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Terbinafine Action Pathway
smpdb.ca/view/SMP0125118Drug actionTerbinafine (commonly known as Lamisil or Silka cream) is a synthetic allylamine anti-fungal used mainly for athletes foot and other fungal skin infections. While Terbinafine is most commonly used against the fungus species Trichophyton ...
Drugs: Terbinafine · Magnesium cation · Formic acid · Mesoheme · Flavin adenine dinucleotide · Ergosterol +2 moreTolnaftate Action Pathway
smpdb.ca/view/SMP0125360Drug actionTolnaftate is an over-the-counter anti-fungal agent mainly used to treat jock itch, athlete's foot and ringworm. It can come as a cream, powder, spray, or liquid aerosol. Tolnaftate is diffuses into the fungal cell. The exact mechanism o...
Drugs: Tolnaftate · Magnesium cation · Formic acid · Mesoheme · Flavin adenine dinucleotide · Ergosterol +2 moreMiconazole Action Pathway
smpdb.ca/view/SMP0125822Drug actionThis molecule participates in quorum sensing in Candida, preventing the transition from yeast to mycelial forms and thereby the formation of biofilms, which are more resistant to antibiotics.
Drugs: Miconazole · Magnesium cation · Formic acid · Mesoheme · Flavin adenine dinucleotide · Ergosterol +2 moreMevalonic Aciduria
smpdb.ca/view/SMP0000510DiseaseIt is manifested by high levels of mevalonic acid in the urine and other body fluids. Approximately 30 patients with mevalonic aciduria (MVA) have been reported worldwide. … MVA is classified as a disorder of branched-chain organic acid metabolism because the substrate for the reaction with mevalonate kinase, HMG-CoA, is a product of leucine catabolism.
Drugs: Cholecalciferol · ATP · Magnesium cation · Iron · Dimethylallyl Diphosphate · Formic acid +8 moreEnzymes: Lysosomal acid lipase/cholesteryl ester hydrolaseMevalonic Aciduria
smpdb.ca/view/SMP0125643DiseaseIt is manifested by high levels of mevalonic acid in the urine and other body fluids. Approximately 30 patients with mevalonic aciduria (MVA) have been reported worldwide. … MVA is classified as a disorder of branched-chain organic acid metabolism because the substrate for the reaction with mevalonate kinase, HMG-CoA, is a product of leucine catabolism.
Drugs: Cholecalciferol · ATP · Magnesium cation · Iron · Dimethylallyl Diphosphate · Formic acid +8 moreEnzymes: Lysosomal acid lipase/cholesteryl ester hydrolaseFolate Malabsorption, Hereditary
smpdb.ca/view/SMP0000724DiseaseHereditary folate malabsorption, also known as folic acid transport defect, is an extremely rare inborn error of metabolism (IEM) and autosomal recessive disorder of the folate metabolism pathway.
Folate Malabsorption, Hereditary
smpdb.ca/view/SMP0125747DiseaseHereditary folate malabsorption, also known as folic acid transport defect, is an extremely rare inborn error of metabolism (IEM) and autosomal recessive disorder of the folate metabolism pathway.
Methotrexate Action Pathway
smpdb.ca/view/SMP0000432Drug actionBoth methotrexate and methotrexate-polyglutamate inhibit dihydrofolate reductase, an enzyme that catalyzes the conversion of dihydrofolate into tetrahydrofolate, which is the active form of folic acid.
17-beta Hydroxysteroid Dehydrogenase III Deficiency
smpdb.ca/view/SMP0125781Disease17-beta hydroxysteroid dehydrogenase III deficiency, also known as 17-KSR deficiency or male pseudohermaphroditism with gynecomastia (MPH), is as rare inborn error of metabolism (IEM) and autosomal recessive disorder of the androgen and ...
Smith-Lemli-Opitz Syndrome (SLOS)
smpdb.ca/view/SMP0000389DiseaseSLOS causes the accumulation of 7-dehydrocholesterol and 8-dehydrocholesterol, and a decrease of cholesterol in plasma; and 3-methylglutaconic acid in urine.
Drugs: Cholecalciferol · ATP · Magnesium cation · Iron · Dimethylallyl Diphosphate · Formic acid +8 moreEnzymes: Lysosomal acid lipase/cholesteryl ester hydrolase