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Cholecalciferol Vitamin D Action Pathway
smpdb.ca/view/SMP0125002Drug actionVitamin D3 (Cholecalciferol) is a form of Vitamin D used in the treatment of specific medical conditions such as refractory rickets, hypoparathyroidism, and familial hypophosphatemia, as well as osteoporosis … Calcitriol interacts with vitamin D receptors in the small intestine to enhance the efficiency of intestinal calcium and phosphorous absorption from about 10-15% to 30-40% and 60% increased to 80%, respectively
Enzymes: Vitamin D 25-hydroxylase, Vitamin D3 receptor2-Hydroxyglutric Aciduria (D and L Form)
smpdb.ca/view/SMP0000136DiseaseA deficiency in this enzyme results in accumulation of D-2-Hydroxyglutaric acid in plasma, spinal fluid, and urine; oxoglutaric acid in urine; and gabba-aminobutyric acid in spinal fluid. … A deficiency in this enzyme results in accumulation of L-2-Hydroxyglutaric acid in plasma, spinal fluid, and urine; and L-lysine in plasma and spinal fluid.
Drugs: Pyridoxal phosphate · Pyruvic acid · Biotin · Aspartic acid · L-Glutamine · Adenosine phosphate +17 moreEnzymes: N-acetyl-D-glucosamine kinaseAlpha Linolenic Acid and Linoleic Acid Metabolism
smpdb.ca/view/SMP0000018MetabolicLNA enters the cell and is catalyzed to gamma-linolenic acid (GLA) by acyl-CoA 6-desaturase (delta-6-desaturase/fatty acid desaturase 2). … Both LNA and ALA are essential dietary requirements for all mammals since they cannot be synthesized natively in the body.
Enzymes: Fatty acid desaturase 1, Fatty acid desaturase 2Metabolism and Physiological Effects of Oxalic acid
smpdb.ca/view/SMP0124875MetabolicGlycine and hydroxyproline comes from protein sources in the diet such as red meat and eggs. Glycine Is converted into glyoxylate in the peroxisome by the enzyme d-amino acid oxidase. … Glyoxylate is generated through glycine and hydroxyproline catabolism and can be converted to oxalate. In humans, this process takes place in the liver.
Drugs: Pyridoxal phosphate · Ascorbic acid · Succinic acid · Glutamic acid · Glycine · Proline +4 moreEnzymes: D-amino-acid oxidase, Sodium- and chloride-dependent transporter XTRP3Metabolsim and Physiological Effects of Argininic acid
smpdb.ca/view/SMP0125504MetabolicArginnosuccinate is synthesized from citrulline and aspartic acid by the enzyme argininosuccinate synthase. That is catalyzed by argininosuccinate lyase to produce arginine and fumaric acid. … Glutamic acid is carboxylated into 1-Pyrroline-5-carboxylic acid by the enzyme Delta-1-pyrroline-5-carboxylate synthase. 1-Pyrroline-5-carboxylic acid with glutaric acid synthesize Oxoglutaric acid and
Drugs: Pyridoxal phosphate · Arginine · Aspartic acid · Ornithine · L-Glutamine · Adenosine phosphate +10 moreEnzymes: D-amino-acid oxidase, Neutral amino acid transporter AMetabolism and Physiological Effects of 4-Hydroxyhippuric Acid
smpdb.ca/view/SMP0125537Metabolic4-Hydroxyhippuric, also known as 4-hydroxybenzoylglycine or 4-hydroxyhippate acid, is a metabolite of hippuric acid, and a uremic toxin. … Benzoic acid is present in many fruits, such as apricots, prunes, and berries; many vegetables such as mushrooms (fungus), snap peas, cucumbers, and radishes; spices such as cinnamon, cloves, and allspice
Vitamin A Deficiency
smpdb.ca/view/SMP0000336DiseaseA defect in this enzyme results in decrease of levels of retinal and vitamin A in serum; Signs and symptoms include night blindness, poor adaptation to darkness, dry skin and hair. … Vitamin A deficiency can be caused by many causes. A defect in the BCMO1 gene which codes for beta,beta-carotene 15,15’-monooxygenase is one of them.
Vitamin B6 Metabolism
smpdb.ca/view/SMP0000017MetabolicPLP serves as cofactor in a variety of reactions including from amino acid metabolism, (in particular in reactions such as transamination, deamination, and decarboxylation). … There are a wide variety of biproducts from the metabolism in question, most of which find there ways into the urine and from there are excreted. One such biproduct is 4-pyridoxic acid.
Drugs: Pyridoxal phosphate · Pyridoxal · Pyridoxine · Magnesium cation · Zinc · Pyridoxamine-5'-Phosphate +3 moreVitamin A Deficiency
smpdb.ca/view/SMP0125788DiseaseA defect in this enzyme results in decrease of levels of retinal and vitamin A in serum; Signs and symptoms include night blindness, poor adaptation to darkness, dry skin and hair. … Vitamin A deficiency can be caused by many causes. A defect in the BCMO1 gene which codes for beta,beta-carotene 15,15’-monooxygenase is one of them.
The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria
smpdb.ca/view/SMP0002359Diseasedehydrogenase (D2HGDH) converts D-2-hydroxyglutarate (D-2HG) to α-ketoglutaric acid. … D-2-Hydroxyglutarate is an oncometabolite produced from IDH mutations. A mutation in IDH causes high concentrations of D-2-Hydroxyglutaric acid.
Enzymes: D-2-hydroxyglutarate dehydrogenase, mitochondrial