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Mycophenolate mofetil

go.drugbank.com/drugs/DB00688
ApprovedInvestigational

Mycophenolate mofetil, also known as MMF or CellCept, is a prodrug of mycophenolic acid, and classified as a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). This drug is an immunosuppressant combined with drugs such as Cyclosporine and corticosteroids to prevent organ rejection after hepatic, re...

  1. Drug

    Mycophenolic acid

    go.drugbank.com/drugs/DB01024
    ApprovedInvestigational

    [A249190] [Mycophenolate mofetil], a prodrug of mycophenolic acid, is also prescribed to transplant recipients to prevent organ rejection.[L42020]

    Synonyms: MycophenolateSalts: Mycophenolate sodium
  2. Pathway

    Mycophenolate mofetil Predicted Metabolism Pathway

    smpdb.ca/view/SMP0174878
    Metabolic

    Metabolites of Mycophenolate mofetil are predicted with biotransformer.

    Drugs: Mycophenolate mofetil · Mesoheme
  3. Pathway

    Mycophenolic Acid Metabolism Pathway (old)

    smpdb.ca/view/SMP0000652
    Drug metabolism

    It is available as a prodrug, Mycophenolate mofetil (MMF), which is a 2-morpholinoethyl ester with improved bioavailability.

    Drugs: NADH · ATP · Mycophenolate mofetil · Mycophenolic acid · Potassium cation · Mesoheme +2 more
  4. Indication

    Transplanted Organ Rejection

    go.drugbank.com/conditions/DBCOND0120716
    Drugs: Mycophenolate mofetil · Prednisolone · Prednisolone acetate · Sirolimus
  5. Drug

    Voclosporin

    go.drugbank.com/drugs/DB11693
    ApprovedInvestigational

    [L31253] In July 2022, the EMA's Committee for Medicinal Products for Human Use (CHMP) recommended voclosporin be granted marketing authorization for use in combination with [mycophenolate mofetil]

  6. Indication

    Kidney Transplant Rejection

    go.drugbank.com/conditions/DBCOND0066662
    Drugs: Alemtuzumab · Antilymphocyte immunoglobulin (horse) · Azathioprine · Belatacept · Cyclosporine · Everolimus +2 more
  7. Pathway

    Mycophenolic Acid Action Pathway

    smpdb.ca/view/SMP0122722
    Drug action

    Mycophenolic acid is an immunosuppressant drug and anti-proliferative drug derived from Penicillium stoloniferum. It inhibits the purine de novo synthesis for purine nucleotides through inhibiting the enzyme inosine 5'-monophosphate dehy...

    Drugs: Tetrahydrofolic acid · Aspartic acid · L-Glutamine · Adenosine phosphate · Glutamic acid · Glycine +14 more
  8. Pathway

    Mycophenolic acid Predicted Metabolism Pathway

    smpdb.ca/view/SMP0174716
    Metabolic

    Metabolites of Mycophenolic acid are predicted with biotransformer.

    Drugs: Mycophenolic acid · Mesoheme