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Displaying drugs 226 - 250 of 8033 in total

Polysorbate 80

Polysorbate, a substance formulated by the reaction of sorbitan fatty acid ester (a nonionic surfactant) with ethylene oxide, is used in many foreign countries, including the U.S. and the EU, where it acts as an emulsifier, a solubilizer in many foods, including bread, cake mix, salad dressing, shortening oil and...
Approved
Matched Description: … Polysorbate, a substance formulated by the reaction of sorbitan fatty acid ester (a nonionic surfactant ... substance that would not normally dissolve in a particular solution is able to dissolve with the use of ... [L1852] A solubilizing agent acts as a surfactant and increases the solubility of one agent in another …

Amprenavir

Amprenavir is a protease inhibitor used to treat HIV infection.
Approved
Investigational
Matched Categories: … Drugs for Treatment of Tuberculosis …

Asenapine

Developed by Schering-Plough after its merger with Organon International, asenapine is a sublingually administered, atypical antipsychotic for treatment of schizophrenia and acute mania associated with bipolar disorder. Asenapine also belongs to the dibenzo-oxepino pyrrole class. It is also for severe post-traumatic stress disorder nightmares in soldiers as an off-label use....
Approved
Matched Description: … Organon International, asenapine is a sublingually administered, atypical antipsychotic for treatment of …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Celecoxib

Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of causing gastrointestinal bleeding compared to other NSAIDS. It is used to manage symptoms of various types of arthritis pain and in familial adenomatous polyposis (FAP) to reduce precancerous polyps in...
Approved
Investigational
Matched Description: … [A181544] It is used to manage symptoms of various types of arthritis pain and in familial adenomatous ... ) inhibitor, is a nonsteroidal anti-inflammatory drug (NSAID) which is known for its decreased risk of ... evaluated as potential cancer chemopreventive and therapeutic drugs in clinical trials for a variety of …
Matched Categories: … combinations of sulfonamides …

Ciprofloxacin

Ciprofloxacin is a second generation fluoroquinolone that has spawned many derivative antibiotics. It is formulated for oral, intravenous, intratympanic, ophthalmic, and otic administration for a number of bacterial infections.[L6469,L6472,L6475,L6478,L6481,L6484,L6487,L6490,L6493] The first ciprofloxacin containing product was FDA approved on 22 October 1987.
Approved
Investigational
Matched Description: … is formulated for oral, intravenous, intratympanic, ophthalmic, and otic administration for a number of …
Matched Categories: … Metabolic Side Effects of Drugs and Substances …

Risperidone

Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. Paliperidone, another commonly used SGA, is the primary active metabolite of risperidone (i.e. 9-hydroxyrisperidone). Schizophrenia and...
Approved
Investigational
Matched Description: … Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of ... [L12885] It is one of the most widely used SGAs. ... Risperidone is thought to reduce this overactivity through inhibition of dopaminergic D2 receptors and …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Buprenorphine

Buprenorphine is a weak partial mu-opioid receptor agonist and a weak kappa-opioid receptor antagonist used for the treatment of severe pain.[A186283,A186292] It is also commonly used as an alternative to methadone for the treatment of severe opioid addiction. Buprenorphine is commercially available as the brand name product Suboxone which is...
Approved
Illicit
Investigational
Vet approved
Matched Description: … agent for the treatment of conditions requiring high doses of strong opioids. ... Provision of OAT is often combined with education about harm reduction including use of clean needles ... The intention of substitution of illicit opioids with the long-acting opioids used in OAT is to prevent …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Clarithromycin

Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarithromycin may be bacteriostatic or bactericidal depending on the organism and drug...
Approved
Matched Categories: … Metabolic Side Effects of Drugs and Substances …

Quetiapine

Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable option for some patients with high...
Approved
Matched Description: … [L8546] Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Methotrimeprazine

A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604)
Approved
Investigational
Matched Description: … effects resembling those of chlorpromazine. ... A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine ... It has the histamine-antagonist properties of the antihistamines together with central nervous system …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Selumetinib

Activation of the Raf-MEK-ERK signalling pathway is known to be implemented in several types of malignancies; thus, mitogen-activated protein kinase kinase (MEK) inhibitors such as selumetinib are important tools that can target the problematic overactivity of this pathway. Results from clinical trials investigating earlier developed MEK inhibitors were underwhelming. However,...
Approved
Investigational
Matched Description: … Activation of the Raf-MEK-ERK signalling pathway is known to be implemented in several types of malignancies ... various types of tumours in Phase II trials. ... NF-1 is considered rare, with an estimated incidence of 1/3000 individuals. …

Anthralin

Anthralin (1,8‐dihydroxy‐9anthrone, dithranol) is an older anti-psoriatic agent that was first synthesized as a derivative of chrysarobin, obtained from the araroba tree in Brazil over 100 years ago. Adverse effects of anthralin include irritation and discoloration of the skin . This specific property of the molecule inspired workers to study...
Approved
Matched Description: … Adverse effects of anthralin include irritation and discoloration of the skin [A27277]. ... This specific property of the molecule inspired workers to study details of its pharmacology. ... It is a main active ingredient in topical skin formulations for the treatment of psoriasis. …

Ramipril

Ramipril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to ramiprilat in the liver and, to a lesser extent, kidneys. Ramiprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII)....
Approved
Matched Description: … Ramiprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin ... reduce the rate of death, myocardial infarction and stroke in individuals at high risk of cardiovascular ... Ramipril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor class of medications …

Prucalopride

Prucalopride is a dihydrobenzofurancarboxamide derivative from the benzofurane family that selectively stimulates 5-HT4 receptors and thus, it presents enterokinetic properties. The high selectivity of prucalopride allowed further development as it prevented the cardiac adverse reactions observed due to non-target effects of precedent therapies. Prucalopride was developed by Shire Development LLC...
Approved
Matched Description: … adverse reactions observed due to non-target effects of precedent therapies. ... [A37348] The high selectivity of prucalopride allowed further development as it prevented the cardiac …

Vadadustat

One of the most common symptoms of advanced renal disease is anemia, caused primarily by the inability of the kidney to respond to anemic conditions with a corresponding increase in erythropoietin (EPO) production. The treatment of anemia associated with chronic kidney disease (CKD) has traditionally involved the administration of exogenous...
Approved
Investigational
Matched Description: … One of the most common symptoms of advanced renal disease is anemia, caused primarily by the inability ... These transcription factors serve a multitude of roles, including the stimulation of erythropoiesis. ... of CKD, and increases in overall mortality. …

Fexofenadine

Fexofenadine is an over-the-counter second-generation antihistamine used in the treatment of various allergic symptoms. It is selective for the H1 receptor, carries little-to-no activity at off-targets, and does not cross the blood-brain barrier - this is in contrast to previous first-generation antihistamines, such as diphenhydramine, which readily bind to off-targets...
Approved
Investigational
Matched Description: … Fexofenadine is an over-the-counter second-generation antihistamine used in the treatment of various ... [A1452] Fexofenadine is the major active metabolite of [terfenadine][A1495] and is administered as a …

Isavuconazole

Isavuconazole is an triazole antifungal with broad spectrum of activity and good safety profile . It is approved by the FDA and EMA for the treatment of invasive aspergillosis and mucormycosis. It works by inhibiting fungal cell membrane synthesis. Invasive fungal infections pose significant clinical challenges for patients, especially those...
Approved
Investigational
Matched Description: … It is approved by the FDA and EMA for the treatment of invasive aspergillosis and mucormycosis. ... Isavuconazole is an triazole antifungal with broad spectrum of activity and good safety profile [A32026 ... In vitro, most of the _Candida_ species, most _Aspergillus_ species, Mucorales, _Cryptococcus_ spp., …

Flecainide

Flecainide is a Class I anti-arrhythmic agent like encainide and propafenone. Flecainide’s development began in 1966 and was first synthesized in 1972 as an attempt to generate new anesthetics. It is used to prevent supraventricular and ventricular arrhythmias, as well as paroxysmal atrial fibrillation and flutter.[L8878,L5056] Flecainide was granted FDA...
Approved
Withdrawn

Epirubicin

An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA.
Approved
Matched Description: … An anthracycline which is the 4'-epi-isomer of doxorubicin. ... The compound exerts its antitumor effects by interference with the synthesis and function of DNA. …

Potassium nitrate

Potassium nitrate is an inorganic salt with a chemical formula of KNO3. It is a natural source of nitrate and has been used as a constituent for several different purposes, including food preservatives, fertilizers, tree stump removal, rocket propellants, and fireworks. Potassium nitrate is a common active ingredient in toothpaste,...
Approved
Matched Description: … Potassium nitrate is an inorganic salt with a chemical formula of KNO3. ... It is a natural source of nitrate and has been used as a constituent for several different purposes, ... It provides increasing protection against painful sensitivity of the teeth to cold, heat, acids, sweets …

Clascoterone

Clascoterone (cortexolone 17α-propionate, CB-03-01) is a novel antagonist of androgen receptors. It binds to androgen receptors with high affinity. By competing with androgens for binding to androgen receptors, clascoterone works by blocking the androgen receptor signalling cascades that promote acne pathogenesis, such as sebaceous gland proliferation, excess sebum production, and...
Approved
Investigational
Matched Description: … Clascoterone (cortexolone 17α-propionate, CB-03-01) is a novel antagonist of androgen receptors. ... [A218846] In August 2020, FDA approved clascoterone for the first-in-class topical treatment of acne …

Aurothioglucose

Aurothioglucose, also known as gold thioglucose, was formerly used to treat rheumatoid arthritis. Contemporary research on the effect of gold salts treatment began in 1935, primarily to reduce inflammation and to slow disease progression in patients with rheumatoid arthritis . The use of gold compounds has decreased since the 1980s...
Approved
Withdrawn
Matched Description: … , and slow onset of action. ... Contemporary research on the effect of gold salts treatment began in 1935, primarily to reduce inflammation ... The use of gold compounds has decreased since the 1980s owing to numerous side effects, limited efficacy …

Mometasone furoate

Mometasone furoate is a corticosteroid drug that can be used for the treatment of asthma, rhinitis, and certain skin conditions[FDA Label][F4292,F4295]. It has a glucocorticoid receptor binding affinity 22 times stronger than dexamethasone and higher than many other corticosteroids as well . Mometasone furoate is formulated as a dry powder...
Approved
Investigational
Vet approved
Matched Description: … Mometasone furoate is a corticosteroid drug that can be used for the treatment of asthma, rhinitis, and …

Piracetam

Piracetam is a nootropic drug in the racetams group, with chemical name 2-oxo-1-pyrrolidine acetamide. It shares the same 2-oxo-pyrrolidone base structure with pyroglutamic acid and is a cyclic derivative of the neurotransmitter γ-aminobutyric acid (GABA). However its mechanism of action differ from that of endogenous GABA. Piracetam has neuroprotective and...
Approved
Investigational
Matched Description: … However its mechanism of action differ from that of endogenous GABA. ... shares the same 2-oxo-pyrrolidone base structure with pyroglutamic acid and is a cyclic derivative of …

Bromazepam

One of the benzodiazepines that is used in the treatment of anxiety disorders. It is a Schedule IV drug in the U.S. and Canada and under the Convention on Psychotropic Substances. It is a intermediate-acting benzodiazepine.
Approved
Illicit
Investigational
Matched Description: … One of the benzodiazepines that is used in the treatment of anxiety disorders. …
Displaying drugs 226 - 250 of 8033 in total