Search
Treprostinil Action Pathway
smpdb.ca/view/SMP0126517Drug actionTreprostinil is a stable tricyclic analogue of prostacyclin, it promotes vasodilation and inhibition of platelet aggregation. Treprostinil is administered either subcutaneously, orally or through inhalation used to treat pulmonary arteri...
Drugs: Treprostinil · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphateEnzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Lysophosphatidic Acid LPA3 Signalling
smpdb.ca/view/SMP0063755SignalingLysophosphatidic acid (LPA) is a water-soluble phospholipid derivative and a potent signalling molecule that binds to six known lysophosphatidic acid receptors (LPARs), named LPA1-LPA6. All six receptors belong to the G protein-coupled r...
Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLasMethylphenobarbital
go.drugbank.com/drugs/DB00849ApprovedA barbiturate that is metabolized to phenobarbital. It has been used for similar purposes, especially in epilepsy, but there is no evidence mephobarbital offers any advantage over phenobarbital.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersSynonyms: 5-ethyl-1-methyl-5-phenylbarbituric acid, 5-Ethyl-1-methyl-5-phenyl-pyrimidine-2,4,6-trioneThiamylal
go.drugbank.com/drugs/DB01154ApprovedVet approvedA barbiturate that is administered intravenously for the production of complete anesthesia of short duration, for the induction of general anesthesia, or for inducing a hypnotic state.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersSynonyms: 5-Allyl-5-(1-methylbutyl)-2-thiobarbituric acid, dihydro-5-(1-methylbutyl)-5-(2-propenyl)-2-thioxo-4,6(1H,5H)-pyrimidinedioneEtomidate
go.drugbank.com/drugs/DB00292ApprovedInvestigationalIt has been proposed as an induction anesthetic.
Categories: Adrenergic alpha-2 Receptor Agonists, Heterocyclic Compounds, 1-RingSynonyms: (R)-(+)-1-(α-methylbenzyl)imidazole-5-carboxylic acid ethyl ester, (+)-ethyl 1-(α-methylbenzyl)imidazole-5-carboxylateSelexipag Action Pathway
smpdb.ca/view/SMP0126508Drug actionSelexipag is a non-prostanoid prostacyclin receptor agonist, also known as Uptravi typically used to treat pulmonary arterial hypertension. Selexipag is a selective prostacyclin receptor agonist, it is administered orally and is metaboli...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Hydroxypropyl cellulose
go.drugbank.com/drugs/DB00840ApprovedAs a food additive, hydroxypropyl cellulose is used as a thickener and as an emulsion stabilizer. … , and as a lubricant for artificial eyes.
Synonyms: Cellulose, 2-hydroxypropyl ether, Hydroxypropyl cellulose (type H)International brands: A-GelDiclofenamide
go.drugbank.com/drugs/DB01144ApprovedA carbonic anhydrase inhibitor that is used in the treatment of glaucoma.
Synonyms: 4,5-dichloro-m-benzenedisulfonamide, 3,4-dichloro-5-sulfamylbenzenesulfonamideDopamine
go.drugbank.com/drugs/DB00988ApprovedInvestigationalIt is derived from tyrosine and is the precursor to norepinephrine and epinephrine. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. … A family of receptors (receptors, dopamine) mediate its action.
Synonyms: 4-(2-aminoethyl)catechol, 4-(2-aminoethyl)pyrocatecholMixtures: Dopamine HCl 3.2mg/ml Dextrose 5% Inj USP, Dopamine HCl 1.6mg/ml Dextrose 5% Inj USPSelenoamino Acid Metabolism
smpdb.ca/view/SMP0000029MetabolicPhospholipids are membrane components in P. aeruginosa. The major phospholipids of P. aeruginosa are phosphatidylethanolamine, phosphatidylglycerol, and cardiolipin. All phospholipids contain sn-glycerol-3-phosphate esterified with fatty...
Enzymes: S-adenosylmethionine synthase isoform type-2