Displaying drugs 3251 - 3275 of 11512 in total
Nicotine
Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
Approved
Matched Categories: … Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates …
Dequalinium
Dequalinium is an antibacterial agent with multi-targeted actions. It also possesses antifungal, antiparasitic, antiviral, anticancer, and neuroprotective properties. It is a quaternary ammonium compound, as it consists of an amphipathic cation with two aminoquinaldinium rings at both ends of a long hydrophobic hydrocarbon chain. Due to its flexible structure, dequalinium...
Approved
Investigational
Matched Description: … two aminoquinaldinium rings at both ends of a long hydrophobic hydrocarbon chain. ... [A249255] It is a quaternary ammonium compound,[L42190] as it consists of an amphipathic cation with …
Catumaxomab
Catumaxumab is a trifunctional monoclonal antibody developed for use in cancer treatment. It has affinity for T-cells, accessory immune cells, and cancer cells. Catumaxumab was initially authorized for market by the European Medicines Agency in April 2009 for the treatment of malignant ascites . Its market authorization was withdrawn in...
Approved
Investigational
Withdrawn
Matched Description: … Catumaxumab is a trifunctional monoclonal antibody developed for use in cancer treatment. …
Gefapixant
It has been estimated that 5-10% of adults globally suffer from chronic cough, which is defined as a cough lasting longer than eight weeks. A subset of these patients remain symptomatic despite thorough investigation and treatment, termed refractory chronic cough (RCC) if they have a cough that does not respond...
Approved
Investigational
Matched Description: … It has been estimated that 5-10% of adults globally suffer from chronic cough, which is defined as a ... [L48601] A subset of these patients remain symptomatic despite thorough investigation and treatment, ... termed refractory chronic cough (RCC) if they have a cough that does not respond to conventional treatment …
L-Glutamine
A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from glutamic acid and ammonia. It is the principal carrier of nitrogen in the body and is an important energy source for many cells. An oral formulation of L-glutamine was approved...
Approved
Investigational
Nutraceutical
Matched Description: … A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes …
Taurolidine
Taurolidine is an antimicrobial used for the prevention of catheter-related infections. It is a derivative of the amino acid taurine.
It was first synthesized in the 1970s and was originally used as a prophylactic against intraperitoneal bacterial infections in patients with peritonitis. In November 2023, a catheter lock solution of...
Approved
Investigational
Matched Description: … It is a derivative of the amino acid [taurine]. ... It was first synthesized in the 1970s and was originally used as a prophylactic against intraperitoneal ... and Antifungal Drugs (LPAD pathway) for the prevention of catheter-related bloodstream infections in a …
Magnesium acetate
Approved
Cidofovir
Cidofovir is an injectable antiviral medication employed in the treatment of cytomegalovirus (CMV) retinitis in patients diagnosed with AIDS. It suppresses CMV replication through selective inhibition of viral DNA synthesis.[FDA label] It was manufactured by Gilead and initially approved by the FDA in 1996, but has since been discontinued.
Approved
Teplizumab
Teplizumab (teplizumab-mzwv) is a humanized IgG1 kappa CD3-directed monoclonal antibody used to delay the onset of type 1 diabetes (T1D).[A241480,A241045,A241475,L44091] T1D is an autoimmune condition in which T cell-mediated destruction of pancreatic β cells leads to loss of insulin production, impaired glycemic control, and reliance on exogenous insulin. Anti-CD3 therapy...
Approved
Investigational
Matched Description: … Teplizumab (teplizumab-mzwv) is a humanized IgG1 kappa CD3-directed monoclonal antibody used to delay …
Tezepelumab
Asthma is a heterogeneous chronic obstructive respiratory disease with both "type 2" (T2) and T2-low endotypes characterized by reduced airflow, chronic inflammation, and airway remodelling.[A243764, A243769] Thymic stromal lymphopoietin (TSLP), an innate pleiotropic IL-2-family cytokine, has emerged as a key upstream regulator of chronic inflammation across asthma endotypes. Blocking the...
Approved
Investigational
Matched Description: … Asthma is a heterogeneous chronic obstructive respiratory disease with both "type 2" (T2) and T2-low ... A243769] Thymic stromal lymphopoietin (TSLP), an innate pleiotropic IL-2-family cytokine, has emerged as a ... [A243764, A243769, A243774]
Tezepelumab is a human monoclonal IgG2λ antibody directed against TSLP …
Desloratadine
Desloratadine is a second generation, tricyclic antihistamine that which has a selective and peripheral H1-antagonist action. It is the active descarboethoxy metabolite of loratidine (a second generation histamine). Desloratidine has a long-lasting effect and does not cause drowsiness because it does not readily enter the central nervous system.
Approved
Investigational
Matched Description: … Desloratadine is a second generation, tricyclic antihistamine that which has a selective and peripheral ... It is the active descarboethoxy metabolite of loratidine (a second generation histamine). ... Desloratidine has a long-lasting effect and does not cause drowsiness because it does not readily enter …
Lumateperone
Schizophrenia is a complex mental illness and impacts approximately 1% of the population. Although there are several antipsychotics including aripiprazole, paliperidone and clozapine available for clinical use, they are generally accompanied by significant metabolic and/or neurological adverse effects. Lumateperone is a newly approved 2nd generation antipsychotic currently indicated for the...
Approved
Investigational
Matched Description: … Schizophrenia is a complex mental illness and impacts approximately 1% of the population. ... [A189093]
Lumateperone is a newly approved 2nd generation antipsychotic currently indicated for the ... [A189093] Both characteristics lend to a more favourable adverse effect profile and ultimately safer …
Leflunomide
Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999.
Approved
Investigational
Matched Description: … Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic …
Levomefolic acid
Levomefolic acid (INN) is the metabolite of folic acid (Vitamin B9) and it is a predominant active form of folate found in foods and in the blood circulation, accounting for 98% of folates in human plasma . It is transported across the membranes including the blood-brain barrier into various tissues...
Approved
Investigational
Matched Description: … Levomefolate is approved as a food additive and is designated a GRAS (generally regarded as safe) compound ... stability required for use as a supplement [A19276]. ... Levomefolic acid (INN) is the metabolite of folic acid (Vitamin B9) and it is a predominant active form …
Lanolin alcohols
Lanolin alcohols are a complex combination of organic alcohols obtained by the hydrolysis of lanolin. It is administered as an ointment base with topical insulin and has shown to be antagonistic to wound healing. It is commonly used in allergenic testing.
Approved
Experimental
Matched Description: … Lanolin alcohols are a complex combination of organic alcohols obtained by the hydrolysis of lanolin. …
Darbepoetin alfa
Human erythropoietin with 2 aa substitutions to enhance glycosylation (5 N-linked chains), 165 residues (MW=37 kD). Produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology.
Approved
Investigational
Foreskin fibroblast (neonatal)
Foreskin fibroblast-like stromal cells (FDSCs) are progenitors isolated from human tissue that can differentiate into various cell types .
Also known as Dermagraft, this device is a cryopreserved human fibroblast-derived dermal substitute. Composed of fibroblasts, extracellular matrix, and a bioabsorbable scaffold, it effectively supports wound healing .
Dermagraft has only...
Approved
Matched Description: … Also known as Dermagraft, this device is a cryopreserved human fibroblast-derived dermal substitute. ... Composed of fibroblasts, extracellular matrix, and a bioabsorbable scaffold, it effectively supports ... Dermagraft has been combined with [DB10772] to create a drug beneficial to patients with open burn wounds …
Foreskin keratinocyte (neonatal)
Skin, the largest organ of the human body, plays the main role in protecting the body from mechanical damage. It is composed of epidermal, dermal and hypodermal layers. The barrier function of the skin owed to its avascular epidermal layer, which is made mainly of keratinocytes. The keratinocytes form a...
Approved
Matched Description: … Foreskin keratinocytes are a form of skin cells that are cultured as a skin cell replacement for wounds ... Keratinocytes are derived from neonatal foreskins and used to create a drug called _Apligraf_, a mixture ... To construct a "living" alternative, a dermal substitute based on collagen I gel was created with mesenchymal …
Necitumumab
Necitumumab is an intravenously administered recombinant monoclonal IgG1 antibody used in the treatment of non-small cell lung cancer (NSCLC) as an EGFR antagonist. It functions by binding to epidermal growth factor receptor (EGFR) and prevents binding of its ligands, a process that is involved in cell proliferation, metastasis, angiogenesis, and...
Approved
Investigational
Matched Description: … functions by binding to epidermal growth factor receptor (EGFR) and prevents binding of its ligands, a ... Necitumumab is approved for use in combination with cisplatin and gemcitabine as a first-line treatment …
Epcoritamab
Epcoritamab is an IgG1-bispecific antibody that simultaneously binds to CD3 on T-cells and CD20 on B-cells.[A259736,A258488,A259761,L46516] Epcoritamab promotes the activation and expansion of T-cells and, by being able to bind to both CD20 and CD3, it leads to the T-cell–mediated killing of CD20+ malignant B cells.[A259761,L46516] Diffuse large B-cell lymphoma...
Approved
Investigational
Matched Description: … for the treatment of a variety of hematologic malignancies. ... approval for this indication may be contingent upon verification and description of clinical benefit in a ... [L46516] It is administered subcutaneously and is currently being evaluated as a monotherapy and in combination …
Gatifloxacin
Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatifloxacin is available as...
Approved
Investigational
Withdrawn
Matched Description: … Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Diosmin
Chronic venous insufficiency is a common condition the western population. Compression and pharmacotherapy are frequently used to manage chronic venous insufficiency, improving circulation and symptoms of venous disease. Diosmin is a bioflavonoid isolated from various plants or synthesized from hesperidin. It is used for the improvement of capillary fragility or...
Approved
Investigational
Matched Description: … Diosmin is widely available over-the-counter and demonstrates a favourable a favorable safety profile ... Chronic venous insufficiency is a common condition the western population. ... [A232885]
Diosmin is a bioflavonoid isolated from various plants or synthesized from [hesperidin]. …
Voxilaprevir
Voxilaprevir is a Direct-Acting Antiviral (DAA) medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common...
Approved
Investigational
Matched Description: … Voxilaprevir is a Direct-Acting Antiviral (DAA) medication used as part of combination therapy to treat ... HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 ... Voxilaprevir has been available since July 2017 in a fixed dose combination product with [sofosbuvir] …
Timolol
Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes. It is also used in tablet form as a drug to treat hypertension. Timolol was first approved by the FDA in 1978. This drug is marketed by several manufacturers...
Approved
Matched Description: … [L6724] It is also used in tablet form as a drug to treat hypertension. ... Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular …
Morpholinylmercaptobenzothiazole
Approved
Experimental
Displaying drugs 3251 - 3275 of 11512 in total