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Displaying results 4781 - 4790 of 10000 in total
  1. Target

    Glutamyl aminopeptidase

    go.drugbank.com/bio_entities/BE0002271
    TargetHumans

    Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II

    Synonyms: AP-A, Aminopeptidase A
  2. Pathway

    Sialuria or French Type Sialuria

    smpdb.ca/view/SMP0000217
    Disease

    Sialuria is caused by mutation in the gene encoding uridinediphosphate-N-acetylglucosamine 2-epimerase (UDP-GlcNAc 2-epimerase, which causes an excessive synthesis of sialic acid (N-acetylneuraminic acid, NeuAc). This causes accumulation...

    Drugs: Pyruvic acid · L-Glutamine · N-Acetylglucosamine · Glutamic acid · ATP · Glucosamine +6 more
  3. Pathway

    2-Ketoglutarate Dehydrogenase Complex Deficiency

    smpdb.ca/view/SMP0000549
    Disease

    2-Ketoglutarate dehydrogenase complex deficiency, also known as alpha-ketoglutarate dehydrogenase deficiency or oxoglutaric aciduria, is an autosomal recessive disorder of the Krebs cycle caused by a defective … This disorder is characterized by a large accumulation of 2-ketoglutarate in the urine. Symptoms of the disorder include opisthotonus, ataxia, developmental delay, and seizures.

    Drugs: Pyruvic acid · Biotin · Succinic acid · NADH · ATP · Magnesium cation +4 more
    Enzymes: Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial, Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
  4. Pathway

    Sialuria or French Type Sialuria

    smpdb.ca/view/SMP0125712
    Disease

    Sialuria is caused by mutation in the gene encoding uridinediphosphate-N-acetylglucosamine 2-epimerase (UDP-GlcNAc 2-epimerase, which causes an excessive synthesis of sialic acid (N-acetylneuraminic acid, NeuAc). This causes accumulation...

    Drugs: Pyruvic acid · L-Glutamine · N-Acetylglucosamine · Glutamic acid · ATP · Glucosamine +7 more
  5. Indication

    Fever

    go.drugbank.com/conditions/DBCOND0020923
    Drugs: Acetaminophen · Acetylsalicylic acid · Ascorbic acid · Brompheniramine · Caffeine · Chlorpheniramine +20 more
    Synonyms: Has a temperature
  6. Drug

    Isopropyl alcohol

    go.drugbank.com/drugs/DB02325
    ApprovedInvestigational

    An isomer of 1-propanol. It is a colorless liquid having disinfectant properties. It is used in the manufacture of acetone and its derivatives and as a solvent. Topically, it is used as an antiseptic.

    Mixtures: Sooth-a-Sting, CVS Health Healing on the Go KitCategories: Compounds used in a research, industrial, or household setting
  7. Drug

    Ibuprofen

    go.drugbank.com/drugs/DB01050
    ApprovedInvestigational

    [A39076] On the available products, ibuprofen is administered as a racemic mixture. … Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics.

    Synonyms: (±)-α-methyl-4-(2-methylpropyl)benzeneacetic acid, (±)-2-(p-isobutylphenyl)propionic acidInternational brands: Act-3, Alges-X
  8. Target

    Uncharacterized MFS-type transporter EfpA

    go.drugbank.com/bio_entities/BE0009715
    TargetMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

    Synonyms: Efflux protein A
  9. Drug

    Docetaxel

    go.drugbank.com/drugs/DB01248
    ApprovedInvestigational

    Docetaxel is a complex diterpenoid molecule and a semisynthetic analogue of [paclitaxel]. … Docetaxel is a clinically well established anti-mitotic chemotherapy medication used for the treatment of different types of cancer, including breast, ovarian, and non-small cell lung cancer.

    Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexSynonyms: N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol, N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetylpaclitaxel
  10. Indication

    Febrile Illness Acute

    go.drugbank.com/conditions/DBCOND0059951
    Drugs: Acetaminophen
    Synonyms: Has a temperature