Search
Tranexamic Acid Action Pathway
smpdb.ca/view/SMP0000287Drug actionTranexamic acid is a synthetic version of an amino acid found in the body called lysine that plays a role in antifibrinolytic processes. It is used to stop bleeding and hemorrhaging in patients. Tranexamic acid works by inhibiting the ac...
Alprenolol Action Pathway
smpdb.ca/view/SMP0000297Drug actionAlprenolol (also known as alfeprol, alpheprol or alprenololum) a beta blocker (non-selective) that block beta-1 adrenergic receptor in heart. Blocking beta-1 adrenergic receptor could prevent the binding of epinephrine and norepinephrine...
Betaxolol Action Pathway
smpdb.ca/view/SMP0000299Drug actionBetaxolol (also known as Betoptic or Lokren) is a selective beta blocker that can block beta1-adrenergic receptors and beta2-adrenergic receptors. Blocking of beta1-adrenergic receptors in heart and vascular smooth muscle can lead to red...
Esmolol Action Pathway
smpdb.ca/view/SMP0000301Drug actionEsmolol, sold as Brevibloc, is a cardioselective beta-1 receptor blocker drug. As a beta-blocker, esmolol blocks the agonistic effect of the sympathetic neurotransmitters by competing for receptor binding sites, and as it is cardioselect...
Nadolol Action Pathway
smpdb.ca/view/SMP0000303Drug actionNadolol (also known as Corgard or Solgol) is a beta blocker (non-selective) that are used for treat high blood pressure or chest pain. Nadolol bind to beta1-adrenergic receptors in heart and vascular smooth muscle to block the binding of...
Oxprenolol Action Pathway
smpdb.ca/view/SMP0000304Drug actionOxprenolol (also known as Trasacor or Trasicor) is a beta blocker (non-selective) that are used for treat high blood pressure or chest pain. Oxprenolol bind to beta1-adrenergic receptors in heart and vascular smooth muscle to block the b...
Propranolol Action Pathway
smpdb.ca/view/SMP0000307Drug actionPropranolol, a non-cardioselective beta blocker, inhibits sympathetic stimulation by competing with neurotransmitters like catecholamines to bind beta(1)-adrenergic receptors of the heart and vascular smooth muscle. Propranolol binding r...
Familial Hypercholanemia (FHCA)
smpdb.ca/view/SMP0000317DiseaseFamilial Hypercholanemia can be caused by mutations in the TJP2, BAAT or EPHX1 genes which code for bile acid-CoA:amino acid N-acyltransferase, which plays a part in the metabolism of in bile acids. This enzyme plays a particularly impor...
Lysosomal Acid Lipase Deficiency (Wolman Disease)
smpdb.ca/view/SMP0000319DiseaseLysosomal Acid Lipase Deficiency, also known as Wolman disease, is predictably enough the result of a specific defect in lysosomal acid lipase. The defect results from a mutation on the 10th chromosome to the LIPA gene. Of interest is th...
Drugs: Cholecalciferol · ATP · Magnesium cation · Iron · Dimethylallyl Diphosphate · Formic acid +8 moreIntracellular Signalling Through Adenosine Receptor A2a and Adenosine
smpdb.ca/view/SMP0000320SignalingThe A2A receptor is responsible for regulating myocardial blood flow by vasodilating the coronary arteries, which increases blood flow to the myocardium, but may lead to hypotension. The A2A receptor is also expressed in the brain, where...
Drugs: ATP · Adenosine · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Pyrophosphoric acid