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Displaying results 51 - 60 of 818 in total
  1. Indication

    Hypokalemia

    go.drugbank.com/conditions/DBCOND0003942
    Drugs: Amiloride · Potassium · Potassium acetate · Potassium aspartate · Potassium bicarbonate · Potassium chloride +2 more
    Synonyms: Low potassium, Low potassium syndrome
  2. Target

    Solute carrier family 12 member 1

    go.drugbank.com/bio_entities/BE0000502
    TargetTransporterHumans

    Renal sodium, potassium and chloride non-electrogenic ion symporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration … and volume regulation (PubMed:21321328).

    Synonyms: Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1
  3. Target

    Solute carrier family 12 member 2

    go.drugbank.com/bio_entities/BE0000281
    TargetTransporterHumans

    Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:33597714 … Plays a vital role in the regulation of ionic balance and cell volume (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:7629105)

    Synonyms: Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2
  4. Drug

    Triamterene

    go.drugbank.com/drugs/DB00384
    Approved

    It works by promoting the excretion of sodium ions and water while decreasing the potassium excretion in the distal part of the nephron in the kidneys by working on the lumenal side. … [L6163] Currently, triamterene is used in the treatment of edema associated with various conditions as monotherapy and is approved for use with other diuretics to enhance diuretic and potassium-sparing

    Mixtures: Triamterene and Hydrochlorothiazide, Triamterene and HydrochlorothiazideCategories: Potassium-Sparing Diuretics, Sodium Channel Blockers
  5. Drug

    Benzthiazide

    go.drugbank.com/drugs/DB00562
    Approved

    Thiazides also cause loss of potassium and an increase in serum uric acid. … Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.

    Categories: Sodium Chloride Symporter Inhibitors, Genito Urinary System and Sex Hormones
  6. Drug

    Lubiprostone

    go.drugbank.com/drugs/DB01046
    ApprovedInvestigational

    Activation of these channels promotes the secretion of a chloride-rich fluid that soften the stool, increase gastrointestinal motility, and induce spontaneous bowel movements (SBM). … A prostaglandin E1 derivative, lubiprostone is a bicyclic fatty acid that activates ClC-2 chloride channels located on the apical side of the gastrointestinal epithelial cells.

    Categories: Chloride Channel Agonists, Alimentary Tract and Metabolism
  7. Indication

    Skin and subcutaneous tissue infections and infestations

    go.drugbank.com/conditions/DBCOND0027759
    Drugs: Amoxicillin · Ceftazidime · Cephalexin · Clavulanic acid · Erythromycin · Metronidazole +3 more
    Synonyms: Skin and subcutaneous tissue infections and infestations, Skin and skin-structure infection
  8. Drug

    Dextrose, unspecified form

    go.drugbank.com/drugs/DB09341
    ApprovedInvestigationalVet approved

    It circulates in human circulation as blood glucose and acts as an essential energy source for many organisms through aerobic or anaerobic respiration and fermentation. … L-glucose is a synthesized enantiomer that is used as a low-calorie sweetener and laxative.

    Mixtures: Potassium Chloride in Dextrose and Sodium Chloride, Potassium Chloride in Dextrose and Sodium ChlorideProducts: %5 DEKSTROZ %0.9 SODYUM KLORÜR ÇÖZELTİSİ 500 ML (ŞİŞE) SETSİZ, %5 DEKSTROZ %0.9 SODYUM KLORÜR ÇÖZELTİSİ 1000 ML (ŞİŞE) SETSİZ
  9. Drug

    Metolazone

    go.drugbank.com/drugs/DB00524
    ApprovedInvestigational

    It also tends to lower blood pressure and increase potassium loss.

    Categories: Sodium Chloride Symporter Inhibitors, metolazone and potassium-sparing agents
  10. Drug

    Bendroflumethiazide

    go.drugbank.com/drugs/DB00436
    ApprovedInvestigational

    A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders.

    Mixtures: Nadolol and Bendroflumethiazide, Nadolol and BendroflumethiazideCategories: Sodium Chloride Symporter Inhibitors, bendroflumethiazide and potassium