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Pafolacianine Action Pathway
smpdb.ca/view/SMP0126305Drug actionPafolacianine is a folate analogue used for the treatment of ovarian cancer. It targets the folate receptor in cancer cells where they are overexpressed. Pafolacianine binds to the receptor and is absorbed via receptor-mediated endocytos...
Segawa Syndrome
smpdb.ca/view/SMP0125587DiseaseTetrahydrobiopterin is an important compound in the production of neurotransmitters, specifically dopamine and serotonin, and the processing of quite a few amino acids, The mutation on GCH1 causes GTP
Enzymes: Aromatic-L-amino-acid decarboxylaseAndrostenedione Metabolism
smpdb.ca/view/SMP0030406MetabolicThe last reaction to form androsterone glucuronide is catalyzed by the large multimer UDP-glucuronosyltransferase 1-1.
Pralatrexate Action Pathway
smpdb.ca/view/SMP0126296Drug actionPralatrexate is a folate analog, used for the treatment of peripheral T-cell lymphoma. Administered intravenously it acts to inhibit dihydrofolate reductase, specifically in cancer cells that have an overexpression of a transporter known...
Pemetrexed Action Pathway
smpdb.ca/view/SMP0126261Drug actionOnce inside the cell via a folate transporter, it is converted to by folylpolyglutamate synthétase into its polyglutamate form. … This new form is better retained in the cells and goes on to inhibit enzymes such as dihydrofolate reductase, thymidylate synthase and bifunctional purine biosynthesis protein (PURH).
Naftifine Action Pathway
smpdb.ca/view/SMP0125827Drug actionNaftifine is an antifungal agent used to treat infections of the Tinea, Trichophyton, and Epidermophyton species. It is used as a topical treatment of tinea pedis, tinea cruris, and tinea corporis caused by the organisms Trichophyton rub...
Drugs: Naftifine · Magnesium cation · Formic acid · Mesoheme · Flavin adenine dinucleotide · Ergosterol +2 moreRaltitrexed Action Pathway
smpdb.ca/view/SMP0126304Drug actionRaltitrexed is a folate analog that is used in the treatment of colorectal cancer, that is an inhibitor of thymidylate synthase. Inhibiting thymidylate synthase stops the proliferation of cancer cells, as it stops the production and form...
Butenafine Action Pathway
smpdb.ca/view/SMP0125811Drug actionButenafine is a topical antifungal used to treat tinea versicolor, tinea pedis, tinea cruris, and tinea corporis due to the fungi E. floccosum, T. mentagrophytes, T. rubrum, and T. tonsurans.The exact mechanism of action has not been est...
Drugs: Butenafine · Magnesium cation · Formic acid · Mesoheme · Flavin adenine dinucleotide · Ergosterol +2 moreSepiapterin Reductase Deficiency
smpdb.ca/view/SMP0125588DiseaseSepiapterin reductase deficiency is a genetic disorder that is characterized by abnormal levels of neurotransmitters and pterins. It is caused an autosomal recessive genetic mutation in the SPR gene which leads to the underproduction of ...
Enzymes: Aromatic-L-amino-acid decarboxylaseFolate Metabolism
smpdb.ca/view/SMP0000053MetabolicFrom there, dihydrofolate reductase converts folic acid into dihydrofolic acid. Dihydrofolic acid is then created into tetrahydrofolic acid through dihydrofolate reductase. … Many countries around the world now fortify foods with folic acid to prevent such defects.