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Metabolism and Physiological Effects of Phenol sulphate
smpdb.ca/view/SMP0126844MetabolicIn experimental models of diabetes, phenol sulphate administration has been shown to induce albuminuria and podocyte damage. … Phenol sulphate can be found in most mammals (mice, rats, sheep, dogs, humans) and likely most animals. Phenol sulphate is a uremic toxin.
Metabolism and Physiological Effects of Androsterone sulfate
smpdb.ca/view/SMP0127012MetabolicAndrosterone sulfate (Andros-S) is the most abundant 5-alpha-reduced androgen metabolite in serum. … Subsequently, 3α-androstanediol and 3α-etiocholanediol are converted by 17β-HSD into androsterone and etiocholanolone, which is followed by their conjugation and excretion.
Drugs: TestosteroneEnzymes: 3-oxo-5-alpha-steroid 4-dehydrogenase 12-Hydroxyglutric Aciduria (D and L Form)
smpdb.ca/view/SMP0000136DiseaseA deficiency in this enzyme results in accumulation of L-2-Hydroxyglutaric acid in plasma, spinal fluid, and urine; and L-lysine in plasma and spinal fluid. … A deficiency in this enzyme results in accumulation of D-2-Hydroxyglutaric acid in plasma, spinal fluid, and urine; oxoglutaric acid in urine; and gabba-aminobutyric acid in spinal fluid.
Drugs: Pyridoxal phosphate · Pyruvic acid · Biotin · Aspartic acid · L-Glutamine · Adenosine phosphate +17 moreIntracellular Signalling Through Prostacyclin Receptor and Prostacyclin
smpdb.ca/view/SMP0000354SignalingProstacyclin binding to its receptor increases vasodilation and decreases platelet aggregation. … The receptor is a G-protein coupled receptor, upon its binding it activates G proteins causing the activation of adenylyl cyclase and production of cAMP messenger molecules. cAMP activates PKA (protein
Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortMetabolism and Physiological Effects of Phenyl sulfate
smpdb.ca/view/SMP0123213MetabolicPhenyl sulphate is shown to cause albuminuria and diabetic kidney disease. … Phenyl sulphate is a phenolic compound that is formed through gut microbial metabolism from dietary tyrosine and a sulfation reaction in liver hepatic cells.
Metabolism and Physiological Effects of Para-cresol
smpdb.ca/view/SMP0123214MetabolicP-cresol is shown to be associated with cardiovascular disease and it can also inhibit endothelial cell proliferation. … P-cresol can then undergo sulfation or glucuronidation reactions in the liver to produce the uremic toxins p-cresyl sulfate and p-cresyl glucuronide respectively.
Metabolism and Physiological Effects of Indoxyl Sulfate
smpdb.ca/view/SMP0123237MetabolicIt is also shown to cause vascular calcification and disrupt the electron transport chain and oxidative phosphorylation causing muscle atrophy … Indoxyl sulfate is an indole compound that is formed through gut microbial metabolism from dietary tryptophan and a sulfation reaction in liver hepatic cells.
Metabolism and Physiological Effects of Phenylacetic Acid
smpdb.ca/view/SMP0123256MetabolicL-Phenylalanine is consumed through high protein foods such as eggs, chicken, liver, beef, milk, and soybeans. … It reduces nitric oxide production and reduces protection against inflammation in vessel walls. It also leads to the production of reactive oxygen species.
Metabolism and Physiological Effects of Orotic acid
smpdb.ca/view/SMP0124870MetabolicL-glutamine is first converted to carbamoyl phosphate then to N-Carbamoyl-L-aspartate and finally to dihydroorotate by the CAD protein (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and … It originates from l-glutamine, which is obtained from protein sources such as red meat and eggs in the diet. L-glutamine is metabolized to orotate in the liver.
Metabolism and Physiological Effects of N-Acetylserine
smpdb.ca/view/SMP0126556MetabolicN-acyl-alpha amino acids are compounds containing an alpha amino acid which bears an acyl group at its terminal nitrogen atom. … N-Acetylserine can also be classified as an alpha amino acid or a derivatized alpha amino acid.
Enzymes: N-alpha-acetyltransferase 15, NatA auxiliary subunit