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Displaying results 811 - 820 of 10000 in total
  1. Target

    Neuronal Acetylcholine (nACh) Receptor Subunits

    go.drugbank.com/bio_entities/BE0009927
    TargetHumans

    by a collection of nAChR subunits. … Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability. nAChRs are excitatory neurotrasnmitter receptors formed

    Synonyms: nAChR7, NACHR alpha-10
  2. Drug

    Omeprazole

    go.drugbank.com/drugs/DB00338
    ApprovedInvestigationalVet approved

    Originally approved by the FDA in 1989, omeprazole is a _proton-pump inhibitor_, used to treat gastric acid-related disorders. … Omeprazole is generally effective and well-tolerated, promoting its popular use in children and adults [FDA label].

    Mixtures: ORAZOLE ® 10 MG CAPSULACategories: P-glycoprotein inhibitors, P-glycoprotein substrates
  3. Target

    Prostaglandin E synthase

    go.drugbank.com/bio_entities/BE0011075
    TargetHumans

    Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inf...

    Synonyms: Microsomal glutathione S-transferase 1-like 1
  4. Drug

    Aluminum zirconium octachlorohydrex gly

    go.drugbank.com/drugs/DB11200
    Approved

    Aluminum zirconium octachlorohydrex gly is complex that consists of aluminum zirconium octachlorohydrate and glycine. It is an active antiperspirant agent [L2705], [L2706].

    Mixtures: Ron 2Products: Old Spice GentleMan s Blend Mandarin and Musk, Old Spice GentleMan s Blend Aloe and Wild Sage
  5. Target

    Flavin reductase (NADPH)

    go.drugbank.com/bio_entities/BE0000595
    TargetEnzymeHumans

    from S-nitroso-CoA to Cys-109 and Cys-188 residues of BLVRB and from S-nitroso-BLVRB to the protein substrate (PubMed:38056462). … S-nitroso-CoA-dependent nitrosyltransferase activity is mediated via a 'ping-pong' mechanism: BLVRB first associates with both S-nitroso-CoA and protein substrate, nitric oxide group is then transferred

    Synonyms: S-nitroso-CoA-assisted nitrosyltransferase
  6. Pathway

    Spermidine and Spermine Biosynthesis

    smpdb.ca/view/SMP0000445
    Metabolic

    Spermidine is subsequently processed into spermine by spermine synthase in the presence of the aminopropyl donor, S-adenosylmethioninamine. … Spermidine originates from the action of spermidine synthase, which converts the methionine derivative S-adenosylmethionine and the ornithine derivative putrescine into spermidine 5'-methylthioadenosine

    Drugs: Pyridoxal phosphate · Ademetionine · Spermine · Ornithine · Methionine · ATP +6 more
    Enzymes: S-adenosylmethionine decarboxylase proenzyme, S-adenosylmethionine synthase isoform type-2
  7. Drug

    Acetaminophen

    go.drugbank.com/drugs/DB00316
    ApprovedInvestigational

    Acetaminophen (paracetamol), also commonly known as _Tylenol_, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization … while this drug is taken or prescribed.

    Synonyms: N-acetyl-p-aminophenol, 4-acetamidophenolInternational brands: Dapa X-S, St. Joseph Fever Reducer
  8. Drug

    Navepegritide

    go.drugbank.com/drugs/DB17824
    ApprovedInvestigational

    [L56065] Navepegritide was approved by the US FDA in February 2026 for use in patients 2 years of age and older with achondroplasia with open epiphyses.[L56058,L56065] … [L56058,A275435] Navepegritide is a prodrug of active C-type natriuretic peptide (CNP) consisting of a CNP moiety transiently conjugated to two methoxy polyethylene glycol (mPEG) moieties via a proprietary

  9. Drug

    Gabapentin

    go.drugbank.com/drugs/DB00996
    ApprovedInvestigational

    [L8717] It was originally developed as a novel anti-epileptic for the treatment of certain types of seizures[A186277,A186143] - today it is also widely used to treat neuropathic pain. … [A14097,A186179] Gabapentin has some stark advantages as compared with other anti-epileptics, such as a relatively benign adverse effect profile, wide therapeutic index, and lack of appreciable metabolism

    Mixtures: Innoprax-5, GAVINDO NSynonyms: 1-(Aminomethyl)cyclohexaneacetic acid
  10. Pathway

    Cystathionine beta-Synthase Deficiency

    smpdb.ca/view/SMP0000177
    Disease

    Cystathionine Beta-Synthase Deficiency (CBS Deficiency; Homocystinuria) is an autosomal recessive disease caused by a mutation in the CBS gene which codes for cystathionine beta-synthase. A deficiency in this enzyme results in accumulati...

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Choline · Adenosine phosphate · Serine +17 more
    Enzymes: S-adenosylmethionine decarboxylase proenzyme, S-methyl-5'-thioadenosine phosphorylase