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Rotigotine Dopamine Agonist Action Pathway
smpdb.ca/view/SMP0126641Drug actionRotigotine is an agonist at all 5 dopamine receptor subtypes (D1-D5) but binds to the D3 receptor with the highest affinity.
Enzymes: Aromatic-L-amino-acid decarboxylase, D(2) dopamine receptorLisuride Dopamine Agonist Action Pathway
smpdb.ca/view/SMP0126654Drug actionIt may also act as an antagonist at dopamine D1 receptors, and as an agonist at some serotonin receptors (serotonin agonists). … Lisuride is an anti-Parkinson drug chemically related to the dopaminergic ergoline Parkinson's drugs. Lisuride binds to the 5-HT(1A) and 5-HT(2A/2C) receptors.
Enzymes: Aromatic-L-amino-acid decarboxylase, D(2) dopamine receptorPentose Phosphate Pathway
smpdb.ca/view/SMP0000031MetabolicThe pentose phosphate pathway is also involved in the digestive process as the products of nucleic acid catabolism can be metabolized through the pathway (pentose sugars are usually yielded in the breakdown … Reactions 1-3 form the oxidative phase and generate NADPH and pentose 5-phosphate.
Drugs: Adenosine phosphate · ATP · Magnesium cation · Iron · 5-O-phosphono-alpha-D-ribofuranosyl diphosphate · D-glyceraldehyde 3-phosphate +4 moreThioridazine Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126559Drug actionThioridazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; blocks alpha-adrenergic effect, depresses the release of hypothalamic and hypophyseal hormones and is believed … Thioridazine is a substrate of the hepatic enzyme CYP450 2D6 and is also an inhibitor of the same enzyme.
Enzymes: Aromatic-L-amino-acid decarboxylase, D(2) dopamine receptorLumateperone Dopamine Action Action Pathway
smpdb.ca/view/SMP0126694Drug actionAt low dosages, lumateperone's effects are mainly sedative and anti-aggressive. … Both reduced receptor occupancy and its dual action at D2 receptors are thought to contribute to lumateperone's low incidence of extrapyramidal side effects, such as tardive dyskinesia and parkinsonian-like
Enzymes: Aromatic-L-amino-acid decarboxylase, D(2) dopamine receptorMethamphetamine Dopamine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0125231Drug actionMethamphetamine (metamfetamine) is a psychostimulant and sympathomimetic drug. It is mainly taken recreationally but can be taken for ADHD and exogenous obesity in the form of a drug called Desoxyn. … Methamphetamine induces effects of euphoria and affects heart rate, body temperature, blood pressure, appetite, attention, mood, and responses associated with alertness or alarm conditions.
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Tyrosine · Tryptophan · Sapropterin +9 moreEnzymes: Aromatic-L-amino-acid decarboxylase, D(4) dopamine receptorTransaldolase Deficiency
smpdb.ca/view/SMP0000520DiseaseTransaldolase is an enzyme that reversibly converts D-erythrose 4-phosphate and fructose 6-phosphate to D-sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate, as a part of the pentose phosphate … Other signs include abnormal concentrations of polyols in urine and plasma, as well as ribose-, xylulose-, and ribulose-5-phosphate being elevated in urine.
Drugs: Adenosine phosphate · ATP · Magnesium cation · Iron · 5-O-phosphono-alpha-D-ribofuranosyl diphosphate · D-glyceraldehyde 3-phosphate +4 moreGalactosemia II (GALK)
smpdb.ca/view/SMP0000495DiseaseGalactokinase uses 1 ATP to catalyse the phosphorylation of α-D-galactose to galactose 1-phosphate and catalyses β-D-galactose to glucose 1-phosphate. … Treatment includes immediately removing lactose from patient’s diet, however symptoms such as delayed speech, cognitive learning and motor skills can still be present.
Enzymes: UDP-glucuronic acid decarboxylase 1Galactosemia II (GALK)
smpdb.ca/view/SMP0125606DiseaseGalactokinase uses 1 ATP to catalyse the phosphorylation of α-D-galactose to galactose 1-phosphate and catalyses β-D-galactose to glucose 1-phosphate. … Treatment includes immediately removing lactose from patient’s diet, however symptoms such as delayed speech, cognitive learning and motor skills can still be present.
Enzymes: UDP-glucuronic acid decarboxylase 1Transaldolase Deficiency
smpdb.ca/view/SMP0125655DiseaseTransaldolase is an enzyme that reversibly converts D-erythrose 4-phosphate and fructose 6-phosphate to D-sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate, as a part of the pentose phosphate … Other signs include abnormal concentrations of polyols in urine and plasma, as well as ribose-, xylulose-, and ribulose-5-phosphate being elevated in urine.
Drugs: Adenosine phosphate · ATP · Magnesium cation · Iron · 5-O-phosphono-alpha-D-ribofuranosyl diphosphate · D-glyceraldehyde 3-phosphate +4 more