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Displaying drugs 501 - 525 of 14979 in total

Estriol

A hydroxylated metabolite of estradiol or estrone that has a hydroxyl group at C3-beta, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During pregnancy, large amount of estriol is produced by the placenta. Isomers with inversion of the hydroxyl group or groups are called epiestriol. Though estriol is...
Approved
Investigational
Vet approved
Matched Description: … It has also been approved and marketed throughout Europe and Asia for approximately 40 years for the ... A hydroxylated metabolite of estradiol or estrone that has a hydroxyl group at C3-beta, 16-alpha, and …
Matched Categories: … Genito Urinary System and Sex Hormones ... Natural and Semisynthetic Estrogens, Plain ... Sex Hormones and Modulators of the Genital System ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Hydrocortisone probutate

Approved
Vet approved
Matched Categories: … Hydrocortisone and derivatives ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Mitotane

Mitotane is an adrenolytic isomer of the insecticide dichlorodiphenyldichloroethane (DDD) - itself a metabolite of dichlorodiphenyltrichloroethane (DDT) - that inhibits cells of the adrenal cortex and their production of hormones. It has been in use since 1959 for the treatment of inoperable adrenocortical carcinoma and is used off-label for the...
Approved
Matched Description: … It has been in use since 1959 for the treatment of inoperable adrenocortical carcinoma[A263010] and is ... itself a metabolite of dichlorodiphenyltrichloroethane (DDT) - that inhibits cells of the adrenal cortex and …
Matched Categories: … Antineoplastic and Immunomodulating Agents …

Bleomycin

A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin.
Approved
Investigational
Matched Description: … It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. ... of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Cytotoxic Antibiotics and Related Substances …

Rimexolone

Rimexolone is a 1% eye drop solution is a glucocorticoid steroid. It is used to treat inflammation in the eye. It is marketed as Vexol.
Approved
Matched Categories: … Sex Hormones and Insulins ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Oxitriptan

5-Hydroxytryptophan (5-HTP), also known as oxitriptan (INN), is a naturally occurring amino acid and metabolic intermediate in the synthesis of serotonin and melatonin. 5-HTP is sold over-the-counter in the United Kingdom, United States and Canada as a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, and...
Approved
Investigational
Nutraceutical
Matched Iupac: … (2S)-2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid …
Matched Description: … 5-Hydroxytryptophan (5-HTP), also known as oxitriptan (INN), is a naturally occurring amino acid and ... suppressant, and sleep aid, and is also marketed in many European countries for the indication of major ... metabolic intermediate in the synthesis of serotonin and melatonin. 5-HTP is sold over-the-counter in …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Trolamine

Trolamine, which is also referred to as triethanolamine (TEA), is a tertiary amine and a triol. It is a bifunctional compound that exhibits both properties of alcohols and amines. Trolamine contains small amounts of diethanolamine and ethanolamine and may also act as an antioxidant against the auto-oxidation of animal and...
Approved
Matched Description: … and hair conditioning products. ... Trolamine contains small amounts of diethanolamine and ethanolamine and may also act as an antioxidant ... It is commonly used as a pH adjuster and surfactant in industrial and cosmetic products such as skin …
Matched Categories: … Preparations for Treatment of Wounds and Ulcers …

Zuranolone

Zuranolone is a neuroactive steroid that acts as a positive allosteric modulator of the GABAA receptors. Unlike other more common GABAA positive allosteric modulators on the market like benzodiazepines, zuranolone can modulate both synaptic and extrasynaptic GABAA conductance due to binding to a non-benzodiazepine site on the receptor.[A260776,A260786] Zuranolone was...
Approved
Experimental
Matched Description: … positive allosteric modulators on the market like benzodiazepines, zuranolone can modulate both synaptic and ... [A260791] Zuranolone was approved by the FDA on August 4th, 2023, and it is currently the only approved …
Matched Categories: … Neuroactive Steroid Gamma-Aminobutyric Acid A Receptor Positive Modulator …

Lipegfilgrastim

Lipegfilgrastim, previously known as XM22, is a pegylated, recombinant granulocyte colony-stimulating factor (G-CSF) that was synthetized using a highly site-specific glycoPEGylation technology . It is used as an alternate to DB00019 for prophylactic use in cancer patients receiving chemotherapy and at risk for developing chemotherapy-induced neutropenia. Since July 2013, lipegfilgrastim...
Approved
Investigational
Matched Description: … mass of lipegfilgrastim comprises 18,798 Da for [DB00099], 203 Da for GalNAc, 338 Da for glycylsialic acid ... polyethylene glycol (PEG) molecule via a carbohydrate linker consisting of glycine, N-acetylneuraminic acid ... Neutropenia and febrile neutropenia (FN) are frequent and potentially fatal complications that occur …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Intercellular Signaling Peptides and Proteins …

Dolutegravir

Dolutegravir is an HIV-1 integrase inhibitor that blocks the strand transfer step of the integration of the viral genome into the host cell (INSTI). The effect of this drug has no homology in human host cells, which gives it excellent tolerability and minimal toxicity. Dolutegravir was developed by ViiV Healthcare...
Approved
Matched Description: … [A31342] Dolutegravir was developed by ViiV Healthcare and FDA-approved on August 12, 2013. ... The effect of this drug has no homology in human host cells, which gives it excellent tolerability and …
Matched Salts name: … Dolutegravir sodium …
Matched Categories: … lamivudine and dolutegravir ... dolutegravir and rilpivirine ... lamivudine, abacavir and dolutegravir ... lamivudine, tenofovir disoproxil and dolutegravir …

Elagolix

Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the first and only...
Approved
Investigational
Matched Iupac: … trifluoromethyl)phenyl]methyl}-4-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-1-yl]-1-phenylethyl]amino}butanoic acid …
Matched Description: … , Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. ... Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis ... and only oral gonadotropin-releasing hormone (GnRH) antagonist specifically developed for women with …
Matched Salts name: … Elagolix sodium …
Matched Categories: … Pituitary and Hypothalamic Hormones and Analogues ... Sex Hormones and Insulins ... Antigonadotropins and Similar Agents ... elagolix, estradiol and norethisterone …

Volanesorsen

Volanesorsen is an antisense oligonucleotide that binds to apoC-III mRNA to prevent its translation. It is indicated to treat familial chylomicronemia, a genetic condition that prevents breakdown of triglycerides and chylomicrons. This drug is not commonly prescribed as it is used as an adjunct to diet in patients at high...
Approved
Investigational
Matched Description: … indicated to treat familial chylomicronemia, a genetic condition that prevents breakdown of triglycerides and …
Matched Salts name: … Volanesorsen sodium …
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides …

Tipranavir

Tipranavir is a sulfonamide-containing dyhydropyrone and a nonpeptidic protease inhibitor that targets the HIV protease. Tipranavir and ritonavir are coadministered to treat HIV.
Approved
Investigational
Matched Description: … Tipranavir and ritonavir are coadministered to treat HIV. ... Tipranavir is a sulfonamide-containing dyhydropyrone and a nonpeptidic protease inhibitor that targets …

Risperidone

Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. Paliperidone, another commonly used SGA, is the primary active metabolite of risperidone (i.e. 9-hydroxyrisperidone). Schizophrenia and...
Approved
Investigational
Matched Description: … D2 and serotonergic 5-HT2A activity, resulting in overactivity of central mesolimbic pathways and mesocortical ... mental health conditions including schizophrenia and bipolar disorder. ... Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and …

Metoprolol

Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succinate derivative. To this date,...
Approved
Investigational
Matched Description: … widely prescribed in the Netherlands, New Zealand, and the US. ... Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives ... [T274] To this date, it is one of the preferred beta-blockers in general clinical guidelines and it is …
Matched Mixtures name: … Metoprolol Tartrate and Hydrochlorothiazide ... Metoprolol Tartrate and Hydrochlorothiazide ... Metoprolol Tartrate and Hydrochlorothiazide …
Matched Categories: … metoprolol and acetylsalicylic acid ... metoprolol and thiazides ... metoprolol and felodipine ... metoprolol and ivabradine ... metoprolol and amlodipine …

Dornase alfa

Dornase alfa is a biosynthetic form of human deoxyribunuclease I (DNase I) enzyme. It is produced in genetically modified Chinese hamster ovary (CHO) cells using recombinant DNA technology. The 260-amino acid sequence of dornase alfa is identical to the endogenous human enzyme. Dornase alfa cleaves extracellular DNA to 5´-phosphodinucleotide and...
Approved
Matched Description: … The 260-amino acid sequence of dornase alfa is identical to the endogenous human enzyme. ... Enzymatic breakdown of this extracellular DNA appears to reduce sputum viscosity and viscoelasticity. ... Dornase alfa cleaves extracellular DNA to 5´-phosphodinucleotide and 5´-phosphooligonucleotide end products …
Matched Categories: … Enzymes and Coenzymes ... Cough and Cold Preparations ... Amino Acids, Peptides, and Proteins …

Dalteparin

Dalteparin, a low molecular weight heparin (LMWH) prepared by nitrous acid degradation of unfractionated heparin of porcine intestinal mucosa origin, is an anticoagulant. It is composed of strongly acidic sulphated polysaccharide chains with an average molecular weight of 5000 and about 90% of the material within the range of 2000-9000....
Approved
Matched Description: … Dalteparin, a low molecular weight heparin (LMWH) prepared by nitrous acid degradation of unfractionated ... composed of strongly acidic sulphated polysaccharide chains with an average molecular weight of 5000 and ... LMWHs have a more predictable response, a greater bioavailability, and a longer anti-Xa half life than …
Matched Salts name: … Dalteparin sodium …
Matched Categories: … Heparin and similars ... Blood and Blood Forming Organs …

Tenofovir alafenamide

Tenofovir alafenamide is a novel tenofovir prodrug developed in order to improve renal safety when compared to the counterpart tenofovir disoproxil. Both of these prodrugs were first created to cover the polar phosphonic acid group on tenofovir by using a novel oxycarbonyloxymethyl linkers to improve the oral bioavailability and intestinal...
Approved
Matched Description: … [A178060] Both of these prodrugs were first created to cover the polar phosphonic acid group on tenofovir ... [L4388,L9010] Tenofovir alafenamide was developed by Gilead Sciences Inc and granted FDA approval ... alafenamide is indicated to treat chronic hepatitis B,[L6241] treat HIV-1,[L4388,L6277,L6280,L6283] and …
Matched Categories: … Tenofovir and prodrugs ... Amino Acids, Peptides, and Proteins ... emtricitabine and tenofovir alafenamide ... emtricitabine, tenofovir alafenamide and rilpivirine ... emtricitabine, tenofovir alafenamide and bictegravir …

Sinapultide

Sinapultide (also known as KL4 peptide) is a synthetic protein used to mimic human lung surfactant protein B. This protein has a weight of 2469.40. Sinapultide is a 21-residue peptide made up of lysine (K) and leucine (L) residues with the sequence KLLLLKLLLLKLLLLKLLLLK (KL4), in aqueous dispersion with the phospholipids...
Approved
Matched Iupac: … hexanamido]-4-methylpentanamido]-4-methylpentanamido]-4-methylpentanamido]-4-methylpentanamido]hexanoic acid …
Matched Description: … palmitic acid, to create the drug [lucinactant]. ... Surfactant replacement therapy has been commonly used to prevent and treat RDS in these newborns and ... [L2502] Sinapultide is a 21-residue peptide made up of lysine (K) and leucine (L) residues with the …
Matched Categories: … Amino Acids, Peptides, and Proteins …

Fluocinolone acetonide

Fluocinolone acetonide, with the formula 6-alpha, 9-alpha-difluoro-16-alpha, 17 alpha-acetonide, is a corticosteroid that presents a high lipophilicity. It has been used extensively in dermatological preparations and it has also been investigated thoroughly for its use in implantable corticosteroid devices. This type of device containing fluocinolone acetonide was developed by Taro...
Approved
Investigational
Vet approved
Matched Description: … [T357] It has been used extensively in dermatological preparations and it has also been investigated ... [T358] This type of device containing fluocinolone acetonide was developed by Taro Pharmaceuticals and …
Matched Mixtures name: … Ciprofloxacin and Fluocinolone Acetonide ... Ciprofloxacin and Fluocinolone Acetonide …
Matched Categories: … fluocinolone acetonide and antiseptics ... fluocinolone acetonide and antibiotics ... fluocinolone acetonide and antiinfectives ... fluocinolone acetonide and antiinfectives ... Hormones, Hormone Substitutes, and Hormone Antagonists …

Cycloserine

Antibiotic substance produced by Streptomyces garyphalus.
Approved
Matched Categories: … Amino Acids, Peptides, and Proteins …

Rosiglitazone

Rosiglitazone is an anti-diabetic drug in the thiazolidinedione class of drugs. It is marketed by the pharmaceutical company GlaxoSmithKline as a stand-alone drug (Avandia) and in combination with metformin (Avandamet) or with glimepiride (Avandaryl). Like other thiazolidinediones, the mechanism of action of rosiglitazone is by activation of the intracellular receptor...
Approved
Investigational
Matched Description: … Rosiglitazone is a selective ligand of PPARγ, and has no PPARα-binding action. ... It is marketed by the pharmaceutical company GlaxoSmithKline as a stand-alone drug (Avandia) and in combination ... resistance, it appears to have an anti-inflammatory effect: nuclear factor kappa-B (NFκB) levels fall and …
Matched Categories: … Alimentary Tract and Metabolism ... metformin and rosiglitazone ... glimepiride and rosiglitazone …

Pregnenolone

A 21-carbon steroid, derived from cholesterol and found in steroid hormone-producing tissues. Pregnenolone is the precursor to gonadal steroid hormones and the adrenal corticosteroids.
Approved
Experimental
Matched Description: … A 21-carbon steroid, derived from cholesterol and found in steroid hormone-producing tissues. ... Pregnenolone is the precursor to gonadal steroid hormones and the adrenal corticosteroids. …
Matched Categories: … Hormones, Hormone Substitutes, and Hormone Antagonists …

Linaclotide

Linaclotide is a synthetic 14-amino acid cyclic peptide and first-in-class guanylate cyclase-C (G-CC) agonist.[A260271, L47211] Linaclotide is structurally related to human guanylin and uroguanylin, paracrine peptide hormones that are endogenous activators of GC-C. It is also a homolog of a heat-stable enterotoxin derived from Escherichia coli, the first natural ligand...
Approved
Matched Iupac: … dodecaazatetracyclo[22.22.4.2^{16,33}.0^{7,11}]dopentacontan-38-yl]formamido}-3-(4-hydroxyphenyl)propanoic acid …
Matched Description: … Linaclotide is a synthetic 14-amino acid cyclic peptide [A260271] and first-in-class guanylate cyclase-C ... [A260271] It gained EMA and Health Canada approval on November 26, 2012 [L47216] and December 3, 2013 ... [A260271, L47211] Linaclotide is structurally related to human guanylin and uroguanylin, paracrine peptide …
Matched Categories: … Alimentary Tract and Metabolism ... Amino Acids, Peptides, and Proteins …

Glycopyrronium

Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers. They are both quaternary ammonium compounds and long acting muscarinic antagonists. It is one of the most commonly prescribed anticholinergic medications.[A233535,A233540] Early research into glycopyrronium use was for its indication as an adjunct therapy in the...
Approved
Investigational
Vet approved
Matched Description: … [L33110] They are both quaternary ammonium compounds and long acting muscarinic antagonists. ... found that glycopyrronium could also be used for reducing sweat gland,[L4755] oral,[L33140] airway, and ... L33105] Glycopyrronium is commonly prescribed as a first line treatment for a wide variety indications and …
Matched Categories: … Alimentary Tract and Metabolism ... formoterol and glycopyrronium bromide ... indacaterol and glycopyrronium bromide ... glycopyrronium bromide and psycholeptics ... formoterol, glycopyrronium bromide and budesonide …
Displaying drugs 501 - 525 of 14979 in total