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Displaying drugs 351 - 375 of 1353 in total
Ivabradine
Ivabradine is a novel heart rate lowering medicine for the symptomatic management of stable angina pectoralis and symptomatic chronic heart failure. Ivabradine, brand name Corlanor, was approved by the FDA in April 2015 for the treatment of chronic heart failure in patients with an ejection fraction of ≤35%, in sinus...
Approved
Matched Description: … and symptomatic chronic heart failure. ... Ivabradine is a novel heart rate lowering medicine for the symptomatic management of stable angina pectoralis ... Ivabradine, brand name Corlanor, was approved by the FDA in April 2015 for the treatment of chronic heart …
Tolvaptan
Tolvaptan is used to treat low blood sodium levels (hyponatremia) associated with various conditions like congestive heart failure, cirrhosis, and syndrome of inappropriate antidiuretic hormones (SIADH). FDA approved on May 19, 2009.
Approved
Matched Description: … to treat low blood sodium levels (hyponatremia) associated with various conditions like congestive heart …
Atorvastatin
Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competitively inhibit the enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) Reductase,...
Approved
Matched Description: … By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol ... of this class of drugs is largely attributed to the rise in cardiovascular diseases (CVD) (such as heart ... years) statin use leads to a 20%-22% relative reduction in the number of major cardiovascular events (heart …
Bisoprolol
Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-adrenergic receptor...
Approved
Dobutamine
A beta-1 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery.
Approved
Matched Description: … It is proposed as a cardiotonic after myocardial infarction or open heart surgery. …
Digoxin
Digoxin is one of the oldest cardiovascular medications used today. It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. This drug originates from the foxglove plant, also...
Approved
Matched Description: … [A178225] It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. …
Sulfur hexafluoride
Sulfur hexafluoride is an ultrasound contrast agent indicated for use
•in echocardiography to opacify the left ventricular chamber and to improve the delineation of the left ventricular endocardial border in adult patients with suboptimal echocardiograms
•in ultrasonography of the liver for characterization of focal liver lesions in adult and pediatric...
Approved
Matched Description: … for characterization of focal liver lesions in adult and pediatric patients ... ventricular endocardial border in adult patients with suboptimal echocardiograms
•in ultrasonography of the liver …
Avatrombopag
Avatrombopag (Doptelet), is an orally administered, small molecule thrombopoietin receptor (c-Mpl) agonist that increases platelet number without increasing platelet activation,[A33097,L2824] thereby decreasing the need for blood transfusions. Patients with thrombocytopenia and chronic liver disease often require platelet transfusions before surgical procedures to decrease the risk of bleeding. Thrombocytopenia is a...
Approved
Investigational
Matched Description: … occurring as a result of liver disease or a consequence of interferon-based antiviral therapy. ... [L2824] Patients with thrombocytopenia and chronic liver disease often require platelet transfusions ... [A33095] Thrombocytopenia is a common complication in patients suffering from chronic liver disease, …
Finerenone
Finerenone, or BAY 94-8862, is a mineralocorticoid receptor antagonist indicated to reduce the risk of sustained decline in glomerular filtration rate, end stage kidney disease, cardiovascular death, heart attacks, and hospitalization due to heart failure in adults with chronic kidney disease associated with type II diabetes mellitus.[A236519,L34739] Patients with kidney...
Approved
Investigational
Matched Description: … of sustained decline in glomerular filtration rate, end stage kidney disease, cardiovascular death, heart ... attacks, and hospitalization due to heart failure in adults with chronic kidney disease associated with …
Rosiglitazone
Rosiglitazone is an anti-diabetic drug in the thiazolidinedione class of drugs. It is marketed by the pharmaceutical company GlaxoSmithKline as a stand-alone drug (Avandia) and in combination with metformin (Avandamet) or with glimepiride (Avandaryl). Like other thiazolidinediones, the mechanism of action of rosiglitazone is by activation of the intracellular receptor...
Approved
Investigational
Ramipril
Ramipril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to ramiprilat in the liver and, to a lesser extent, kidneys. Ramiprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII)....
Approved
Matched Description: … It is metabolized to ramiprilat in the liver and, to a lesser extent, kidneys. ... Ramipril may be used in the treatment of hypertension, congestive heart failure, nephropathy, and to …
Gadoxetic acid
Gadoxetic acid (gadoxetate) is a paramagnetic gadolinium-containing ionic linear contrast agent in which its salt form, gadoxetate disodium, is used for intravenous injection. Ethoxybenzyl diethylenetriaminepentaacetic acid is the moiety that chelates with a gadolinium ion and forms a stable complex with it to make up the drug. Gadoxetate is a...
Approved
Matched Description: … the liver parenchyma-liver tumours contrast. ... tumor cells lack OATPs, liver tumors show a lack of contrast of enhancement and therefore heightening ... A263146] Since gadoxetate uptake is mediated by organic anion-transporting polypeptides (OATPs) and liver …
Ademetionine
Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
Approved
Investigational
Nutraceutical
Matched Description: … It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. …
Threonine
An essential amino acid occurring naturally in the L-form, which is the active form. It is found in eggs, milk, gelatin, and other proteins.
Approved
Nutraceutical
Doconexent
A mixture of fish oil and primrose oil, doconexent is used as a high-docosahexaenoic acid (DHA) supplement. DHA is a 22 carbon chain with 6 cis double bonds with anti-inflammatory effects. It can be biosythesized from alpha-linolenic acid or commercially manufactured from microalgae. It is an omega-3 fatty acid and...
Approved
Investigational
Matched Mixtures name: … GNC Cod Liver Oil Plus …
Nadolol
Nadolol is a nonselective beta adrenal receptor blocker that is used to lower blood pressure.[L7922,L7925] Nonselective beta adrenal receptor blockers may no longer be first line in the treatment of hypertension as newer generations of beta adrenal receptor blockers have higher selectivity and offer better rates of adverse effects. Nadolol...
Approved
Cholic Acid
A major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. [PubChem]
Cholic acid, formulated as Cholbam capsules, is approved by the United States Food and Drug Administration as a treatment for children and adults with bile acid...
Approved
Matched Description: … A major primary bile acid produced in the liver and usually conjugated with glycine or taurine. …
Matched Categories: … Bile and Liver Therapy …
Matched Categories: … Bile and Liver Therapy …
Enoximone
Enoximone is a selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity that does not cause changes in myocardial oxygen consumption. It is used in patients with congestive heart failure. Trials were halted in the U.S., but the drug is used in various countries.
Approved
Investigational
Matched Description: … It is used in patients with congestive heart failure. …
Flotufolastat F-18
Flotufolastat F-18 (18F-rhPSMA-7.3) is an 18F-labeled ligand that targets the prostate-specific membrane antigen (PSMA).[A259846,L46731] In patients with recurrent prostate cancer that require localized treatment, the use of 18F-labeled ligands for positron emission tomography (PET) offers accurate diagnostic imaging. Unlike 68Ga-labeled PSMA-targeting ligands, 18F-labeled compounds targeting this protein have a longer...
Approved
Investigational
Matched Description: … other diastereoisomers of this compound, flotufolastat F-18 has a faster clearance from blood pool, liver …
Chenodeoxycholic acid
Chenodeoxycholic acid (or Chenodiol) is an epimer of ursodeoxycholic acid (DB01586). Chenodeoxycholic acid is a bile acid naturally found in the body. It works by dissolving the cholesterol that makes gallstones and inhibiting production of cholesterol in the liver and absorption in the intestines, which helps to decrease the formation...
Approved
Matched Description: … It can also reduce the amount of other bile acids that can be harmful to liver cells when levels are ... by dissolving the cholesterol that makes gallstones and inhibiting production of cholesterol in the liver …
Matched Categories: … Bile and Liver Therapy …
Matched Categories: … Bile and Liver Therapy …
Vitamin E
In 1922, vitamin E was demonstrated to be an essential nutrient . Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active . Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage . The antioxidant effects...
Approved
Nutraceutical
Vet approved
Matched Mixtures name: … GNC Cod Liver Oil Plus …
Nitroglycerin
Nitroglycerin, also known as glyceryl trinitrate, is an organic nitrate and a vasodilating agent that was first discovered in 1847. Originally used to dynamite, its antianginal effects were identified in the late 1860s after it produced headaches in factory workers while workers with angina pectoris or heart failure experienced relief...
Approved
Investigational
Matched Description: … the late 1860s after it produced headaches in factory workers while workers with angina pectoris or heart ... due to coronary artery disease,[L7102,L7141,L38369,L42320] peri-operative hypertension, congestive heart …
Olmesartan
Olmesartan belongs to the angiotensin II receptor blocker (ARB) family of drugs, which also includes telmisartan, candesartan, losartan, valsartan, and irbesartan. ARBs selectively bind to angiotensin receptor 1 (AT1) and prevent the protein angiotensin II from binding and exerting its hypertensive effects, which include vasoconstriction, stimulation and synthesis of aldosterone...
Approved
Investigational
Matched Description: … In particular, heart failure is associated with chronic activation of RAAS, leading to inappropriate ... ARBs have been shown to have a protective effect on the heart by improving cardiac function, reducing ... RAAS, which is a contributing factor to the pathogenesis and progression of cardiovascular disease, heart …
Phenol
Phenol is an antiseptic and disinfectant. It is active against a wide range of micro-organisms including some fungi and viruses, but is only slowly effective against spores. Phenol has been used to disinfect skin and to relieve itching. Phenol is also used as an oral analgesic or anesthetic in products...
Approved
Experimental
Matched Products: … Liver supplement …
Digitoxin
A cardiac glycoside sometimes used in place of digoxin. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665)
Approved
Investigational
Displaying drugs 351 - 375 of 1353 in total