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Repaglinide Action Pathway (New)
smpdb.ca/view/SMP0124704Drug actionIn consequence, the increased concentration of calcium results in the stimulation of the calcium-dependent exocytosis of insulin granules. … This results in the depolarization of the beta cell and the opening of the L-type calcium channels.
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Glimepiride Action Pathway
smpdb.ca/view/SMP0124722Drug actionNormally SUR1 closes in response to high glucose concentrations, the membrane potential of the cells becomes less negative, the cell depolarizes, voltage-gated calcium channels open, calcium ions enter … the cell, and the influx of intracellular calcium concentration stimulates the secretion of insulin.
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Chlorpropamide Action Pathway
smpdb.ca/view/SMP0126141Drug actionThis depolarization stimulates calcium ion influx through voltage-sensitive calcium channels, raising intracellular concentrations of calcium ions, which results in the secretion (exocytosis) of insulin
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Glipizide Action Pathway
smpdb.ca/view/SMP0126142Drug actionThis results in the depolarization of the pancreatic beta cell and the opening of the voltage-sensitive calcium channels. … This higher concentration of intracellular calcium ions in beta cells stimulates the secretion (exocytosis) of insulin from the cells. This drug is administered as an extended release oral tablet.
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Dextromethorphan Nicotinic Acetylcholine Antagonism Action Pathway
smpdb.ca/view/SMP0126451Drug actionThey are present in the endoplasmic reticulum of central nervous system neurons, where they regulate calcium and potassium, but the reason for that is not well understood.
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1NGX267 Action Pathway
smpdb.ca/view/SMP0126364Drug actionNGX267 is a muscarinic agonist. It is developed for the treatment of Alzheimer’s disease and has shown the potential to both reduce symptoms and slow disease progression. Due to its mechanism of action, NGX267 may be simultaneously effec...
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit beta-1Isoflurophate Action Pathway (new)
smpdb.ca/view/SMP0126686Drug actionIsoflurophate is a cholinesterase inhibitor used to treat glaucoma, as it acts as a powerful miotic agent constricting the pupil and causing the aqueous fluid to flow out and relieve pressure. It acts by irreversibly binding to acetylcho...
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit beta-1Demecarium Action Pathway (new)
smpdb.ca/view/SMP0126687Drug actionDemecarium is a cholinesterase inhibitor used in the treatment of glaucoma, acting as an indirect parasympathomimetic agent by increasing acetylcholine levels in the synaptic cleft. The mechanism of action is demecarium the drug acts on ...
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit beta-1Rivastigmine Action Pathway (new)
smpdb.ca/view/SMP0126688Drug actionRivastigmine is a cholinesterase inhibitor used in the treatment of symptoms of dementia in Alzheimer's and Parkinson's. The drug reversible binds to and inhibits acetylcholinesterase and cholinesterase which stops the breakdown of acety...
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit beta-1Echothiophate Action Pathway
smpdb.ca/view/SMP0126704Drug actionEchothiophate also known as phospholine iodide is an acetylcholinesterase inhibitor, used in the treatment of glaucoma in order to increase the drainage of intraocular fluid. It is administered via eye drops and acts on acetylcholinester...
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit beta-1