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Displaying results 61 - 70 of 122 in total
  1. Pathway

    Hawkinsinuria

    smpdb.ca/view/SMP0000190
    Disease

    pyroglutamic acid in urine; and L-tyrosine in plasma. … Symptoms include ketosis, metabolic acidosis, swimming-pool odor, and mental retardation. Treatment includes a low-protein diet and vitamin C.

    Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 more
  2. Pathway

    Disulfiram Action Pathway

    smpdb.ca/view/SMP0000429
    Drug action

    Disulfiram is a drug used in the treatment of cocaine addiction and chronic alcoholism. … This causes more dopamine to accumulate in the axon terminal and more dopamine is released.

    Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Adenosine phosphate · Tyrosine +27 more
  3. Pathway

    Duloxetine (SNRI) - Norepinephrine Reuptake Inhibiton

    smpdb.ca/view/SMP0125000
    Drug action

    The receptors that are being stimulated are 5-HT 2A, 2B, and 2C serotonin receptors and alpha 1 and beta 1 adrenergic receptors. … Stimulation of the 2A, 2B and 3C receptor can increase cognitive abilities like learning, appetite, memory, mood and sleep.

    Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Norepinephrine · Duloxetine · Dopamine +4 more
  4. Pathway

    Methyldopa Action Pathway

    smpdb.ca/view/SMP0125087
    Drug action

    Two types of alpha receptors, alpha 1 and alpha 2, both play a role in regulating blood pressure. … Phospholipase C converts phosphatidylinositol 4,5-bisphosphate to diacylglycerol and inositol 1,4,5-trisphosphate (IP3).

    Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Sapropterin · Norepinephrine · Dopamine +5 more
  5. Pathway

    Norepinephrine Alpha 1A Adrenergic Blood Vessel Relaxation Action Pathway

    smpdb.ca/view/SMP0125166
    Drug action

    When taken pharmacologically it acts on the sympathetic nervous system in the heart and the blood vessels. It is mainly used pharmacologically for hypotension and vasodilatory shock states. … This enzyme catalyzes Myosin light chain 3 into myosin LC-P which causes myosin to bind to actin and contract the muscle cell.

    Drugs: ATP · Norepinephrine · Calcium · Magnesium cation
  6. Pathway

    Caffeine Nervous Action Pathway

    smpdb.ca/view/SMP0125297
    Drug action

    more.Therefore arousal and wakefulness inhibits sleep, and sleep inhibits arousal and wakefullness. … Norepinephrine accumulates in the synapse and activates Alpha-1 adrenergic receptors and beta-1 adrenrgic receptors.

    Drugs: Pyridoxal phosphate · Glutamic acid · Caffeine · Norepinephrine · Adenosine · Calcium +1 more
  7. Pathway

    Tyrosinemia Type I

    smpdb.ca/view/SMP0125591
    Disease

    of tyrosine in the liver and kidneys. … Symptoms of tyrosinemia type I include jaundice and an enlarged liver, kidney dysfunction, as well as a failure to grow, as foods with high protein and amino acids lead to increased symptoms.

    Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 more
  8. Pathway

    Monoamine Oxidase-A Deficiency (MAO-A)

    smpdb.ca/view/SMP0125595
    Disease

    and other effects. … Since serotonin helps to regulate emotions and mood, with epinephrine and norepinephrine regulating stress, the unnecessary presence of the chemicals in the brain can lead to poor impulse control, aggression

    Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 more
  9. Pathway

    Tyrosine Hydroxylase Deficiency

    smpdb.ca/view/SMP0125611
    Disease

    Dopamine transmits signals to help the brain control physical movement and emotional behavior. Norepinephrine and epinephrine are involved in the autonomic nervous system. … As a result, the body produces less dopamine, norepinephrine and epinephrine. Symptoms of the disorder include abnormal movements, autonomic dysfunction, and other neurological problems.

    Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Tyrosine · Norepinephrine · Epinephrine +4 more
  10. Pathway

    Maprotiline Action Pathway

    smpdb.ca/view/SMP0126344
    Drug action

    Maprotiline acts as an antagonist at central presynaptic α2-adrenergic inhibitory autoreceptors and hetero-receptors, an action that is postulated to result in an increase in central noradrenergic and … This tetracyclic molecule strongly inhibits neuronal norepinephrine reuptake in the brain and peripheral tissues.

    Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Sapropterin · Norepinephrine · Maprotiline +5 more