Displaying drugs 251 - 275 of 11681 in total
Valproic acid
Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton. It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a serendipitous discovery was made by George Carraz during his investigations into...
Approved
Investigational
Matched Description: … nearly a century. ... is the subject of many clinical trials in a variety of cancer types. ... [A178051] It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for …
Matched Categories: … UGT1A1 Substrates with a Narrow Therapeutic Index ... UGT1A3 Substrates with a Narrow Therapeutic Index ... UGT1A6 Substrates with a Narrow Therapeutic Index ... UGT1A9 Substrates with a Narrow Therapeutic Index ... UGT2B7 Substrates with a Narrow Therapeutic Index …
Matched Categories: … UGT1A1 Substrates with a Narrow Therapeutic Index ... UGT1A3 Substrates with a Narrow Therapeutic Index ... UGT1A6 Substrates with a Narrow Therapeutic Index ... UGT1A9 Substrates with a Narrow Therapeutic Index ... UGT2B7 Substrates with a Narrow Therapeutic Index …
Atriplex confertifolia pollen
Atriplex confertifolia pollen is the pollen of the Atriplex confertifolia plant. Atriplex confertifolia pollen is mainly used in allergenic testing.
Approved
Cobimetinib
Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment of patients with unresectable or...
Approved
Investigational
Matched Categories: … UGT2B7 Substrates with a Narrow Therapeutic Index ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Aluminum hydroxide
Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects.
Approved
Investigational
Matched Description: … It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. …
Gluconic Acid
Commonly found in salts with sodium and calcium. Gluconic acid or gluconate is used to maintain the cation-anion balance on electrolyte solutions.
Approved
Investigational
Matched Mixtures name: … Plasma-Lyte A ... PLASMA-LYTE A INJECTION ... Plasma-lyte A Injection …
Drostanolone propionate
Approved
Illicit
Matched Iupac: … (1S,3aS,3bR,5aS,8R,9aS,9bS,11aS)-8,9a,11a-trimethyl-7-oxo-hexadecahydro-1H-cyclopenta[a]phenanthren-1 …
Chlorhexidine
Chlorhexidine is a broad-spectrum antimicrobial biguanide used as a topical antiseptic and in dental practice for the treatment of inflammatory dental conditions caused by microorganisms. It is one of the most common skin and mucous membrane antiseptic agents in use today. The molecule itself is a cationic bis-guanide consisting of...
Approved
Vet approved
Withdrawn
Matched Description: … Chlorhexidine is a broad-spectrum antimicrobial biguanide used as a topical antiseptic and in dental ... biguanide groups joined by a central hexamethylene chain. ... [A190417] The molecule itself is a cationic bis-guanide consisting of two 4-chlorophenyl rings and two …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Products: … Alsoft A Hand Disinfectant 0.2% w/v …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Products: … Alsoft A Hand Disinfectant 0.2% w/v …
Axitinib
Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. It is reported to exhibit potency that is 50-450 times higher than that of the first generation...
Approved
Investigational
Matched Description: … Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular …
Matched Categories: … UGT1A1 Substrates with a Narrow Therapeutic Index ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Matched Categories: … UGT1A1 Substrates with a Narrow Therapeutic Index ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Beremagene geperpavec
Beremagene geperpavec is a live, replication-defective herpes simplex virus type 1 (HSV-1)-based vector therapy. Developed by Krystal Biotech, it was first approved by the FDA on May 19, 2023, for the treatment of wounds associated with dystrophic epidermolysis bullosa (DEB). DEB is caused by mutations in the COL7A1 gene that...
Approved
Matched Description: … Beremagene geperpavec is a live, replication-defective herpes simplex virus type 1 (HSV-1)-based vector ... [L46916] DEB is caused by mutations in the _COL7A1_ gene that encodes collagen VII (COL7), a major component …
Hydrochlorothiazide
Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and angiotensin converting enzyme inhibitors[L8390,L8423] or angiotensin II receptor blockers.[L7426,L7459]
Hydrochlorothiazide was granted FDA...
Approved
Vet approved
Matched Mixtures name: … CO-IRVELL ... CO-DIOVAN ... CO-DIOVAN …
D-alpha-Tocopherol acetate
Alpha-tocopherol is the primary form of vitamin E that is preferentially used by the human body to meet appropriate dietary requirements. In particular, the RRR-alpha-tocopherol (or sometimes called the d-alpha-tocopherol stereoisomer) stereoisomer is considered the natural formation of alpha-tocopherol and generally exhibits the greatest bioavailability out of all of the...
Approved
Nutraceutical
Vet approved
Matched Description: … used as a food additive when needed [A32451]. ... subsequently most commonly indicated for dietary supplementation in individuals who may demonstrate a ... is naturally found in various foods, added to others, or used in commercially available products as a …
Matched Mixtures name: … Vitamin A C E W.niacinam.beta Car.and Min. …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Mixtures name: … Vitamin A C E W.niacinam.beta Car.and Min. …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Migalastat
Fabry disease is a rare, progressive genetic disorder characterized by a defective GLA gene that causes a deficiency in the enzyme alpha-Galactosidase A (alpha-Gal A). This enzyme is responsible for breaking down glycosphingolipid substrate that, when deficient in patients with Fabry disease, builds up in the blood vessels, the kidneys,...
Approved
Investigational
Matched Description: … a deficiency in the enzyme alpha-Galactosidase A (alpha-Gal A). ... Fabry disease is a rare, progressive genetic disorder characterized by a defective GLA gene that causes ... ,L4274,L4278] In these patients, migalastat works by stabilizing the body’s dysfunctional alpha-Gal A …
Matched Categories: … Alpha-Galactosidase A (alpha-Gal A) Pharmacological Chaperones …
Matched Categories: … Alpha-Galactosidase A (alpha-Gal A) Pharmacological Chaperones …
Fezolinetant
Vasomotor symptoms (VMS), more colloquially known as hot flashes or night sweats, are some of the most common symptoms in menopause. With a median duration of 7.4 years, vasomotor symptoms are also the most common reasons why women seek treatments for menopausal issues.[A259591,A259596] Although mostly considered a nuisance, vasomotor symptoms...
Approved
Investigational
Matched Iupac: … 5-[(8R)-7-(4-fluorobenzoyl)-8-methyl-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-3-yl]-3-methyl-1,2,4-thiadiazole …
Matched Description: … With a median duration of 7.4 years, vasomotor symptoms are also the most common reasons why women seek ... [A259591,A259596] Although mostly considered a nuisance, vasomotor symptoms can significantly affect ... quality of life, as women with 7 or more moderate to severe VMS daily have reported a decline in sleep …
Matched Description: … With a median duration of 7.4 years, vasomotor symptoms are also the most common reasons why women seek ... [A259591,A259596] Although mostly considered a nuisance, vasomotor symptoms can significantly affect ... quality of life, as women with 7 or more moderate to severe VMS daily have reported a decline in sleep …
Corticorelin ovine triflutate
Corticorelin, available commercially as corticorelin ovine triflutate (tradename Acthrel), is a synthetic form of the peptide human corticotropin-releasing hormone (hCRH), a potent stimulator of adrenocorticotropic hormone (ACTH) release from the anterior pituitary. Endogenous forms hCRH are involved in the stress response and its main function is stimulation of the pituitary...
Approved
Matched Description: … It provides a differential diagnosis for Cushing's disease (a pituitary source of ACTH excess) or of ... of a pituitary source from an ectopic source of excessive ACTH secretion. ... Corticorelin, available commercially as corticorelin ovine triflutate (tradename Acthrel), is a synthetic …
Tazobactam
Tazobactam is an antibiotic of the beta-lactamase inhibitor class that prevents the breakdown of other antibiotics by beta-lactamase enzyme producing organisms. It is combined with Piperacillin and Ceftolozane for the treatment of a variety of bacterial infections.
Piperacillin-tazobactam was initially approved by the FDA in 1994, and ceftolozane-tazobactam was approved...
Approved
Matched Description: … It is combined with [Piperacillin] and [Ceftolozane] for the treatment of a variety of bacterial infections …
Matched Mixtures name: … KABICTAM® POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCION INYECTABLE ... PIPERACILINA 4G + TAZOBACTAM 0.5G POLVO ESTERIL PARA RECONSTITUIR A SOLUCION INYECTABLE ... PIPERACILINA 4G + TAZOBACTAM 0.5G POLVO ESTERIL PARA RECONSTITUIR A SOLUCION INYECTABLE …
Matched Mixtures name: … KABICTAM® POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCION INYECTABLE ... PIPERACILINA 4G + TAZOBACTAM 0.5G POLVO ESTERIL PARA RECONSTITUIR A SOLUCION INYECTABLE ... PIPERACILINA 4G + TAZOBACTAM 0.5G POLVO ESTERIL PARA RECONSTITUIR A SOLUCION INYECTABLE …
Bexagliflozin
Bexagliflozin is a highly specific and potent sodium-glucose co-transporter 2 (SGLT2) inhibitor.[A256408,A256413,L44758] Similar to other SGLT2 inhibitors, bexagliflozin contains three basic moieties: glucose, two benzene rings and a methylene bridge. SGLT2 is responsible for 60% to 90% of renal glucose re-uptake, and unlike other isoforms such as SGLT1, SGLT2 is...
Approved
Investigational
Matched Description: … Bexagliflozin is a highly specific and potent sodium-glucose co-transporter 2 (SGLT2) inhibitor. ... other SGLT2 inhibitors, bexagliflozin contains three basic moieties: glucose, two benzene rings and a …
Procainamide
A derivative of procaine with less CNS action.
Approved
Matched Description: … A derivative of procaine with less CNS action. …
Matched Categories: … OCT2 Substrates with a Narrow Therapeutic Index ... MATE 1 Substrates with a Narrow Therapeutic Index ... MATE 2 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index ... Drugs that are Mainly Renally Excreted with a Narrow Therapeutic Index …
Matched Categories: … OCT2 Substrates with a Narrow Therapeutic Index ... MATE 1 Substrates with a Narrow Therapeutic Index ... MATE 2 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index ... Drugs that are Mainly Renally Excreted with a Narrow Therapeutic Index …
Propiolactone
Propiolactone is a lactone compound with a four-membered ring. It is a colorless liquid with a pungent slightly sweet odor. Propiolactone is a disinfectant used for the sterilization of blood plasma, vaccines, tissue grafts, surgical instruments, and enzymes. It has been used against bacteria, fungi, and virus. It is currently...
Approved
Withdrawn
Matched Description: … Propiolactone is a lactone compound with a four-membered ring. ... It is a colorless liquid with a pungent slightly sweet odor. ... Propiolactone is a disinfectant used for the sterilization of blood plasma, vaccines, tissue grafts, …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Levetiracetam
Levetiracetam is a drug within the pyrrolidine class that is used to treat various types of seizures stemming from epileptic disorders. It was first approved for use in the United States in 1999 and is structurally and mechanistically unrelated to other anti-epileptic drugs (AEDs).[L8606,L8600,L8615] Levetiracetam possesses a wide therapeutic index[L8615,A185918]...
Approved
Matched Description: … indexes and a propensity for involvement in drug interactions. ... Levetiracetam is a drug within the pyrrolidine class that is used to treat various types of seizures ... [L8606,L8600,L8615] Levetiracetam possesses a wide therapeutic index[L8615,A185918] and little-to-no …
Flavone
Approved
Experimental
Colchicine
Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as Colchicum autumnale, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events....
Approved
Matched Description: … Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as _Colchicum …
Erlotinib
Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is typically marketed under the trade name Tarceva. Erlotinib binds to the epidermal growth factor receptor (EGFR)...
Approved
Investigational
Matched Description: … Recent studies demonstrate that erlotinib is also a potent inhibitor of JAK2V617F, which is a mutant ... Erlotinib binds to the epidermal growth factor receptor (EGFR) tyrosine kinase in a reversible fashion ... form of tyrosine kinase JAK2 found in most patients with polycythemia vera (PV) and a substantial proportion …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Displaying drugs 251 - 275 of 11681 in total