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Displaying drugs 701 - 725 of 13886 in total

Bilastine

Bilastine is a novel new-generation antihistamine that is highly selective for the H1 histamine receptor, has a rapid onset and prolonged duration of action.
Approved
Investigational
Matched Description: … Bilastine is a novel new-generation antihistamine that is highly selective for the H1 histamine receptor ... , has a rapid onset and prolonged duration of action. …
Matched Categories: … Antihistamines for Systemic Use …

Corticotropin

Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis.
Approved
Investigational
Vet approved
Matched Description: … It is an important player in the hypothalamic-pituitary-adrenal axis. ... Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by …
Matched Categories: … Corticosteroids for Systemic Use …

Ertugliflozin

Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018.
Approved
Investigational
Matched Description: … Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes ... [A31581] Ertugliflozin was first approved by the FDA in December 2017. ... [A261951, L1132] It was also approved by the European Commission in March 2018.[L48621] …
Matched Categories: … Drugs Used in Diabetes …

Rilonacept

Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold auto-inflammatory syndrome...
Approved
Investigational
Matched Description: … Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein ... Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as ... syndromes, including familial cold auto-inflammatory syndrome (FCAS) and Muckle-Wells Syndrome (MWS), in …
Matched Categories: … Agents reducing cytokine levels …

Encainide

All drug products containing encainide hydrochloride. Encainide hydrochloride, formerly marketed as Enkaid capsules, was associated with increased death rates in patients who had asymptomatic heart rhythm abnormalities after a recent heart attack. The manufacturer of Enkaid capsules voluntarily withdrew the product from the US market on December 16, 1991.
Approved
Investigational
Withdrawn
Matched Description: … All drug products containing encainide hydrochloride. ... patients who had asymptomatic heart rhythm abnormalities after a recent heart attack. ... Encainide hydrochloride, formerly marketed as Enkaid capsules, was associated with increased death rates in …

Lorazepam

Lorazepam is a short-acting and rapidly cleared benzodiazepine used commonly as a sedative and anxiolytic. It was developed by DJ Richards, presented and marketed initially by Wyeth Pharmaceuticals in the USA in 1977. The first historic FDA label approval is reported in 1985 by the company Mutual Pharm.
Approved
Matched Description: … Lorazepam is a short-acting and rapidly cleared benzodiazepine used commonly as a sedative and anxiolytic ... the USA in 1977. ... The first historic FDA label approval is reported in 1985 by the company Mutual Pharm.[L5095] …

Isoprenaline

Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that this isopropyl analog of epinephrine dilated the bronchi, as well as raising...
Approved
Investigational
Matched Description: … a stronger action than [adrenaline]. ... attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, ... [A15638,L33160] Isoprenaline research in the 1940s found that this isopropyl analog of epinephrine …
Matched Categories: … Compounds used in a research, industrial, or household setting ... Adrenergics for Systemic Use ... Drugs for Obstructive Airway Diseases ... isoprenaline and other drugs for obstructive airway diseases …

Axitinib

Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. It is reported to exhibit potency that is 50-450 times higher than that of the first generation...
Approved
Investigational
Matched Description: … Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular ... [A179398] It is most commonly marketed under the name Inlyta® and is available in oral formulations. …
Matched Categories: … UGT1A1 Substrates with a Narrow Therapeutic Index ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …

Tyloxapol

Tyloxapol is a non-ionic detergent often used as a surfactant.
Approved
Investigational
Matched Description: … Tyloxapol is a non-ionic detergent often used as a surfactant. …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Molybdenum

Molybdenum is a chemical element with symbol Mo and atomic number 42. As it is not a naturally occuring free metal on Earth, molybdenum is found only in various oxidation states in minerals. Molybdenum is commonly used in metallurgy and other chemical applications however it has essential biological roles in...
Approved
Matched Description: … As it is not a naturally occuring free metal on Earth, molybdenum is found only in various oxidation ... It is an essential trace dietary element and acts as a critical cofactor in several molybdenum-dependent ... When complexed with Technetium Tc 99m, molybdenum is used as a radiopharmaceutical agent in diagonistic …
Matched Mixtures name: … Multivitamins and Minerals for Men ... Multivitamins and Minerals for Women ... Extra Once A Day …

Ethanolamine oleate

Ethanolamine oleate is a mild sclerosing agent. It is composed of ethanolamine, a basic substance, which when combined with oleic acid forms a clear, straw to pale yellow colored, deliquescent oleate.
Approved
Matched Description: … It is composed of ethanolamine, a basic substance, which when combined with oleic acid forms a clear, ... Ethanolamine oleate is a mild sclerosing agent. …
Matched Categories: … Compounds used in a research, industrial, or household setting ... Sclerosing Agents for Local Injection …

Ipecac

Ipecac is obtained from the plant Cephaelis ipecacuanha and contains a number of emetic alkaloids including emetine and cephaeline. Ipecac was approved by Health Canada as an OTC but all those products are now discontinued. The FDA does not have currently any approved product containing ipecac, however, ipecac as an...
Approved
Withdrawn
Matched Description: … packages of 1 fluid ounce (30 ml) for the emergency use to cause vomiting in poisoning. ... [L2753] Ipecac was approved by Health Canada as an OTC but all those products are now discontinued. ... Ipecac is obtained from the plant _Cephaelis ipecacuanha_ and contains a number of emetic alkaloids including …

Lorpiprazole

Lorpiprazole is a serotonin antagonist and reuptake inhibitor used for the treatment of major depressive disorder. It is a piperazinyl-triazole derivative.
Approved
Matched Description: … Lorpiprazole is a serotonin antagonist and reuptake inhibitor used for the treatment of major depressive ... [A31634] It is a piperazinyl-triazole derivative.[T83] …

Cenegermin

Cenegermin is a human beta-nerve growth factor (beta-ngf)-(1-118)- peptide (non-covalent dimer) produced in escherichia coli. It received European Union Approval in July 2017 for the treatment of moderate to severe neurotrophic keratitis. Cenegermin received approval from the US FDA a year later in August of 2018. Neurotrophic keratitis is a...
Approved
Investigational
Matched Description: … It received European Union Approval in July 2017 for the treatment of moderate to severe neurotrophic ... Cenegermin received approval from the US FDA a year later in August of 2018. ... significant improvement in the safety or effectiveness of the treatment, diagnosis or prevention of a …

Ramelteon

Ramelteon is the first in a new class of sleep agents that selectively binds to the melatonin receptors in the suprachiasmatic nucleus (SCN). It is used for insomnia, particularly delayed sleep onset. Ramelteon has not been shown to produce dependence and has shown no potential for abuse.
Approved
Investigational
Matched Description: … Ramelteon is the first in a new class of sleep agents that selectively binds to the melatonin receptors ... in the suprachiasmatic nucleus (SCN). ... It is used for insomnia, particularly delayed sleep onset. …

Agalsidase beta

Agalsidase beta is a recombinant human α-galactosidase A similar to agalsidase alfa. While patients generally do not experience a clinically significant difference in outcomes between the two drugs, some patients may experience greater benefit with agalsidase beta.[A220228,A220233] Use of agalsidase beta has decreased in Europe, in favor of agalsidase alfa,...
Approved
Investigational
Matched Description: … a contamination event in 2009. ... While patients generally do not experience a clinically significant difference in outcomes between the ... Agalsidase beta is a recombinant human α-galactosidase A similar to [agalsidase alfa]. …

Bisoxatin

Bisoxatin is a stimulant laxative which increases peristalsis and inhibits absorbtion of water and ions in the intestine . It is marketed in Belgium under the tradename Wylaxine and used for the treatment of constipation and for preparation of the colon for surgical procedures.
Approved
Matched Description: … It is marketed in Belgium under the tradename Wylaxine and used for the treatment of constipation and ... in the intestine [L926]. ... Bisoxatin is a stimulant laxative which increases peristalsis and inhibits absorbtion of water and ions …
Matched Categories: … Drugs for Constipation …

Tafamidis

Tafamidis and tafamidis meglumine (FX-1006A) are benzoxazole derivatives developed by FoldRX. Tafamidis is structurally similar to diflusinal. Tafamidis was granted an EMA market authorisation on 16 November 2011 and FDA approval on 3 May 2019.
Approved
Investigational

Clemastine

An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness.
Approved
Investigational
Matched Description: … An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic …
Matched Categories: … Antihistamines for Systemic Use ... Antihistamines for Topical Use …

Levamlodipine

Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of amlodipine, an antihypertensive medication. Levamlodipine belongs to the dihydropyridine group of calcium channel blockers. This medication was first marketed in Russia and India before being granted FDA approval. The names S-amlodipine and levamlodipine may be used interchangeably as both...
Approved
Investigational
Matched Description: … [L10833] This medication was first marketed in Russia and India before being granted FDA approval. ... Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of [amlodipine], ... [L10833] As a racemic mixture, amlodipine contains (R) and (S)-amlodipine isomers, but only (S)-amlodipine …
Matched Categories: … Antihypertensive Agents Indicated for Hypertension …

Trichloroethylene

Trichloroethylene is a halocarbon commonly used as an industrial solvent, not to be confused with the similar 1,1,1-trichloroethane, also known as chlorothene. It has been sold under a variety of trade names including Trimar and Trilene and used as a volatile anesthetic and as an inhaled obstetrical analgesic. Environmental exposure,...
Approved
Matched Description: … major concern for human health and has been the subject of numerous incidents and lawsuits. ... It has been sold under a variety of trade names including Trimar and Trilene and used as a volatile anesthetic ... Trichloroethylene is a halocarbon commonly used as an industrial solvent, not to be confused with the …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Brigatinib

Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the EML4-ALK fusion gene, which is a...
Approved
Investigational
Matched Description: … pivotal player in the transformation of susceptible lung parenchyma. ... Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK ... selectivity against 9 different Crizotinib-resistant mutants of the EML4-ALK fusion gene, which is a …
Matched Categories: … Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …

Cyclacillin

A cyclohexylamido analog of penicillanic acid.
Approved
Matched Description: … A cyclohexylamido analog of penicillanic acid. …
Matched Categories: … Antibacterials for Systemic Use ... Antiinfectives for Systemic Use …

Enalaprilat

Enalaprilat is the active metabolite of the orally available pro-drug, enalapril. Used in the treatment of hypertension, enalapril is an ACE inhibitor that prevents Angiotensin Converting Enzyme (ACE) from transforming angiotensin I into angiotensin II. As angiotensin II is responsible for vasoconstriction and sodium reabsorption in the proximal tubule of...
Approved
Matched Description: … As angiotensin II is responsible for vasoconstriction and sodium reabsorption in the proximal tubule ... overcome the limitations of the first ACE inhibitor, captopril, which had numerous side effects and left a ... Enalaprilat is poorly orally available and is therefore only available as an intravenous injection for …
Matched Categories: … Antihypertensive Agents Indicated for Hypertension …

Levocabastine

Levocabastine is a selective second-generation H1-receptor antagonist used for allergic conjunctivitis. Levocabastine was discovered at Janssen Pharmaceutica in 1979.
Approved
Investigational
Matched Description: … Levocabastine is a selective second-generation H1-receptor antagonist used for allergic conjunctivitis ... Levocabastine was discovered at Janssen Pharmaceutica in 1979. …
Displaying drugs 701 - 725 of 13886 in total