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Displaying drugs 551 - 575 of 14428 in total
Clozapine
Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical". . This low affinity to dopamine receptors results in fewer extrapyramidal side effects,...
Approved
Matched Description: … side effects, notably gastrointestinal hypomotility and orthostatic hypotension. ... [A185747] However, its promiscuity toward the muscarinic and adrenergic receptors can result in other ... Despite its effectiveness in treating both positive and negative symptoms of schizophrenia, clozapine …
Matched Salts name: … Clozapine hydrochloride …
Matched Categories: … Diazepines, Oxazepines, Thiazepines and Oxepines …
Matched Salts name: … Clozapine hydrochloride …
Matched Categories: … Diazepines, Oxazepines, Thiazepines and Oxepines …
Riluzole
A glutamate antagonist (receptors, glutamate) used as an anticonvulsant (anticonvulsants) and to prolong the survival of patients with amyotrophic lateral sclerosis. Riluzole is marketed as Rilutek by Sanofi.
Approved
Investigational
Matched Description: … A glutamate antagonist (receptors, glutamate) used as an anticonvulsant (anticonvulsants) and to prolong …
Matched Salts name: … Riluzole Hydrochloride …
Matched Salts name: … Riluzole Hydrochloride …
Levocabastine
Levocabastine is a selective second-generation H1-receptor antagonist used for allergic conjunctivitis. Levocabastine was discovered at Janssen Pharmaceutica in 1979.
Approved
Investigational
Matched Salts name: … Levocabastine hydrochloride …
Matched Categories: … Decongestants and Antiallergics …
Matched Categories: … Decongestants and Antiallergics …
Rotigotine
Rotigotine (Neupro) is a non-ergoline dopamine agonist indicated for the treatment of Parkinson's disease (PD) and restless legs syndrome (RLS) in Europe and the United States. It is formulated as a once-daily transdermal patch which provides a slow and constant supply of the drug over the course of 24 hours....
Approved
Matched Description: … restless legs syndrome (RLS) in Europe and the United States. ... It was approved by the European Medicines Agency in 2006 and by the FDA in 2007. ... (Neupro) is a non-ergoline dopamine agonist indicated for the treatment of Parkinson's disease (PD) and …
Matched Salts name: … Rotigotine hydrochloride …
Matched Salts name: … Rotigotine hydrochloride …
Finafloxacin
Finafloxacin is a fluoroquinolone antibiotic indicated in the treatment of acute otitis externa (swimmer's ear) caused by the bacteria Pseudomonas aeruginosa and Staphylococcus aureus. Finafloxacin is marketed by Novartis under the brand Xtoro™, and was approved by the FDA in December 2014.
Approved
Investigational
Matched Description: … the treatment of acute otitis externa (swimmer's ear) caused by the bacteria Pseudomonas aeruginosa and ... Finafloxacin is marketed by Novartis under the brand Xtoro™, and was approved by the FDA in December …
Matched Salts name: … finafloxacin hydrochloride …
Matched Salts name: … finafloxacin hydrochloride …
Defibrotide
Defibrotide is the sodium salt of a mixture of single-stranded oligodeoxyribonucleotides derived from porcine mucosal DNA. It has been shown to have antithrombotic, anti-inflammatory and anti-ischemic properties (but without associated significant systemic anticoagulant effects). It is marketed under the brand names Dasovas (FM), Noravid, and Prociclide in a variety of...
Approved
Investigational
Matched Description: … It has been shown to have antithrombotic, anti-inflammatory and anti-ischemic properties (but without ... It is marketed under the brand names Dasovas (FM), Noravid, and Prociclide in a variety of countries. …
Matched Categories: … Blood and Blood Forming Organs ... Nucleic Acids, Nucleotides, and Nucleosides …
Matched Categories: … Blood and Blood Forming Organs ... Nucleic Acids, Nucleotides, and Nucleosides …
Plasminogen
Plasminogen is a pro-enzyme (i.e. a zymogen) which is cleaved to form plasmin - also known as fibrinolysin - as part of the fibrinolytic pathway that breaks down fibrin blood clots. This pathway is activated when a clot is no longer needed or to prevent a clot from extending beyond...
Approved
Matched Description: … [L34615] It is the first and only FDA-approved treatment for this condition, which causes wood-like lesions …
Matched Categories: … Enzymes and Coenzymes ... Amino Acids, Peptides, and Proteins …
Matched Categories: … Enzymes and Coenzymes ... Amino Acids, Peptides, and Proteins …
Terconazole
Terconazole is an anti-fungal drug that is mainly used to treat vaginal yeast infections (or vaginal candidiasis). It is classified as a triazole ketal derivative. Terconazole was initially approved by the FDA in 1987.[FDA label] This drug is available in cream and suppository forms and both have demonstrated high levels...
Approved
Matched Description: … [FDA label] This drug is available in cream and suppository forms and both have demonstrated high levels ... of safety, efficacy, and tolerability in clinical trials. …
Matched Categories: … Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …
Matched Categories: … Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …
Sodium acetate
Sodium Acetate is chemically designated CH3COONa, a hygroscopic powder very soluble in water. Sodium acetate could be used as additives in food, industry, concrete manufacture, heating pads and in buffer solutions. Medically, sodium acetate is important component as an electrolyte replenisher when given intravenously. It is mainly indicated to correct...
Approved
Investigational
Matched Description: … It can be used also in metabolic acidosis and for urine alkalinization. ... Sodium acetate could be used as additives in food, industry, concrete manufacture, heating pads and in …
Matched Mixtures name: … Plasma-Lyte 148 and dextrose ... Normosol-R and Dextrose ... Plasma-Lyte M and Dextrose …
Matched Categories: … Blood and Blood Forming Organs ... Blood Substitutes and Perfusion Solutions …
Matched Mixtures name: … Plasma-Lyte 148 and dextrose ... Normosol-R and Dextrose ... Plasma-Lyte M and Dextrose …
Matched Categories: … Blood and Blood Forming Organs ... Blood Substitutes and Perfusion Solutions …
Cefmetazole
A semisynthetic cephamycin antibiotic with a broad spectrum of activity against both gram-positive and gram-negative microorganisms. It has a high rate of efficacy in many types of infection and to date no severe side effects have been noted.
Approved
Investigational
Matched Description: … A semisynthetic cephamycin antibiotic with a broad spectrum of activity against both gram-positive and ... It has a high rate of efficacy in many types of infection and to date no severe side effects have been …
Argatroban
Argatroban is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary intervention. Argatroban is a non-heparin anticoagulant shown to both normalize platelet count in patients...
Approved
Investigational
Matched Description: … Parental anticoagulants must be stopped and a baseline activated partial thromboplastin time must be ... Argatroban is a non-heparin anticoagulant shown to both normalize platelet count in patients with HIT and ... bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and …
Matched Categories: … Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …
Matched Categories: … Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …
Meprobamate
A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Meprobamate has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (which may be exacerbated)....
Approved
Illicit
Matched Description: … A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses ... It is used in the treatment of anxiety disorders, and also for the short-term management of insomnia …
Matched Categories: … Hypnotics and Sedatives …
Matched Categories: … Hypnotics and Sedatives …
Acetohexamide
A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market.
Approved
Investigational
Withdrawn
Matched Categories: … Alimentary Tract and Metabolism ... Genito Urinary System and Sex Hormones ... Gynecological Antiinfectives and Antiseptics …
Acetohydroxamic acid
Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure to urea. In the urine, it acts as an antagonist of the bacterial enzyme urease. Acetohydroxamic Acid has no direct antimicrobial action and does not acidify urine directly. It is used, in addition to antibiotics...
Approved
Matched Description: … Acetohydroxamic Acid has no direct antimicrobial action and does not acidify urine directly. ... Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure …
Matched Categories: … Genito Urinary System and Sex Hormones …
Matched Categories: … Genito Urinary System and Sex Hormones …
Carbenicillin
Broad-spectrum semisynthetic penicillin derivative used parenterally. It is susceptible to gastric juice and penicillinase and may damage platelet function.
Approved
Investigational
Matched Description: … It is susceptible to gastric juice and penicillinase and may damage platelet function. …
Nafcillin
A semi-synthetic antibiotic related to penicillin, Naficillin is a narrow-spectrum beta-lactam antibiotic drug. It is a beta-lactamase-resistant penicillin that is indicated for the treatment of Staphylococcal infections caused by strains that are resistant to other penicillins, except those caused by MRSA. It may be used as a first-line therapy in...
Approved
Investigational
Ibandronate
Ibandronate, or BM 21.0955, is a third generation, nitrogen containing bisphosphonate similar to zoledronic acid, minodronic acid, and risedronic acid.[A203111,A203138] It is used to prevent and treat postmenopausal osteoporosis.[L13805,L13808] Ibandronate was first described in the literature in 1993 as a treatment for bone loss in dogs. Ibandronate was granted FDA...
Approved
Investigational
Matched Description: … [A203111,A203138] It is used to prevent and treat postmenopausal osteoporosis. ... third generation, nitrogen containing bisphosphonate similar to [zoledronic acid], [minodronic acid], and …
Matched Categories: … ibandronic acid and colecalciferol ... Drugs Affecting Bone Structure and Mineralization …
Matched Categories: … ibandronic acid and colecalciferol ... Drugs Affecting Bone Structure and Mineralization …
Zalcitabine
A dideoxynucleoside compound in which the 3'-hydroxyl group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of 5' to 3' phosphodiester linkages, which are needed for the elongation of DNA chains, thus resulting in the termination of viral DNA growth. The compound is...
Approved
Investigational
Matched Categories: … Nucleic Acids, Nucleotides, and Nucleosides ... Nucleoside and Nucleotide Reverse Transcriptase Inhibitors …
Dactinomycin
A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin...
Approved
Investigational
Matched Description: … It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Cytotoxic Antibiotics and Related Substances …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... Cytotoxic Antibiotics and Related Substances …
Ambenonium
Ambenonium is a cholinesterase inhibitor. It is used in the management of myasthenia gravis.
Approved
Meticillin
One of the penicillins which is resistant to penicillinase but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection.
Approved
Investigational
Taurine
Taurine, whose chemical name is 2-aminoethanesulfonic acid, is one of the most abundant amino acids in several organs. It plays important role in essential biological processes. This conditional amino acid can be either be manufactured by the body or obtained in the diet mainly by the consumption of fish and...
Approved
Nutraceutical
Matched Description: … can be either be manufactured by the body or obtained in the diet mainly by the consumption of fish and ... [L1058] The supplements containing taurine were FDA approved by 1984 and they are hypertonic injections …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Displaying drugs 551 - 575 of 14428 in total