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Interferon gamma receptor 1
go.drugbank.com/bio_entities/BE0000711TargetHumansAssociates with transmembrane accessory factor IFNGR2 to form a functional receptor (PubMed:10986460, PubMed:2971451, PubMed:7615558, PubMed:7617032, PubMed:7673114). … Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (PubMed:20015550
Polypeptides: Interferon gamma receptor 1Synonyms: IFN-gamma receptor 1, Interferon gamma receptor alpha-chainMu-type opioid receptor
go.drugbank.com/bio_entities/BE0000770TargetHumansThe phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins (By similarity). … Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G protein coupling (By similarity).
Polypeptides: Mu-type opioid receptorSynonyms: Mu opiate receptor, Mu opioid receptor5-hydroxytryptamine receptor 1B
go.drugbank.com/bio_entities/BE0000797TargetHumansG protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:10452531, PubMed:1315531, PubMed:1328844, PubMed:1348246, PubMed:1351684, PubMed:1559993, PubMed:1565658, PubMed:1610347, PubMed:23519210 … Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD) (PubMed:23519210, PubMed
Polypeptides: 5-hydroxytryptamine receptor 1BSynonyms: Serotonin receptor 1B, Serotonin 1D beta receptorMetabotropic glutamate receptor 7
go.drugbank.com/bio_entities/BE0000834TargetHumansG protein-coupled receptor activated by glutamate that regulates axon outgrowth through the MAPK-cAMP-PKA signaling pathway during neuronal development (PubMed:33500274).
Polypeptides: Metabotropic glutamate receptor 7Hydroxycarboxylic acid receptor 3
go.drugbank.com/bio_entities/BE0000836TargetHumansG protein-coupled receptor for 3-hydroxyoctanoate, a fatty acid beta-oxidation intermediate. … Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet (PubMed:12522134)
Polypeptides: Hydroxycarboxylic acid receptor 3Synonyms: Niacin receptor 2, Nicotinic acid receptor 2Proteinase-activated receptor 1
go.drugbank.com/bio_entities/BE0000928TargetHumansHigh affinity receptor that binds the activated thrombin, leading to calcium release from intracellular stores (PubMed:1672265, PubMed:8136362). … The thrombin-activated receptor signaling pathway is mediated through PTX-insensitive G proteins, activation of phospholipase C resulting in the production of 1D-myo-inositol 1,4,5-trisphosphate (InsP3
Polypeptides: Proteinase-activated receptor 1Synonyms: Thrombin receptor, Coagulation factor II receptor5-hydroxytryptamine receptor 6
go.drugbank.com/bio_entities/BE0000945TargetHumansG protein-coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:35714614, PubMed:36989299, PubMed:37327704, PubMed
Polypeptides: 5-hydroxytryptamine receptor 6Synonyms: Serotonin receptor 6Beta-3 adrenergic receptor
go.drugbank.com/bio_entities/BE0001012TargetHumansG protein-coupled receptor for catecholamines that couples to both G(s) and G(i) proteins, leading to either activation or inhibition of adenylate cyclase and cAMP-dependent pathway, respectively (PubMed
Polypeptides: Beta-3 adrenergic receptorFunction: beta-adrenergic receptor activityOxysterols receptor LXR-beta
go.drugbank.com/bio_entities/BE0001598TargetHumansNuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920).
Polypeptides: Oxysterols receptor LXR-betaSynonyms: Liver X receptor beta, Nuclear receptor NEREstrogen-related receptor gamma
go.drugbank.com/bio_entities/BE0002088TargetHumansOrphan receptor that acts as a transcription activator in the absence of bound ligand.
Polypeptides: Estrogen-related receptor gammaSynonyms: Estrogen receptor-related protein 3, Nuclear receptor subfamily 3 group B member 3