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Pralatrexate
go.drugbank.com/drugs/DB06813ApprovedInvestigational[A246693] Pralatrexate is designed to have a higher affinity for the reduced folate carrier, a protein that is overexpressed in malignant cells and is upregulated by oncogenes. … Pralatrexate is an antifolate for the treatment of relapsed or refractory peripheral T-cell lymphoma [L37674].
Categories: Antineoplastic and Immunomodulating AgentsSynonyms: (2S)-2-((4-((1RS)-1-((2,4-Diaminopteridin-6-yl)methyl)but-3-ynyl)benzoyl)amino)pentanedioic acid, N-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-L-glutamic acidLanreotide
go.drugbank.com/drugs/DB06791ApprovedInvestigationalIt is approved in several countries worldwide, including the United Kingdom, Australia, and Canada. Lanreotide was first approved for use in the United States by the FDA on August 30, 2007. … Lanreotide is manufactured by the company, _Ipsen Pharmaceuticals_ as lanreotide acetate, and marketed as _Somatuline_.
Categories: Pituitary and Hypothalamic Hormones and Analogues, Sex Hormones and InsulinsProducts: Somatuline Autogel 120mg, prolonged-release solution for injection in a pre-filled syringe, Somatuline Autogel 60mg, prolonged-release solution for injection in a pre-filled syringeLemborexant
go.drugbank.com/drugs/DB11951ApprovedInvestigational[L10863] Recent research in the field of sleep disorders has revealed that insomnia is likely driven not by the inability of the brain to "switch on" sleep-related circuits, but rather an inability to … Lemborexant is a novel dual orexin receptor antagonist used in the treatment of insomnia characterized by difficulties with sleep onset and/or sleep maintenance.
Categories: Hypnotics and Sedatives, Sleep Initiation and Maintenance DisordersProducts: DAYVIGO FILM-COATED TABLET 10MG, Dayvigo 10mg Film coated tabletTrimetrexate
go.drugbank.com/drugs/DB01157ApprovedIt is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against pneumocystis pneumonia in AIDS patients. Myelosuppression is its dose-limiting toxic effect.
Categories: Antiparasitic Products, Insecticides and RepellentsProducts: Neutrexin Pws IV 25mg/vialAlpha Linolenic Acid and Linoleic Acid Metabolism
smpdb.ca/view/SMP0000018MetabolicBoth LNA and ALA are essential dietary requirements for all mammals since they cannot be synthesized natively in the body. … LNA enters the cell and is catalyzed to gamma-linolenic acid (GLA) by acyl-CoA 6-desaturase (delta-6-desaturase/fatty acid desaturase 2).
Metabolism and Physiological Effects of Quinolinic Acid
smpdb.ca/view/SMP0123249MetabolicWhen this compound enters into systemic circulation it is shown to be a major uremic toxin when high levels of it are retained in the blood and not excreted in urine. … Quinolinic acid is an indole uremic toxin compound that is formed through metabolism from dietary tryptophan in liver hepatic cells.
Drugs: Tryptophan · Quinolinic Acid · Kynurenine · Mesoheme · Flavin adenine dinucleotide · 3-hydroxyanthranilic acid +1 moreEnzymes: Neutral and basic amino acid transport protein rBATMetabolism and Physiological Effects of Uric acid
smpdb.ca/view/SMP0124845MetabolicPurines can be made endogenously in the body or can be obtained exogenously from foods such as red meat. The purines are guanine and adenine. These undergo metabolism in the liver to form uric acid. … Uric acid can enter the blood and produce toxic effects on the cardiovascular, renal and joints, leading to cardiovascular disease, kidney disease and arthritis/ gout.
Metabolism and Physiological Effects of Oxalic acid
smpdb.ca/view/SMP0124875MetabolicThe oxalate formed in the liver form these 3 sources can enter the blood and have toxic effects in other tissues. Oxalate can promote cardiovascular disease, neurotoxicity and inflammation. … It is produced in the body by metabolism of glyoxylic acid or ascorbic acid. Glyoxylate is generated through glycine and hydroxyproline catabolism and can be converted to oxalate.
Drugs: Pyridoxal phosphate · Ascorbic acid · Succinic acid · Glutamic acid · Glycine · Proline +4 moreEnzymes: Sodium- and chloride-dependent transporter XTRP3, Sodium- and chloride-dependent creatine transporter 1Metabolsim and Physiological Effects of Argininic acid
smpdb.ca/view/SMP0125504MetabolicIn a healthy individual arginine would then continue in the urea cycle to synthesize urea and ornithine, however, due to the deficiency in arginase, arginine is accumulates in the liver, causing hyperargininemia … Argininic acid is an uremic toxin produced in people with hyperargininemia. Hyperargininemia is an inborn problem in the urea cycle caused by a deficiency in liver arginase.
Drugs: Pyridoxal phosphate · Arginine · Aspartic acid · Ornithine · L-Glutamine · Adenosine phosphate +10 moreMetabolism and Physiological Effects of 3-Deoxyglucosone
smpdb.ca/view/SMP0125516MetabolicIt normally is synthesized and accumulates with high serum glucose due to diabetes. 3-deoxyglucosone causes cell apoptosis and neurotoxicity. … It is unknown why 3-deoxyglucosone is synthesized in uremia patients, since it is not present in the urine of healthy people.