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Displaying results 461 - 470 of 10000 in total
  1. Pathway

    Metabolism and Physiological Effects of Kynurenine

    smpdb.ca/view/SMP0125524
    Disease

    In the blood it travels to the liver and is transported into a hepatocyte by an amino acid transporter. … Kynurenine is shown to activate aryl hydrocarbon receptors that can lead to renal impairment, apoptosis, and kynurenine has also been found to disrupt the electron transport chain and oxidative phosphorylation

    Drugs: Tryptophan · Formic acid · Kynurenine · Mesoheme
    Enzymes: Neutral and basic amino acid transport protein rBAT
  2. Pathway

    Metabolism and Physiological Effects of Isovalerylglycine

    smpdb.ca/view/SMP0126748
    Metabolic

    its isomer, pivaloylcarnitine; pivaloylcarnitine is derived from pivalate-generating antibiotics, and has caused many false-positive results. … important to caution for false positive results when screening for isovaleric acidemia by tandem mass spectrometry based on dried blood-spot levels of C5-acylcarnitines, including isovalerylcarnitine and

    Drugs: Glycine · Proline
  3. Pathway

    Metabolism and Physiological Effects of Tiglylglycine

    smpdb.ca/view/SMP0126840
    Metabolic

    Tiglylglycine is an intermediate product of the catabolism of isoleucine. … An elevated level of tiglylglycine is identified in urine of patients with beta-ketothiolase deficiency or with disorders of propionate metabolism.

    Drugs: Glutamic acid · Glycine · Isoleucine · Oxogluric acid · Flavin adenine dinucleotide
  4. Pathway

    Metabolism and Physiological Effects of Citrulline

    smpdb.ca/view/SMP0126861
    Metabolic

    Citrulline has also been detected, but not quantified in several different foods, such as epazotes, lotus, common buckwheats, strawberry guava, and italian sweet red peppers. … wax beans, and potato.

    Drugs: Ornithine · Glycine · Citrulline
  5. Drug

    Pentaerythritol tetranitrate

    go.drugbank.com/drugs/DB06154
    ApprovedWithdrawn

    It is formed by reacting pentaerythritol (C5H12O4), an alcohol commonly used in paints and varnishes, with nitric acid (HNO2). The reacting solution is chilled to precipitate the PETN. … It is recognized by the FDA to be a coronary vasodilator in the treatment of heart conditions such as angina [L2395].

    Products: Peritrate Tab 20mg, Peritrate Tab 10mg
  6. Drug

    Chlorpropamide

    go.drugbank.com/drugs/DB00672
    ApprovedWithdrawn

    It belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. … Chlorpropamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM).

    Categories: Alimentary Tract and Metabolism, Genito Urinary System and Sex HormonesSynonyms: N-(4-chlorophenylsulfonyl)-N'-propylurea, N-(p-chlorobenzenesulfonyl)-N'-propylurea
  7. Drug

    Rupatadine

    go.drugbank.com/drugs/DB11614
    ApprovedInvestigational

    It was approved for marketing in Canada under the tradename Rupall and comes in tablet formulation for adult use and liquid formulation for pediatric use. … Rupatadine is a dual histamine H1 receptor and platelet activating factor receptor antagonist that is used for symptomatic relief in seasonal and perennial rhinitis as well as chronic spontaneous urticaria

    Categories: Histamine H1 Antagonists, Non-SedatingProducts: RUPAFIN 10MG, URTIMED 10MG
  8. Pathway

    Metabolism and Physiological Effects of Putrescine

    smpdb.ca/view/SMP0123276
    Metabolic

    While putrescine is important for interactions and processes involving, DNA, RNA and proteins, at high levels it is also a protein bound uremic toxin found in the body that can inhibit erythropoietin production … Like other polyamines such as spermidine and spermine, putrescine can also be obtained directly from diet as well.

    Drugs: Arginine · Ornithine · Putrescine · Urea
  9. Pathway

    Metabolism and Physiological Effects of Xanthosine

    smpdb.ca/view/SMP0124866
    Metabolic

    The purines are guanine and adenine. These undergo metabolism in the liver to form xanthosine. Adenine forms adenosine through the enzyme purine nucleoside phosphorylase. … Xanthosine then enters the blood where it can have detrimental effects on other organs such as the kidney, causing renal failure and the heart causing cardiovascular disease.

    Drugs: Adenine · Adenosine · Zinc · Xanthine · Guanine · Ribose-1-Phosphate +3 more
  10. Pathway

    Metabolism and Physiological Effects of Uridine

    smpdb.ca/view/SMP0124871
    Metabolic

    More specifically, uridine is a nucleoside consisting of uracil and D-ribose and a component of RNA. … L-glutamine is first converted to carbamoyl phosphate then to N-Carbamoyl-L-aspartate and finally to dihydroorotate by the CAD protein (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and

    Drugs: Aspartic acid · L-Glutamine · ATP · Magnesium cation · Zinc · Uridine +3 more