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Displaying results 1 - 10 of 19 in total
  1. Pathway

    Estradiol acetate Predicted Metabolism Pathway

    smpdb.ca/view/SMP0174628
    Metabolic

    Metabolites of Estradiol acetate are predicted with biotransformer.

    Drugs: Mesoheme · Estradiol acetate
  2. Pathway

    Estradiol benzoate Predicted Metabolism Pathway

    smpdb.ca/view/SMP0174629
    Metabolic

    Metabolites of Estradiol benzoate are predicted with biotransformer.

    Drugs: Mesoheme · Estradiol benzoate
  3. Pathway

    Tamoxifen Anti-Cancer Action Pathway

    smpdb.ca/view/SMP0124698
    Drug action

    It competitively inhibits estrogen/estradiol binding to its receptor which prevents the coactivator from binding to the receptor-tamoxifen complex in the nucleus.

    Drugs: Tamoxifen · Estradiol · Mesoheme · Flavin adenine dinucleotide · Uridine-5'-Diphosphate · Formaldehyde
  4. Pathway

    Estrone Metabolism

    smpdb.ca/view/SMP0030880
    Metabolic

    Estrone can also be reversibly converted into estradiol by estradiol 17-beta-dehydrogenase 1. … Estriol is alternatively synthesized from estradiol via cytochrome P450 3A5.

    Drugs: Ademetionine · NADH · Estrone · Estradiol · Magnesium cation · Mesoheme +3 more
    Enzymes: Estradiol 17-beta-dehydrogenase 1
  5. Pathway

    Aromatase Deficiency

    smpdb.ca/view/SMP0000565
    Disease

    Aromatase deficiency is a rare inborn error of metabolism (IEM) and autosomal recessive disorder of mutations in the CYP19A1 gene. The CYP19A1 gene encodes for the enzyme aromatase. Aromatase converts androgens to estrogens which is vita...

    Drugs: NADH · Testosterone · Estrone · Estradiol · Calcium · Androstenedione +6 more
    Enzymes: Estradiol 17-beta-dehydrogenase 1
  6. Pathway

    17-beta Hydroxysteroid Dehydrogenase III Deficiency

    smpdb.ca/view/SMP0125781
    Disease

    17-beta hydroxysteroid dehydrogenase III deficiency, also known as 17-KSR deficiency or male pseudohermaphroditism with gynecomastia (MPH), is as rare inborn error of metabolism (IEM) and autosomal recessive disorder of the androgen and ...

    Drugs: NADH · Testosterone · Estrone · Estradiol · Calcium · Androstenedione +6 more
    Enzymes: Estradiol 17-beta-dehydrogenase 1
  7. Pathway

    Androgen and Estrogen Metabolism

    smpdb.ca/view/SMP0000068
    Metabolic

    This pathway describes the inactivation and catabolism of male (androgen) and female (estrogen) hormones. Many steroid hormones are transformed by sulfatases, dehydrogenases and glucuronide transferases to enhance their solubility and to...

    Drugs: NADH · Testosterone · Estrone · Estradiol · Calcium · Androstenedione +6 more
    Enzymes: Estradiol 17-beta-dehydrogenase 1
  8. Pathway

    17-beta Hydroxysteroid Dehydrogenase III Deficiency

    smpdb.ca/view/SMP0000356
    Disease

    17-beta hydroxysteroid dehydrogenase III deficiency, also known as 17-KSR deficiency or male pseudohermaphroditism with gynecomastia (MPH), is as rare inborn error of metabolism (IEM) and autosomal recessive disorder of the androgen and ...

    Drugs: NADH · Testosterone · Estrone · Estradiol · Calcium · Androstenedione +6 more
    Enzymes: Estradiol 17-beta-dehydrogenase 1
  9. Pathway

    Aromatase Deficiency

    smpdb.ca/view/SMP0125782
    Disease

    Aromatase deficiency is a rare inborn error of metabolism (IEM) and autosomal recessive disorder of mutations in the CYP19A1 gene. The CYP19A1 gene encodes for the enzyme aromatase. Aromatase converts androgens to estrogens which is vita...

    Drugs: NADH · Testosterone · Estrone · Estradiol · Calcium · Androstenedione +6 more
    Enzymes: Estradiol 17-beta-dehydrogenase 1
  10. Pathway

    Megestrol acetate Action Pathway

    smpdb.ca/view/SMP0126528
    Drug action

    Megestrol acetate is a synthetic progestational hormone initially developed as a contraceptive. Nowadays, it is used as a drug to treat anorexia and cachexia (or unexplained weight loss) and as an antineoplastic agent to treat inoperable...

    Drugs: NADH · ATP · Megestrol acetate · Progesterone · Testosterone · Estrone +9 more
    Enzymes: Estradiol 17-beta-dehydrogenase 1