Search
Indium In-111 oxyquinoline Drug Metabolism
smpdb.ca/view/SMP0130676MetabolicIndium In-111 oxyquinoline passes through the liver and is then excreted from the body mainly through the kidney. … Indium In-111 oxyquinoline is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.
Drugs: Indium In-111 oxyquinolineFatty Acid Elongation in Mitochondria
smpdb.ca/view/SMP0000054MetabolicMitochondrial elongation may result in fatty acids up to C16 in length. Fatty acid elongation in mitochondria is essentially the reverse of beta-oxidation for fatty acid oxidation. … In liver and kidney fatty acid elongation operates best in the presence of both NADH and NADPH, whereas in heart and skeletal muscle, only NADH is required.
Indium In-111 pentetate Drug Metabolism
smpdb.ca/view/SMP0130595MetabolicIndium In-111 pentetate passes through the liver and is then excreted from the body mainly through the kidney. … Indium In-111 pentetate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.
Drugs: Indium In-111 pentetateFc Epsilon Receptor I Signaling in Mast Cells
smpdb.ca/view/SMP0000358SignalingFc epsilon receptor 1 (Fc epsilon RI) is a high-affinity receptor for the Fc region of immunoglobulin E (IgE), an antibody isotope involved in allergies. … The release of these compounds results in the inflammatory response.
Enzymes: Linker for activation of T-cells family member 1The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria
smpdb.ca/view/SMP0002358DiseaseThis results in modulations of HIF-mediated hypoxia responses and alterations in gene expression through global epigenetic remodelling that may contribute to malignant transformation. … L-2-hydroxyglutarate is a competitive inhibitor of 2OG-dependent dioxygenases resulting in genetic changes and malignancies.
Enzymes: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrialThe Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria
smpdb.ca/view/SMP0002359DiseaseThis results in modulations of HIF-mediated hypoxia responses and alterations in gene expression through global epigenetic remodelling that may contribute to malignant transformation. 2-Hydroxyglutarate … A mutation in IDH causes high concentrations of D-2-Hydroxyglutaric acid. D-2-hydroxyglutarate is a competitive inhibitor of 2OG-dependent dioxygenases resulting in genetic changes and malignancies.
Enzymes: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrialHomocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type
smpdb.ca/view/SMP0000570DiseaseThis enzyme is responsible for forming L-methionine and tetrahydrofolic acid from homocysteine and 5-methyltetrahydrofolic acid. … Methionine synthase deficiency is characterized by an increase in homocysteine levels in the body and excreted in the urine, as well as decreased levels of methionine in the blood.
Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Choline · Adenosine phosphate · Serine +17 moreHomocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type
smpdb.ca/view/SMP0125684DiseaseThis enzyme is responsible for forming L-methionine and tetrahydrofolic acid from homocysteine and 5-methyltetrahydrofolic acid. … Methionine synthase deficiency is characterized by an increase in homocysteine levels in the body and excreted in the urine, as well as decreased levels of methionine in the blood.
Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Choline · Adenosine phosphate · Serine +17 moreLong-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (Fatty Acid Elongation in Mitochondria)
smpdb.ca/view/SMP0125748DiseaseThe estimated birth prevalence of LCHADD is 1 in 62 000 in Northern European individuals. The worldwide birth prevalence is estimated at 1 in 250 000. … LCHAD-deficiency individuals are also at risk for breathing difficulties, serious heart problems, coma, and sudden death. Fasting or illnesses (e.g. viral infections) can trigger related problems.
Indocyanine green acid form Drug Metabolism
smpdb.ca/view/SMP0130870MetabolicIndocyanine green acid form passes through the liver and is then excreted from the body mainly through the kidney. … Indocyanine green acid form is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.
Drugs: Indocyanine green acid form