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Warfarin Action Pathway
smpdb.ca/view/SMP0000268Drug actionWarfarin is a drug part of the anticoagulant drug class, used to dissolve or break down blood clots. Warfarin inhibits vitamin K epoxide reductase complex subunit 1. … vitamin K epoxide reductase complex subunit 1 to become reduced vitamin K (phylloquinone), and then back to vitamin K1 2,3-epoxide continually through vitamin K-dependent gamma-carboxylase, but as warfarin
Warfarin Action Pathway (New)
smpdb.ca/view/SMP0124982Drug actionWarfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. … Warfarin is a [vitamin K] antagonist which acts to inhibit the production of vitamin K by inhibiting vitamin K epoxide reductase.
Monoamine Oxidase-A Deficiency (MAO-A)
smpdb.ca/view/SMP0125595DiseaseThe buildup of chemicals may also damage the brain, leading to a lower IQ in individuals with this disorder. … MAO-A is an enzyme that catalyzes the deamination of amines such as epinephrine, dopamine and tyramine, as part of the tyrosine metabolism pathway.
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 moreSphingolipid Signaling (Receptor)
smpdb.ca/view/SMP0524344SignalingThrough these receptor‑specific G protein couplings—spanning cAMP suppression, Ca²⁺ mobilization, PKC activation, Rho GTPase–driven cytoskeletal remodeling, and PI3K/Akt and MAPK pathways—S1P orchestrates
Enzymes: Sphingosine 1-phosphate receptor 2, Sphingosine 1-phosphate receptor 4Monoamine Oxidase-A Deficiency (MAO-A)
smpdb.ca/view/SMP0000533DiseaseThe buildup of chemicals may also damage the brain, leading to a lower IQ in individuals with this disorder. … MAO-A is an enzyme that catalyzes the deamination of amines such as epinephrine, dopamine and tyramine, as part of the tyrosine metabolism pathway.
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Aspartic acid · Tyrosine · Glutamic acid +20 moreHistamine H1 Receptor Activation
smpdb.ca/view/SMP0063452SignalingAmong many other functions, PKC activates NF-κB. This leads to increased antigen presentation and increased expression of pro-inflammatory cytokines, cell adhesion molecules, and chemotactic factors. … This results in the dissociation of a Gαq-GTP monomer and a Gβγ dimer from the receptor .
Drugs: CalciumEnzymes: Histamine H1 receptor, Inositol 1,4,5-trisphosphate receptor type 1Minaprine Serotonin receptor Antidepressant Action Pathway
smpdb.ca/view/SMP0126747Drug actionMAO A inhibition is thought to be more relevant to antidepressant activity than the inhibition caused by MAO B. Selective MAO B inhibitors have no antidepressant effects. … Minaprine acts on many targets in the neurons. Firstly, this drug binds as an antagonist to the serotonin type 2 receptors (C, B, and C).
Enzymes: 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 2CIntracellular Signalling Through Prostacyclin Receptor and Prostacyclin
smpdb.ca/view/SMP0000354SignalingThe receptor is a G-protein coupled receptor, upon its binding it activates G proteins causing the activation of adenylyl cyclase and production of cAMP messenger molecules. cAMP activates PKA (protein … Prostacyclin binding to its receptor increases vasodilation and decreases platelet aggregation.
Enzymes: Prostacyclin receptorTrimebutine M3 Receptor Intestine Relaxation Action Pathway
smpdb.ca/view/SMP0126338Drug actionPossible side effects of using trimebutine may include dry mouth, heartburn, nausea, and drowsiness.
Drugs: ATP · Nitric Oxide · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate +3 moreEnzymes: Mu-type opioid receptor, Muscarinic acetylcholine receptor M3Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
smpdb.ca/view/SMP0000321SignalingThe adenosine receptor A2b activates G(s) proteins which lead to the activation of adenylyl cyclase which produces the secondary messenger cAMP. cAMP activates PKA (protein kinase A) which phosphorylates
Drugs: ATP · Adenosine · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Pyrophosphoric acidEnzymes: Adenosine receptor A2b