (CYP11B1)
smpdb.ca/view/SMP0000575Disease11-beta-Hydroxylase Deficiency, also called congenital adrenal hyperplasia (CAH), is an autosomal recessive disorder and caused by a defective 11-beta-hydroxylase. 11-beta-hydroxylase catalyzes the conversion of cortexolone into cortisol...
21-Hydroxylase Deficiency (CYP21)
smpdb.ca/view/SMP0000576DiseaseCongenital adrenal hyperplasia (CAH) refers to any of several autosomal recessive diseases resulting from mutations of genes for enzymes mediating the steps of biosynthesis of cortisol from cholesterol in the adrenal glands, also known a...
Corticosterone Methyl Oxidase II Deficiency (CMO II)
smpdb.ca/view/SMP0000578DiseaseCorticosterone methyloxidase type II (CMO-II) deficiency, also called 18-oxidase defiency or aldosterone deficiency II among other names, is a genetic disorder that is autosomally linked. It is caused by a mutation in the cytochrome P450...
NAD+ Signalling Pathway (Cancer)
smpdb.ca/view/SMP0083297SignalingNAD+-dependent signalling pathways regulate many fundamental processes such as DNA repair, DNA transcription, cell proliferation, cell survival, cell cycle progression, apoptosis, and metabolism. These pathways are all linked to cancer d...
Viral Sepsis
smpdb.ca/view/SMP0125490DiseaseViral sepsis begins when viral coat proteins activate the Toll-like receptors TLR4 and TLR2 on the membranes of macrophages, T-cells and dendritic cells. In addition to this protein activation, the viral DNA (or RNA if it is an RNA virus...
Corticosterone Methyl Oxidase I Deficiency (CMO I)
smpdb.ca/view/SMP0125801DiseaseCorticosterone methyloxidase type I (CMO-I) deficiency, also known as 18-hydroxylase deficiency or aldosterone deficiency among other names, is a genetic disorder that is autosomally linked and caused by a defective CYP11B2 gene. This ge...
Clobetasol propionate Action Pathway
smpdb.ca/view/SMP0126191Drug actionClobetasol propionate is a corticosteroid derived from prednisolone but with a higher specificity for glucocorticoid receptors than mineralocorticoid receptors. It is used to treat corticosteroid-responsive dermatoses and moderate to sev...
Drugs: Glutathione · Dinoprostone · Clobetasol propionate · Calcium · Prostaglandin D2 · Mesoheme +2 more