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Estradiol acetate Predicted Metabolism Pathway
smpdb.ca/view/SMP0174628MetabolicMetabolites of Estradiol acetate are predicted with biotransformer.
Estradiol benzoate Predicted Metabolism Pathway
smpdb.ca/view/SMP0174629MetabolicMetabolites of Estradiol benzoate are predicted with biotransformer.
Estriol Predicted Metabolism Pathway
smpdb.ca/view/SMP0174855MetabolicMetabolites of Estriol are predicted with biotransformer.
Tamoxifen Anti-Cancer Action Pathway
smpdb.ca/view/SMP0124698Drug actionIt competitively inhibits estrogen/estradiol binding to its receptor which prevents the coactivator from binding to the receptor-tamoxifen complex in the nucleus. … Tamoxifen is an anticancer drug that is a selective estrogen receptor modulator also known as a non-steroidal anti-estrogen.
Drugs: Tamoxifen · Estradiol · Mesoheme · Flavin adenine dinucleotide · Uridine-5'-Diphosphate · FormaldehydeEnzymes: Steroid hormone receptor ERR1Sphingolipid Signaling (Receptor)
smpdb.ca/view/SMP0524344SignalingThrough these receptor‑specific G protein couplings—spanning cAMP suppression, Ca²⁺ mobilization, PKC activation, Rho GTPase–driven cytoskeletal remodeling, and PI3K/Akt and MAPK pathways—S1P orchestrates
Enzymes: Sphingosine 1-phosphate receptor 2, Sphingosine 1-phosphate receptor 4Estrone Metabolism
smpdb.ca/view/SMP0030880MetabolicEstrone can also be reversibly converted into estradiol by estradiol 17-beta-dehydrogenase 1. … This same enzyme can reversibly convert 16a-hydroxyestrone (synthesized from estrone via cytochrome P450 3A5) into estriol. Estriol is alternatively synthesized from estradiol via cytochrome P450 3A5.
Enzymes: Estradiol 17-beta-dehydrogenase 1Histamine H1 Receptor Activation
smpdb.ca/view/SMP0063452SignalingThis results in the dissociation of a Gαq-GTP monomer and a Gβγ dimer from the receptor . … Upon binding by histamine, the H1 receptor allosterically activates the G-protein by exchanging GDP for GTP at the G-protein's alpha subunit (Gαq).
Drugs: CalciumEnzymes: Histamine H1 receptor, Inositol 1,4,5-trisphosphate receptor type 1Minaprine Serotonin receptor Antidepressant Action Pathway
smpdb.ca/view/SMP0126747Drug actionMinaprine is an amino-phenylpyridazine antidepressant. It is indicated in the treatment of various depressive states. Minaprine acts on many targets in the neurons. Firstly, this drug binds as an antagonist to the serotonin type 2 recept...
Enzymes: 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 2CIntracellular Signalling Through Prostacyclin Receptor and Prostacyclin
smpdb.ca/view/SMP0000354SignalingThe receptor is a G-protein coupled receptor, upon its binding it activates G proteins causing the activation of adenylyl cyclase and production of cAMP messenger molecules. cAMP activates PKA (protein … Prostacyclin binding to its receptor increases vasodilation and decreases platelet aggregation.
Enzymes: Prostacyclin receptorTrimebutine M3 Receptor Intestine Relaxation Action Pathway
smpdb.ca/view/SMP0126338Drug actionTrimebutine is a spasmolytic agent used for the symptomatic treatment of irritable bowel syndrome (IBS) and treatment of postoperative paralytic ileus following abdominal surgery. Trimebutine is a spasmolytic agent that regulates intesti...
Drugs: ATP · Nitric oxide · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate +3 moreEnzymes: Mu-type opioid receptor, Muscarinic acetylcholine receptor M3