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Pleckstrin homology domain-containing family A member 4
go.drugbank.com/bio_entities/BE0001278TargetHumansBinds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides
Polypeptides: Pleckstrin homology domain-containing family A member 4Synonyms: PH domain-containing family A member 4Potassium voltage-gated channel subfamily A member 4
go.drugbank.com/bio_entities/BE0004502TargetHumansLikewise, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (PubMed:17156368) … Homotetrameric KCNA4 forms a potassium channel that opens in response to membrane depolarization, followed by rapid spontaneous channel closure (PubMed:19912772, PubMed:8495559).
Polypeptides: Potassium voltage-gated channel subfamily A member 4A disintegrin and metalloproteinase with thrombospondin motifs 4
go.drugbank.com/bio_entities/BE0004687EnzymeTargetHumansCould be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease … Cleaves aggrecan, a cartilage proteoglycan, at the '392-Glu-|-Ala-393' site and may be involved in its turnover (PubMed:10356395, PubMed:10827174). Also cleaves COMP (PubMed:39672391).
Polypeptides: A disintegrin and metalloproteinase with thrombospondin motifs 4Synonyms: ADAMTS-4, ADAM-TS 4Nuclear receptor subfamily 4 group A member 3
go.drugbank.com/bio_entities/BE0008998TargetHumansDuring inner ear, plays a role as a key mediator of the proliferative growth phase of semicircular canal development (By similarity). … Also plays a role in metabolism; by modulating feeding behavior; and by playing a role in energy balance by inhibiting the glucocorticoid-induced orexigenic neuropeptides AGRP expression, at least in part
Polypeptides: Nuclear receptor subfamily 4 group A member 3Leukocyte immunoglobulin-like receptor subfamily A member 4
go.drugbank.com/bio_entities/BE0013620TargetHumansproduction of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as a … Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+) (PubMed:16735691, PubMed:19564354
Polypeptides: Leukocyte immunoglobulin-like receptor subfamily A member 4Deficiency, Vitamin A
go.drugbank.com/conditions/DBCOND0085163Drugs: Ascorbic acid · Beta carotene · Cholecalciferol · Cod liver oil · Ergocalciferol · Vitamin A +1 moreSynonyms: Hypovitaminosis A, Deficiency, Vitamin AOngericimab
go.drugbank.com/drugs/DB18949InvestigationalOngericimab is under investigation in clinical trial NCT05325203 (A Study to Evaluate the Efficacy and Safety of JS002 in Patients With Heterozygous Familial Hypercholesterolemia (Hefh).).
Synonyms: Immunoglobulin g4, anti-(neural apoptosis-regulated convertase 1) (human monoclonal js002 .gamma.4-chain), disulfide with human monoclonal js002 .kappa.-chain, dimer, Immunoglobulin g4-kappa, anti-(homo sapienspcsk9 (proprotein convertase subtilisin/kexin type 9, neural apoptosis-regulated convertase 1, narc1, narc-1, proprotein convertase 9, pc9)), humanized monoclonalEletriptan
go.drugbank.com/drugs/DB00216ApprovedInvestigationalEletriptan is a second generation triptan drug developed by Pfizer Inc for the treatment of migraine headaches.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesProducts: RELPAX 40 MG FILM TABLET, 4 ADET, ELETRIPTAN EGAcylcarnitine (5Z)-7-[(1R,2E,5S)-5-hydroxy-2-[(2E)-oct-2-en-1-ylidene]-3-oxocyclopentyl]hept-5-enoylcarnitine
smpdb.ca/view/SMP0123485MetabolicOnce inside the cell it undergoes a reaction to form an acyl-CoA derivative called (5Z)-7-[(1R,2E,5S)-5-hydroxy-2-[(2E)-oct-2-en-1-ylidene]-3-oxocyclopentyl]hept-5-enoyl-CoA. … This reaction is facilitated by the long-chain fatty-acid CoA ligase 1 protein, which adds a CoA moiety to appropriate acyl groups.
Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 morePeginterferon alfa-2a
go.drugbank.com/drugs/DB00008ApprovedInvestigationalPeginterferon alfa-2a is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). … When combined together, Peginterferon alfa-2a and [DB00811] have been shown to achieve a SVR between 36% for genotype 1 and 59% for genotypes 2-6 after 48 weeks of treatment.
Categories: Compounds used in a research, industrial, or household setting, Interferon Type ISynonyms: PEG-IFN alfa-2A, PEG-Interferon alfa-2A