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Displaying results 1 - 10 of 125 in total
  1. Pathway

    Salicylate-Sodium Action Pathway

    smpdb.ca/view/SMP0000708
    Drug action

    Salicylate-sodium can block prostaglandin synthesis by the action of inhibition of prostaglandin G/H synthase 1 and 2. … Salicylate-sodium (also named salsonin or clin) is a nonsteroidal anti-inflammatory drug (NSAID). It can be used for relieving pain and reducing fever.

    Drugs: Glutamic acid · Glutathione · Dinoprostone · Calcium · Magnesium cation · Salicylic acid +5 more
  2. Pathway

    Lidocaine Sodium Channel Cardiac Muscle Relaxation Action Pathway

    smpdb.ca/view/SMP0126504
    Drug action

    It ultimately elicits its numbing activity by blocking sodium channels so that the neurons of local tissues that have the medication applied on are transiently incapable of signaling the brain regarding … , conduction rate, and force of contraction.

    Drugs: Lidocaine · Potassium cation · Calcium · Cyclic adenosine monophosphate
    Enzymes: Sodium channel subunit beta-1, Sodium channel protein type 5 subunit alpha
  3. Pathway

    Neuron Function

    smpdb.ca/view/SMP0000224
    Physiological

    Neurons maintain a voltage gradient across their membrane using metabolically driven ion pumps and ion channels for charge-carrying ions, including sodium (Na+), potassium (K+), chloride (Cl−), and calcium … Once the interior of the neuron becomes more positively charged, the sodium channels close and the potassium channels open to allow potassium to move out of the cell to try and restore the resting membrane

    Drugs: ATP · Norepinephrine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter
  4. Pathway

    Bupivacaine Action Pathway

    smpdb.ca/view/SMP0000393
    Drug action

    Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Bupivacaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Bupivacaine diffuses across the neuronal plasma membrane in its uncharged base form.

    Drugs: ATP · Bupivacaine · Norepinephrine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter
  5. Pathway

    Chloroprocaine Action Pathway

    smpdb.ca/view/SMP0000394
    Drug action

    Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Chloroprocaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons.

    Drugs: ATP · Norepinephrine · Dopamine · Chloroprocaine · Potassium cation · Calcium
    Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter
  6. Pathway

    Proparacaine Action Pathway

    smpdb.ca/view/SMP0000403
    Drug action

    Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Proparacaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Proparacaine diffuses across the neuronal plasma membrane in its uncharged base form.

    Drugs: ATP · Norepinephrine · Proparacaine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter
  7. Pathway

    Imipramine

    smpdb.ca/view/SMP0000422
    Drug action

    It does so by competing for the same binding site as norepinephrine on the sodium-dependent noradraneline transporter (SLC6A2) and by competing with serotonin for binding to the sodium-dependent serotonin … Desipramine is an active metabolite and also has similar actions to imipramine on norepinephrine and serotonin reuptake.

    Drugs: NADH · ATP · Norepinephrine · Imipramine · Dopamine · Desipramine +4 more
    Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter
  8. Pathway

    Cocaine Action Pathway

    smpdb.ca/view/SMP0000395
    Drug action

    Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Cocaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Cocaine diffuses across the neuronal plasma membrane in its uncharged base form.

    Drugs: ATP · Norepinephrine · Cocaine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter
  9. Pathway

    Dibucaine Action Pathway

    smpdb.ca/view/SMP0000396
    Drug action

    Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Dibucaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Dibucaine diffuses across the neuronal plasma membrane in its uncharged base form.

    Drugs: ATP · Norepinephrine · Cinchocaine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter
  10. Pathway

    Levobupivacaine Action Pathway

    smpdb.ca/view/SMP0000397
    Drug action

    Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Levobupivacaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons.

    Drugs: ATP · Norepinephrine · Dopamine · Levobupivacaine · Potassium cation · Calcium
    Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter