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Displaying results 81 - 90 of 134093 in total
  1. Pathway

    Metabolism and Physiological Effects of Para-cresyl glucuronide

    smpdb.ca/view/SMP0123299
    Metabolic

    After being transported into gut microbes, tyrosine undergoes reactions with the enzymes tyrosine transaminase, 4-hydroxyphenylpyruvate oxidase and 4-hydroxylphenylacetate decarboxylase to form para-cresol … Most of the p-cresol that is produced from the gut microbes then enters systemic circulation and is converted into P-cresyl sulphate by the liver.

    Drugs: Tyrosine · P-Cresol · 4-Hydroxyphenylpyruvic acid
  2. Pathway

    Metabolism and Physiological Effects of 4-Hydroxyhippuric Acid

    smpdb.ca/view/SMP0125537
    Metabolic

    Benzoic acid is present in many fruits, such as apricots, prunes, and berries; many vegetables such as mushrooms (fungus), snap peas, cucumbers, and radishes; spices such as cinnamon, cloves, and allspice … ; nuts such as​ cashews, almonds, pistachios; and dairy products such as yogurt, milk, and cheese.

    Drugs: ATP · Calcium · Mesoheme · Benzoic acid · Pyrophosphoric acid
  3. Pathway

    Metabolism and Physiological Effects of p-Cresol sulphate

    smpdb.ca/view/SMP0126850
    Metabolic

    It has also been linked to cardiovascular disease and oxidative injury. … It has been identified as a uremic toxin according to the European Uremic Toxin Working Group.

    Drugs: Pyridoxal phosphate · Tyrosine · Glutamic acid · P-Cresol · Oxogluric acid · 4-Hydroxyphenylpyruvic acid
  4. Pathway

    Excitatory Neural Signalling Through 5-HTR 4 and Serotonin

    smpdb.ca/view/SMP0000309
    Signaling

    This receptor is also thought to have roles in anxiety, appetite, GI motility, learning, memory, mood, and respiration. … The 5-HT4 receptor is primarily found in the CNS, GI tract, and PNS.

    Drugs: ATP · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acid
  5. Pathway

    Excitatory Neural Signalling Through 5-HTR 7 and Serotonin

    smpdb.ca/view/SMP0000311
    Signaling

    The 5-HT7 receptor is primarily found in the CNS, GI tract, and blood vessels. It is involved in thermoregulation, circadian rhythm, learning and memory, and sleep. … effectors that lead to a specific cellular response.

    Drugs: ATP · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acid
  6. Pathway

    Metabolism and Physiological Effects of N-Formyl-L-Methionine

    smpdb.ca/view/SMP0126765
    Metabolic

    to inhibit and resolve these responses. fMet-containing oligopeptides and proteins also function in other physiological and pathological responses. fMet is a starting residue in the synthesis of proteins … N-Formyl-L-methionine belongs to the class of organic compounds known as methionine and derivatives.

    Drugs: Adenosine phosphate · Methionine · ATP · N-Acetylmethionine · Pyrophosphoric acid
  7. Pathway

    Metabolism and Physiological Effects of N-Acetyl-1-Methylhistidine

    smpdb.ca/view/SMP0126802
    Metabolic

    N-Acetyl-1-methylhistidine belongs to the class of organic compounds known as histidine and derivatives. … N-Acetyl-1-methylhistidine is an acetylated derivative of 1-methylhistidine and a very strong basic compound (based on its pKa).

    Drugs: Histidine · Ademetionine · 1-Methylhistidine
  8. Pathway

    Excitatory Neural Signalling Through 5-HTR 6 and Serotonin

    smpdb.ca/view/SMP0000312
    Signaling

    The 5-HT6 receptor is primarily expressed in the brain and is involved in glutamatergic and cholinergic neuronal activity. … effectors that lead to a specific cellular response.

    Drugs: ATP · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acid
  9. Pathway

    Metabolism and Physiological Effects of Trimethylamine N-oxide (TMAO)

    smpdb.ca/view/SMP0123192
    Metabolic

    This trimethylamine then enters a liver hepatocyte through portal circulation and gets metabolized by FMO3 to form TMAO. … First choline obtained from choline rich foods such as eggs or meat enter the gut and get metabolized to trimethylamine by gut microbes.

    Drugs: Choline · Flavin adenine dinucleotide
  10. Pathway

    Metabolism and Physiological Effects of N-Acetyl-L-Alanine

    smpdb.ca/view/SMP0126554
    Metabolic

    N-terminal acetylation of proteins is a widespread and highly conserved process in eukaryotes that is involved in protection and stability of proteins. … N-Acetyl-L-alanine is a product of the enzyme known as ribosomal alanine N-acetyltransferase (EC 2.3.1.128) which catalyzes the transfer of the acetyl group of acetyl CoA to proteins bearing an N-terminal

    Drugs: Alanine