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Displaying drugs 3076 - 3100 of 12063 in total

Clonidine

Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors. This activity is useful for the treatment of hypertension, severe pain, and ADHD.[L7237,L7240,L7243,L7246] Clonidine was granted FDA approval on 3 September 1974.
Approved
Matched Categories: … Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index …

Prasugrel

Prasugrel, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally and pharmacologically related to clopidogrel and ticlopidine. Similar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R-138727. R-138727 irreversibly binds to P2Y12 type ADP receptors on platelets thus preventing...
Approved
Matched Description: … Prasugrel was developed by Daiichi Sankyo Co. and is currently marketed in the United States and Canada ... Prasugrel, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally ... As a result, inhibition of ADP-mediated platelet activation and aggregation occurs. …

Dopamine

One of the catecholamine neurotransmitters in the brain. It is derived from tyrosine and is the precursor to norepinephrine and epinephrine. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (receptors, dopamine) mediate its action.
Approved
Matched Description: … A family of receptors (receptors, dopamine) mediate its action. ... Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating …
Matched Categories: … Monoamine Oxidase A Substrates ... Compounds used in a research, industrial, or household setting …

Idarubicin

An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity.
Approved
Matched Categories: … Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index …

Mafenide

Mafenide is a sulfonamide-type antimicrobial agent used to treat severe burns. It acts by reducing the bacterial population present in the burn tissue and promotes healing of deep burns. In 1998, mafenide acetate was approved under the FDA’s accelerated approval regulations. In November 2022, the use of mafenide acetate (powder...
Approved
Vet approved
Withdrawn
Matched Description: … Mafenide is a sulfonamide-type antimicrobial agent used to treat severe burns. …

Avibactam

Avibactam is a non-β-lactam β-lactamase inhibitor that is available in combination with ceftazidime (Avycaz). This combination was approved by the FDA on February 25, 2015 for the treatment of complicated intra-abdominal infections in combination with metronidazole, and the treatment of complicated urinary tract infections, including pyelonephritis caused by antibiotic resistant-pathogens,...
Approved
Matched Description: … Avibactam is a non-β-lactam β-lactamase inhibitor that is available in combination with ceftazidime ( …

Cynodon dactylon pollen

Cynodon dactylon pollen, also known as bermuda grass pollen, is a standardized grass pollen extracts used for the diagnosis and treatment of allergic disease to grass pollen. It can be cutaneously, intradermally and subcutaneously administered to initiate an immune response in case of an allergic reaction. Diagnostic allergenic extracts are...
Approved
Matched Description: … Cynodon dactylon pollen, also known as bermuda grass pollen, is a standardized grass pollen extracts …

Sodium cellulose phosphate

Sodium cellulose phosphate is used to treat hypercalcemia and hypercalciuria. It has been used to prevent kidney stones. This compound is an ion-exchange resin that can not be absorbed by the body. However, it can be used to restore normal intestinal calcium absorption.
Approved
Matched Categories: … Compounds used in a research, industrial, or household setting …

Octisalate

Also known as Ethylhexyl Salicylate. Octyl salicylate is an oil soluble chemical sunscreen agent that absorbs UVB radiation. It does not protect against UVA. Octyl salicylate is used to augment the UVB protection in a sunscreen. Salicylates are weak UVB absorbers and they are generally used in combination with other...
Approved
Investigational
Matched Description: … Octyl salicylate appears to have a good safety profile. ... Octyl salicylate is used to augment the UVB protection in a sunscreen. …
Matched Mixtures name: … Seaweed Bath Co. SPF-30 ... BANILA CO Prime Primer Sun ... Seaweed Bath Co SPF 40 Sport …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Homosalate

Homosalate is an organic compound that belongs to salicylates. It is an ester formed from salicylic acid and 3,3,5-trimethylcyclohexanol, a derivative of cyclohexanol. Salicylates prevent direct skin exposure to the sun’s harmful rays by absorbing ultraviolet (UV) light. Homosalate specifically absorbs short-wave UVB rays, which are associated with DNA damage...
Approved
Investigational
Matched Description: … It is a common ingredient in many commercially available sunscreens. ... It is an ester formed from salicylic acid and 3,3,5-trimethylcyclohexanol, a derivative of cyclohexanol …
Matched Mixtures name: … The Classeum Co., Ltd. ... BANILA CO Prime Primer Sun ... Hope In A Jar SPF 25 …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Turmeric

Turmeric is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
Approved
Experimental
Investigational
Matched Description: … Turmeric is a plant/plant extract used in some OTC (over-the-counter) products. …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Magnesium ascorbate

Approved
Nutraceutical
Matched Categories: … Compounds used in a research, industrial, or household setting …

Hypromellose

Hypromellose, or hydroxypropyl methylcellulose (HPMC) , is a semisynthetic, inert, and viscoelastic polymer that forms a colloid solution when dissolved in water. It acts as a thickening agent, coating polymer, bioadhesive, solubility enhancer in solid dispersions, and binder in the process of granulation and in modified release formulations . It...
Approved
Matched Description: … of a drug in a controlled fashion, effectively increasing the duration of release of a drug to prolong ... It is a commonly used as a delivery component in oral pharmaceutical products that provides the release ... polymer that forms a colloid solution when dissolved in water. …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Alectinib

Alectinib is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase. It is specifically used in the treatment of non-small cell lung cancer (NSCLC) expressing the ALK-EML4 (echinoderm microtubule-associated protein-like 4) fusion protein that causes proliferation of NSCLC cells. Inhibition of ALK...
Approved
Investigational
Matched Description: … Alectinib is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma …
Matched Categories: … Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …

Allopurinol

Gout is a disease that occurs by the deposition of monosodium urate crystals (MSU) in body tissues, especially around joints . This disease has been well-documented in historical medical records and appears in the biographies of several prominent, historically recognized individuals . Allopurinol is a xanthine oxidase enzyme inhibitor that...
Approved
Matched Description: … Gout is a disease that occurs by the deposition of monosodium urate crystals (MSU) in body tissues, especially ... Allopurinol is a xanthine oxidase enzyme inhibitor that is considered to be one of the most effective …

Streptococcus pneumoniae type 10a capsular polysaccharide antigen

Streptococcus pneumoniae type 10a capsular polysaccharide antigen is a vaccine that contains highly purified capsular polysaccharides from the invasive pneumococcal type 10a of Streptococcus pneumoniae. It is an active immunization for intramuscular or subcutaneous injection against pneumococcal disease such as pneumococcal pneumonia and pneumococcal bacteremia.
Approved
Investigational
Matched Description: … Streptococcus pneumoniae type 10a capsular polysaccharide antigen is a vaccine that contains highly purified …

Abacavir

Abacavir (ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS. Chemically, it is a synthetic carbocyclic nucleoside and is the enantiomer with 1S, 4R absolute configuration on the cyclopentene ring. In vivo, abacavir sulfate dissociates to its free base, abacavir.
Approved
Investigational
Matched Description: … Abacavir (ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV ... Chemically, it is a synthetic carbocyclic nucleoside and is the enantiomer with 1S, 4R absolute configuration …
Matched Mixtures name: … N/A …

Technetium Tc-99m sulfur colloid

Technetium 99m sulfur colloid is a radiopharmaceutical diagnostic agent used in the evaluation of various conditions including lymph node metastases in breast cancer, detection of shunt patency, imaging of reticuloendothelial cells for assessment of liver function, and studies of esophageal transit and gastroesophageal reflux. Following injection or oral administration, single...
Approved
Investigational
Matched Description: … Technetium 99m sulfur colloid is a radiopharmaceutical diagnostic agent used in the evaluation of various ... oral administration, single photon emission computer tomography (SPECT) imaging is performed using a ... is possible as Technetium-99m decays by isomeric transition to technetium-99 through the release of a …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Podophyllin

Podophyllin is a resin extracted from the roots of Podophyllum peltatum (American mandrake) and Podophyllum emodi, which contains numerous compounds, amongst which is podophyllin (as well as the drug podophyllotoxin). Podophyllin is the principal active component. Podophyllin arrests mitosis in metaphase.
Approved
Matched Description: … Podophyllin is a resin extracted from the roots of _Podophyllum peltatum_ (American mandrake) and _Podophyllum …
Matched Mixtures name: … PODOPHYLLIN PAINT, CO. …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Tiludronic acid

Tiludronate, or (4-chlorophenyl)thio-methylene-1,1-bisphosphonate, is a first generation bisphosphonate similar to etidronic acid and clodronic acid.[A1923,A203111] These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification. Tiludronic acid was first described in the literature in 1988 as a potential treatment for Paget's disease of bone....
Approved
Investigational
Vet approved
Matched Description: … Tiludronate, or (4-chlorophenyl)thio-methylene-1,1-bisphosphonate, is a first generation bisphosphonate ... [A1923] Tiludronic acid was first described in the literature in 1988 as a potential treatment for Paget's ... [A1923,A203111] These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification …
Matched Categories: … Phospholipases A, antagonists & inhibitors …

Fructose

Approved
Experimental
Matched Categories: … Compounds used in a research, industrial, or household setting …

Chloramphenicol succinate

Chloramphenicol succinate is an ester prodrug of chloramphenicol. Chloramphenicol is a bacteriostatic antibiotic. Use of chloramphenicol succinate and chloramphenicol has decreased due to the risk of potentially fatal blood dyscrasias. Chloramphenicol succinate was granted FDA approval on 20 February 1959.
Approved
Matched Description: … [A192987] Chloramphenicol is a bacteriostatic antibiotic. …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index …

Dimethyl fumarate

Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MMF up-regulates the Nuclear factor...
Approved
Investigational

Guanabenz

An alpha-2 selective adrenergic agonist used as an antihypertensive agent. [PubChem]
Approved
Investigational

Icatibant

Icatibant is a synthetic decapeptide with 5 nonproteinogenic amino acid antagonist targeting the B2 receptors with a similar affinity to bradykinin. It is resistant to bradykinin-cleaving enzyme degradation and has a potency of 2-3 times higher than earlier B2 receptors antagonists, thus representing a new class of medication.[A4017,A263041] It was...
Approved
Investigational
Matched Description: … >2 receptors with a similar affinity to bradykinin. ... earlier B2 receptors antagonists, thus representing a new class of medication. ... Icatibant is a synthetic decapeptide with 5 nonproteinogenic amino acid antagonist targeting the B
Displaying drugs 3076 - 3100 of 12063 in total